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Träfflista för sökning "WFRF:(Kalafati Ioanna P.) ;pers:(Hoffmann Wolfgang)"

Search: WFRF:(Kalafati Ioanna P.) > Hoffmann Wolfgang

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1.
  • Shungin, Dmitry, et al. (author)
  • New genetic loci link adipose and insulin biology to body fat distribution.
  • 2015
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
  • Journal article (peer-reviewed)abstract
    • Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
  •  
2.
  • Smith, Jennifer A, et al. (author)
  • Genome-wide association study identifies 74 loci associated with educational attainment
  • 2016
  • In: Nature (London). - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 533:7604, s. 539-542
  • Journal article (peer-reviewed)abstract
    • Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
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Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Salomaa, Veikko (2)
Perola, Markus (2)
Campbell, Harry (2)
Rudan, Igor (2)
Staessen, Jan A (2)
Deloukas, Panos (2)
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Amin, Najaf (2)
van Duijn, Cornelia ... (2)
Magnusson, Patrik K ... (2)
Pedersen, Nancy L (2)
Lehtimäki, Terho (2)
Thorleifsson, Gudmar (2)
Thorsteinsdottir, Un ... (2)
Stefansson, Kari (2)
Verweij, Niek (2)
Mangino, Massimo (2)
Gieger, Christian (2)
Strauch, Konstantin (2)
Nyholt, Dale R. (2)
Spector, Tim D. (2)
Kaprio, Jaakko (2)
Samani, Nilesh J. (2)
Vonk, Judith M (2)
Metspalu, Andres (2)
Wilson, James F. (2)
Eriksson, Johan G. (2)
Montgomery, Grant W. (2)
Jöckel, Karl-Heinz (2)
Harris, Tamara B (2)
Homuth, Georg (2)
Hofman, Albert (2)
Uitterlinden, André ... (2)
Hayward, Caroline (2)
Gudnason, Vilmundur (2)
van der Harst, Pim (2)
Schlessinger, David (2)
Kanoni, Stavroula (2)
Hyppönen, Elina (2)
Milani, Lili (2)
Esko, Tõnu (2)
Visscher, Peter M. (2)
Vollenweider, Peter (2)
Feitosa, Mary F. (2)
Yang, Jian (2)
Eklund, Niina (2)
Teumer, Alexander (2)
Franke, Lude (2)
Kraja, Aldi T. (2)
Mihailov, Evelin (2)
Borecki, Ingrid B. (2)
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University
University of Gothenburg (2)
Uppsala University (2)
Karolinska Institutet (2)
Umeå University (1)
Lund University (1)
Stockholm School of Economics (1)
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Högskolan Dalarna (1)
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Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Natural sciences (1)

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