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| 2. |
- Gudmundsdottir, Anna, et al.
(författare)
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The type and timing of patent ductus arteriosus treatment was associated with neurodevelopment when extremely preterm infants reached 6.5 years
- 2021
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Ingår i: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253 .- 1651-2227. ; 110:2, s. 510-520
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This study investigated patent ductus arteriosus (PDA) treatment and neurodevelopmental outcomes when extremely preterm born children reached 6.5 years. Method: Our cohort was 435 children with neonatal PDA treatment data and neurodevelopmental follow-up data, born in 2004-2007, who participated in the Extremely Preterm Infants in Sweden Study. Pharmacological or surgical PDA treatment and the age at PDA treatment, were investigated in relation to the risks of moderate to severe neurodevelopmental impairment (NDI) and full-scale intelligence quotient (FSIQ) at 6.5 years. Results: The children who received PDA drug treatment, including those who also had surgery, had the same risk of moderate to severe NDI or lower FSIQ as untreated children. However, children who had primary PDA surgery faced increased risks of NDI, with an adjusted incidence rate ratio of 1.62 (95% confidence interval [CI] 1.28-2.06) and a lower adjusted mean difference FSIQ of −7.1 (95% CI −11 to −3.2). Surgery at less than 10 days of life was associated with a significantly increased risk of moderate to severe NDI and lower FSIQ than surgery after 20 days. Conclusion: Drug treatment followed by deferred surgery appeared to be a safer option for extremely preterm infants severely affected by PDA.
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| 3. |
- Håkansson, Stellan, et al.
(författare)
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Group B streptococcal carriage in Sweden : a national study on risk factors for mother and infant colonisation
- 2008
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - Stockholm : Wiley. - 0001-6349 .- 1600-0412. ; 87:1, s. 50-58
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Tidskriftsartikel (refereegranskat)abstract
- Background. To study group B streptococcus (GBS) colonisation in parturients and infants in relation to obstetric outcome and to define serotypes and antibiotic resistance in GBS isolates acquired. Methods. A population-based, national cohort of parturients and their infants was investigated. During 1 calendar week in 2005 all women giving birth (n=1,754) were requested to participate in the study. Results. A total of 1,569 mother/infant pairs with obstetric and bacteriological data were obtained. Maternal carriage rate was 25.4% (95% confidence interval (CI): 23.3-27.6). In GBS-positive mothers with vaginal delivery and no intrapartum antibiotics, the infant colonisation rate was 68%. Some 30% of infants were colonised after acute caesarean section, and 0% were colonised after an elective procedure. Duration of transport of maternal recto/vaginal swabs of more than 1 day impeded culture sensitivity. Infant mMales were more frequently colonised than females (76.9 versus 59.8%, odds ratio (OR): 2.16; 95% CI: 1.27-3.70), as were infants born after rupture of membranes ≥24 h (p =0.039). Gestational age, birth weight and duration of labor did not significantly influence infant colonisation. Some 30% of parturients with at least one risk factor for neonatal disease received intrapartum antibiotics. The most common GBS serotypes were type III and V. Some 5% of the isolates were resistant to clindamycin and erythromycin, respectively. Conclusions. Maternal GBS prevalence and infant transfer rate were high in Sweden. Males were more frequently colonised than females. The sensitivity of maternal cultures decreased with the duration of sample transport. Clindamycin resistance was scarce. The use of intrapartum antibiotics was limited in parturients with obstetric risk factors for early onset group B streptococcal disease.
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| 4. |
- Källén, Anna, 1973-
(författare)
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And Through Flows the River : Archaeology and the Pasts of Lao Pako
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This is a story about Lao Pako. Lao Pako is located on a small hill on the southern bank of the river Nam Ngum in central Laos. Four seasons of archaeological fieldwork have yielded considerable amounts of pottery, metallurgical remains, glass beads, stone artefacts, spindle whorls as well as other material and structural information that have created a foundation for interpretation. The archaeological interpretation presents Lao Pako as a place where people came to perform rituals c. 1500 years ago. In these rituals, sophisticated combinations of pottery depositions, infant burials and iron production produced a narrative about what it means to be in the world. Things in and on the ground created, and continue to create, non-verbal sentences about life and death, fertility, decay and worldly reproduction. The archaeological interpretation is, however, not the only valid story about Lao Pako. This is a place where spirits are; it is also a tourist resort and a national treasure. These other stories all work to create Lao Pako as a place of interest and are used in this thesis to define the archaeological story, and to visualize the aims and agendas inherent in the production of archaeological knowledge. Using the conceptual apparatus of postcolonial and other critical theory, the thesis aims to critically deconstruct the archaeology performed by the author and others. It entails an explicit critique of the deterministic temporal unilinearity that is inherent in the archaeological narrative of the evolution of humankind, as well as against essentialist notions of culture and the dissociation of the past as exotic otherness. Thus, the stories about Lao Pako demonstrate the need to critically revise the role of archaeology in a postcolonial world, and create archaeological stories by which we are touched, moved and disturbed, without resorting to imperialist notions of time and progress.
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| 5. |
- Källén, Anna, et al.
(författare)
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Archaeogenetics in Popular Media : Contemporary Implications of Ancient DNA
- 2019
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Ingår i: Current Swedish Archaeology. - 1102-7355. ; 27, s. 69-91
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Tidskriftsartikel (refereegranskat)abstract
- If most academic debates surrounding the recent boom of ancient DNA (aDNA) so far have concerned conflicting research epistemologies, this article is a call for taking aspects of media and communication more seriously. Analyzing the fates of two recent research papers on Viking Age Scandinavia, we show how aDNA research is communicated, narrated and infused with meaning in the public sphere, particularly in relation to popular narratives and political debates. We observe significant interlacing of scientific, political and media discourses in and around the papers, and conclude that archaeogenetics is a highly mediatized scientific field.
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| 6. |
- Källén, Anna, 1973-, et al.
(författare)
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Introduction : Transcending the aDNA Revolution
- 2021
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Ingår i: Journal of social archaeology. - : SAGE Publications. - 1469-6053 .- 1741-2951. ; 21:2, s. 149-156
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Tidskriftsartikel (refereegranskat)abstract
- Over the past decade, technological developments known as “next-generation sequencing” have enabled genome-wide analyses of ancient DNA (aDNA) to take place more quickly and cheaply than before. These developments have had important consequences for archaeological knowledge and practice, most notably in the rapidly growing field of archaeogenomics (also referred to as archaeogenetics or paleogenomics).
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| 7. |
- Lundgren, Pia, 1967-, et al.
(författare)
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WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants
- 2013
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Ingår i: PLOS ONE. - San Francisco : Public Library of Science, PLoS. - 1932-6203. ; 8:9
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate the ability of a postnatal weight-gain algorithm (WINROP) to identify sight-threatening retinopathy of prematurity (ROP type 1) in a nation-based extremely preterm infant cohort.METHODS: This study enrolled all 707 live-born extremely preterm (gestational age [GA] <27 weeks) infants, born 2004-2007 in Sweden; the Extremely preterm Infants in Sweden Study (EXPRESS). WINROP analysis was performed retrospectively in 407 of the infants using weekly weight gain to assess the preterm infant's risk of developing ROP type 1 requiring treatment. GA, birthweight (BW), and weekly postnatal weight measurements were entered into WINROP. WINROP signals with an alarm to indicate if the preterm infant is at risk for ROP type 1.RESULTS: In this extremely preterm population, WINROP correctly identified 96% (45/47) of the infants who required treatment for ROP type 1. The median time from alarm to treatment was 9 weeks (range, 4-20 weeks).CONCLUSIONS: WINROP, an online surveillance system using weekly weight gain, identified extremely preterm infants at risk for ROP type 1 requiring treatment at an early stage and with high sensitivity in a Swedish nation-based cohort.
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| 8. |
- Norman, Mikael, et al.
(författare)
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The Swedish Neonatal Quality Register - contents, completeness and validity
- 2019
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Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 108:8, s. 1411-1418
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined cross-linking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years.Results: In total, 84 712 infants were hospitalised. A total of 52 806 infants occurred in both SNQ and the population registers; 28 692 were only found in the population registers, and 3214 infants were only found in SNQ. Between gestational weeks 24-34, completeness of SNQ was 98-99%. Below and above these gestational ages, completeness was lower. Infants missing in SNQ were term or near-term in 99% of the cases, and their diagnoses indicated conditions managed in maternity units, or re-admissions for acute infections, managed in paediatric units. For most diagnoses, the agreement between SNQ and population registers was high, but some (bronchopulmonary dysplasia and grade of hypoxic-ischaemic encephalopathy) were often missing in the population registers.Conclusion: SNQ completeness and agreement against other registers, especially for preterm infants, is excellent. SNQ is a valid tool for benchmarking, quality improvement and research.
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| 9. |
- Strand, Daniel, 1984-
(författare)
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I am a Viking! : DNA, popular culture and the construction of geneticized identity
- 2021
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Ingår i: New genetics and society (Print). - : Taylor & Francis. - 1463-6778 .- 1469-9915. ; 40:4, s. 520-540
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we analyze how genetic genealogy reshapes popular notions of historical identity, as it facilitates a genetically informed understanding of ethnicity and ancestry. Drawing on interviews with Swedish, British and American individuals who have employed genetic ancestry tests (GATs) to prove ancestral connections to Vikings, we explore how the desire to “be a Viking” is articulated through a convergence of pre-existing discourses around Vikings and DNA. By combining signs from genetic science and popular depictions of Vikings, our interviewees create a new discourse of geneticized Viking identity. In this new discourse, socio-historically constructed ideas about Vikings are naturalized as the innate qualities of individuals who possess a certain genetic composition. Images of “the Viking” once created for political, cultural or commercial purposes are revived in new embodied forms and can start to circulate in new social contexts, where they, by association, appear to be confirmed by genetical science.
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