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Träfflista för sökning "WFRF:(Jude T. C.) "

Sökning: WFRF:(Jude T. C.)

  • Resultat 1-10 av 17
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1.
  • Tidskriftsartikel (refereegranskat)
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2.
  • Engert, Andreas, et al. (författare)
  • The European Hematology Association Roadmap for European Hematology Research : a consensus document
  • 2016
  • Ingår i: Haematologica. - Pavia, Italy : Fondazione Ferrata Storti. - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
  • Tidskriftsartikel (refereegranskat)abstract
    • The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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3.
  • Nanova, M., et al. (författare)
  • Determination of the real part of the η′ -Nb optical potential
  • Ingår i: Physical Review C. - : American Physical Society. - 2469-9985. ; 94:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The excitation function and momentum distribution of η′ mesons have been measured in photoproduction off Nb93 in the energy range of 1.2-2.9 GeV. The experiment has been performed with the combined Crystal Barrel and MiniTAPS detector system, using tagged photon beams from the ELSA electron accelerator. Information on the sign and magnitude of the real part of the η′-Nb potential has been extracted from a comparison of the data with model calculations. An attractive potential of -(41±10(stat)±15(syst)) MeV depth at normal nuclear matter density is deduced within model uncertainties. This value is consistent with the potential depth of -(37±10(stat)±10(syst)) MeV obtained in an earlier measurement for a light nucleus (carbon). This relatively shallow η′-nucleus potential will make the search for η′-nucleus bound states more difficult.
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4.
  • Müller, J., et al. (författare)
  • New data on γ→p→→ηp with polarized photons and protons and their implications for N⁎ → Nη decays
  • Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier. - 0370-2693. ; 803
  • Tidskriftsartikel (refereegranskat)abstract
    • The polarization observables T,E,P,H, and G in photoproduction of η mesons off protons are measured for photon energies from threshold to W=2400 MeV (T), 2280 MeV (E), 1620 MeV (P,H), or 1820 MeV (G), covering nearly the full solid angle. The data are compared to predictions from the SAID, MAID, JüBo, and BnGa partial-wave analyses. A refit within the BnGa approach including further data yields precise branching ratios for the Nη decay of nucleon resonances. A Nη-branching ratio of 0.33±0.04 for N(1650)1/2− is found, which reduces the large and controversially discussed Nη-branching ratio difference of the two lowest mass JP=1/2−-resonances significantly.
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5.
  • Aguar-Bartolome, P., et al. (författare)
  • New determination of the eta transition form factor in the Dalitz decay eta -> e(+) e(-) gamma with the Crystal Ball/TAPS detectors at the Mainz Microtron
  • 2014
  • Ingår i: Physical Review C (Nuclear Physics). - : American Physical Society. - 0556-2813. ; 89:4
  • Tidskriftsartikel (refereegranskat)abstract
    • The Dalitz decay eta -> e(+) e(-) gamma has been measured in the gamma p -> eta p reaction with the Crystal Ball and TAPS multiphoton spectrometers, together with the photon-tagging facility at the Mainz Microtron MAMI. The experimental statistic used in this work is one order of magnitude greater than in any previous measurement of eta -> e(+) e(-) gamma. The value obtained for the slope parameter Lambda(-2) of the eta transition form factor, Lambda(-2) = (1.95 +/- 0.15(stat) +/- 0.10(syst)) GeV-2, is in good agreement with recent measurements conducted in eta -> e(+) e(-) gamma and eta -> mu(+) mu(-) gamma decays, as well as with recent form-factor calculations. The uncertainty obtained in the value of Lambda(-2) is lower compared to results from previous measurements of the eta -> e(+) e(-) gamma decay.
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6.
  • Leo, Veronica De, et al. (författare)
  • Recent results of the BGO-OD experiment at ELSA facility
  • 2013
  • Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588. ; 424:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The results obtained at the BGO-OD experiment with the BGO calorimeter, equipped with the new electronic readout based on sampling ADCs, during the tests performed with the beam time of March and June 2012 are presented. The proper functioning of the apparatus has allowed the reconstruction of the pseudo-scalar mesons π0 and η invariant masses. The simulation of the η' photoproduction reaction prepared for a proposal to the joint ELSA-MAMI Physics Advisory Committee is also presented.
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7.
  • Mansouri, Larry, et al. (författare)
  • Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
  • 2016
  • Ingår i: ; 128:23, s. 2666-2670
  • Tidskriftsartikel (refereegranskat)abstract
    • We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBϵ, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Preliminary data indicate enrichment of NFKBIE aberrations in other lymphoid malignancies, hence we screened a large patient cohort (n=1460) diagnosed with different lymphoid neoplasms. While NFKBIE deletions were infrequent in follicular lymphoma, splenic marginal-zone lymphoma, and T-cell acute lymphoblastic leukemia (<2%), slightly higher frequencies were seen in diffuse large B-cell lymphoma, mantle cell lymphoma, and primary CNS lymphoma (3-4%). In contrast, a remarkably high frequency of NFKBIE aberrations (46/203 cases, 22.7%) was observed in primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (3/11 cases, 27.3%). NFKBIE-deleted PMBL patients were more often therapy-refractory (P=.022) and displayed inferior outcome compared to wildtype patients (5-year survival: 59% vs. 78%; P=.034); however they appeared to benefit from radiotherapy (P=.022) and rituximab-containing regimens (P=.074). NFKBIEaberrations remained an independent factor in multivariate analysis (P=.003), also when restricting to immunochemotherapy-treated patients (P=.008). Whole-exome sequencing and gene expression-profiling verified the importance of NF-κB deregulation in PMBL. In summary, we identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL.
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8.
  • Nanova, M., et al. (författare)
  • The η′-carbon potential at low meson momenta
  • Ingår i: European Physical Journal A. - : Springer. - 1434-6001. ; 54:10
  • Tidskriftsartikel (refereegranskat)abstract
    • The production of η′ mesons in coincidence with forward-going protons has been studied in photon-induced reactions on 12 C and on a liquid hydrogen (LH 2 ) target for incoming photon energies of 1.3–2.6 GeV at the electron accelerator ELSA. The η′ mesons have been identified via the η′ → π 0 π 0 η → 6γ decay registered with the CBELSA/TAPS detector system. Coincident protons have been identified in the MiniTAPS BaF 2 array at polar angles of 2°≤ θ p ≤ 11°. Under these kinematic constraints the η′ mesons are produced with relatively low kinetic energy (≈ 150 MeV) since the coincident protons take over most of the momentum of the incident-photon beam. For the C-target this allows the determination of the real part of the η′-carbon potential at low meson momenta by comparing with collision model calculations of the η′ kinetic energy distribution and excitation function. Fitting the latter data for η′ mesons going backwards in the center-of-mass system yields a potential depth of V = −(44 ± 16(stat) ± 15(syst)) MeV, consistent with earlier determinations of the potential depth in inclusive measurements for average η′ momenta of ≈ 1.1 GeV/c. Within the experimental uncertainties, there is no indication of a momentum dependence of the η′-carbon potential. The LH 2 data, taken as a reference to check the data analysis and the model calculations, provide differential and integral cross sections in good agreement with previous results for η′ photoproduction off the free proton.
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9.
  • Aguar-Bartolome, P., et al. (författare)
  • Measurement of the gamma p -> K-0 Sigma(+) reaction with the Crystal Ball/TAPS detectors at the Mainz Microtron
  • 2013
  • Ingår i: Physical Review C (Nuclear Physics). - : American Physical Society. - 0556-2813. ; 88:4
  • Tidskriftsartikel (refereegranskat)abstract
    • The gamma p -> K-0 Sigma(+) reaction has been measured from threshold to E-gamma = 1.45 GeV (W-CM = 1.9 GeV) using the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. In the present experiment, this reaction was searched for in the 3 pi(0)p final state, by assuming K-S(0) -> pi(0)pi(0) and Sigma(+) -> pi(0)p. The experimental results include total and differential cross sections as well as the polarization of the recoil hyperon. The new data significantly improve empirical knowledge about the gamma p -> K-0 Sigma(+) reaction in the measured energy range. The results are compared to previous measurements and model predictions. It is demonstrated that adding the present gamma p -> K-0 Sigma(+) results to existing data allowed a better description of this reaction with various models.
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10.
  • Bantes, B., et al. (författare)
  • The BGO calorimeter of BGO-OD experiment
  • 2015
  • Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588. ; 587:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The BGO Rugby Ball is a large solid angle electromagnetic calorimeter now installed in the ELSA Facility in Bonn. The BGO is operating in the BGO-OD experiment aiming to study meson photoproduction off proton and neutron induced by a Bremsstrahlung polarized gamma beam of energies from 0.2 to 3.2 GeV and an intensity of 5 × 107 photons per second. The scintillating material characteristics and the photomultiplier read-out make this detector particularly suited for the detection of medium energy photons and electrons with very good energy resolution. The detector has been equipped with a new electronics read-out system, consisting of 30 sampling ADC Wie-Ne-R modules which perform the off-line reconstruction of the signal start-time allowing for a good timing resolution. Performances in linearity, resolution and time response have been carefully tested at the Beam Test Facility of the INFN National Laboratories in Frascati by using a matrix of 7 BGO crystals coupled to photomultipliers and equipped with the Wie-Ne-R sampling ADCs.
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