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- Hoffmann, Thomas J, et al.
(författare)
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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction
- 2023
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (p≤5e-8) variants, 184 of which were novel. Most demonstrated evidence of replication in an independent cohort (n=95,768). Meta-analyzing discovery and replication (n=392,522) identified 447 variants, of which a further 111 were novel. Out-of-sample variance in PSA explained by our new polygenic risk score reached 16.9% (95% CI=16.1%-17.8%) in European ancestry, 9.5% (95% CI=7.0%-12.2%) in African ancestry, 18.6% (95% CI=15.8%-21.4%) in Hispanic/Latino, and 15.3% (95% CI=12.7%-18.1%) in Asian ancestry, and lower for higher age. Our study highlights how including proportionally more participants from underrepresented populations improves genetic prediction of PSA levels, with potential to personalize prostate cancer screening.
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| 4. |
- DeCarolis, Joseph, et al.
(författare)
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Leveraging Open-Source Tools for Collaborative Macro-energy System Modeling Efforts
- 2020
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Ingår i: Joule. - : Elsevier BV. - 2542-4351. ; 4:12, s. 2523-2526
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The authors are founding team members of a new effort to develop an Open Energy Outlook for the United States. The effort aims to apply best practices of policy-focused energy system modeling, ensure transparency, build a networked community, and work toward a common purpose: examining possible US energy system futures to inform energy and climate policy efforts. Individual author biographies can be found on the project website: https://openenergyoutlook.org/. DeCarolis et al. articulate the benefits of forming collaborative teams with a wide array of disciplinary and domain expertise to conduct analysis with macro-energy system models. Open-source models, tools, and datasets underpin such efforts by enabling transparency, accessibility, and replicability among team members and with the broader modeling community.
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| 5. |
- Ellis, A. D., et al.
(författare)
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Future Directions to Realize Ultra-High Bit-Rate Transmission Systems
- 2010
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Ingår i: Proceedings of OptoElectronics and Communications Conference, OECC 2010, Sapporo, Japan, 5-9 July 2010, invited paper..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we examine two potential future directions for the realization of ultra-high bit rate transmission systems.
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| 8. |
- Larsen, Kasper J.
(författare)
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Maximal Unitarity at Two Loops : A New Method for Computing Two-Loop Scattering Amplitudes
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The study of scattering amplitudes beyond one loop is necessary for precision phenomenology for the Large Hadron Collider and may also provide deeper insights into the theoretical foundations of quantum field theory. In this thesis we develop a new method for computing two-loop amplitudes, based on unitarity rather than Feynman diagrams. In this approach, the two-loop amplitude is first expanded in a linearly independent basis of integrals. The process dependence thereby resides in the coefficients of the integrals. These expansion coefficients are then the object of calculation.Our main results include explicit formulas for a subset of the integral coefficients, expressing them as products of tree-level amplitudes integrated over specific contours in the complex plane. We give a general selection principle for determining these contours. This principle is then applied to obtain the coefficients of integrals with the topology of a double box. We show that, for four-particle scattering, each double-box integral in the two-loop basis is associated with a uniquely defined complex contour, referred to as its master contour. We provide a classification of the solutions to setting all propagators of the general double-box integral on-shell. Depending on the number of external momenta at the vertices of the graph, these solutions are given as a chain of pointwise intersecting Riemann spheres, or a torus. This classification is needed to define master contours for amplitudes with arbitrary multiplicities.We point out that a basis of two-loop integrals with as many infrared finite elements as possible allows substantial technical simplications, in terms of obtaining the coefficients of the integrals, as well as for the analytic evaluation of the integrals themselves. We compute two such integrals at four points, obtaining remarkably compact expressions. Finally, we provide a check on a recently developed recursion relation for the all-loop integrand of the amplitudes of N=4 supersymmetric Yang-Mills theory, examining the two-loop six-gluon MHV amplitude and finding agreement. The validity of the approach to two-loop amplitudes developed in this thesis extends to all four-dimensional gauge theories, in particular QCD. The approach is suited for obtaining compact analytical expressions as well as for numerical implementations.
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| 9. |
- Schaetzl, Randall J., et al.
(författare)
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Approaches and challenges to the study of loess : Introduction to the Loess-Fest Special Issue
- 2018
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Ingår i: Quaternary Research. - : Cambridge University Press (CUP). - 0033-5894 .- 1096-0287. ; 89:3, s. 563-618
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In September 2016, the annual meeting of the International Union for Quaternary Research's Loess and Pedostratigraphy Focus Group, traditionally referred to as a LoessFest, met in Eau Claire, Wisconsin, USA. The 2016 LoessFest focused on thin loess deposits and loess transportation surfaces. This LoessFest included 75 registered participants from 10 countries. Almost half of the participants were from outside the United States, and 18 of the participants were students. This review is the introduction to the special issue for Quaternary Research that originated from presentations and discussions at the 2016 LoessFest. This introduction highlights current understanding and ongoing work on loess in various regions of the world and provides brief summaries of some of the current approaches/strategies used to study loess deposits.
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