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- Neuzil, Jiri, 1958-, et al.
(författare)
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Vitamin E analogs : A new class of multiple action agents with anti-neoplastic and anti-atherogenic activity
- 2002
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Ingår i: Apoptosis (London). - 1360-8185 .- 1573-675X. ; 7:2, s. 179-187
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Tidskriftsartikel (refereegranskat)abstract
- The incidence of cancer and atherosclerosis, two most common causes of death in developed countries, has been stagnating or, even, increasing. Drugs effective against such conditions are needed and, in this regard, the potential anti-atherosclerotic activity of vitamin E analogs has been studied extensively. Surprisingly, recent results indicate that these agents may also exert anti-neoplastic effects. Here we review the evidence that particular analogs of vitamin E may act as both anti-atherogenic and anti-cancer agents, and discuss the possible molecular bases for these actions.
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| 2. |
- Terman, Alexei, 1957-, et al.
(författare)
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Decreased apoptotic response of inclusion-cell disease fibroblasts : A consequence of lysosomal enzyme missorting?
- 2002
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Ingår i: Experimental Cell Research. - : Elsevier BV. - 0014-4827 .- 1090-2422. ; 274:1
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Tidskriftsartikel (refereegranskat)abstract
- To better understand the role of lysosomes in apoptosis, we compared the responses to apoptotic stimuli of normal fibroblasts with those of inclusion cells (I-cells), i.e., fibroblasts with impaired function of lysosomal enzymes due to their missorting and ensuing nonlysosomal localization. Although both cell types did undergo apoptosis when exposed to the lysosomotropic detergent MSDH, the redox-cycling quinone naphthazarin, or the protein kinase inhibitor staurosporine, I-cells exerted a markedly decreased response to these agonists than did normal fibroblasts. Furthermore, leupeptin and pepstatin A (inhibitors of cysteine and aspartic proteases, respectively) suppressed staurosporine-induced apoptosis of normal fibroblasts, whereas survival of I-cells was unaffected. These findings give further support for the involvement of lysosomal enzymes in apoptosis and suggest I-cells as a suitable model for studying the role of lysosomes in programmed cell death.
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