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Gene x dietary pattern interactions in obesity : analysis of up to 68 317 adults of European ancestry

Nettleton, Jennifer A (author)
Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA.
Follis, Jack L (author)
Univ St Thomas, Dept Math, Houston, TX 77006 USA.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
Ngwa, Julius S (author)
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.
show more...
Smith, Caren E (author)
Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA USA.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
Ahmad, Shafqat (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.
Tanaka, Toshiko (author)
NIA, Clin Res Branch, Baltimore, MD 21224 USA.
Kristiansson, Kati (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.,Natl Inst Hlth & Welf, Unit Publ Hlth Genom, Helsinki 00290, Finland.,Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC USA.
Voortman, Trudy (author)
Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.
Lemaitre, Rozenn N (author)
Univ Washington, Dept Med, Seattle, WA 98195 USA.
Kristiansson, Kati (author)
Nuotio, Marja-Liisa (author)
Natl Inst Hlth & Welf, Unit Publ Hlth Genom, Helsinki 00290, Finland.;Univ Helsinki, Inst Mol Med Finland FIMM, FIN-00290 Helsinki, Finland.
Houston, Denise K (author)
Perälä, Mia-Maria (author)
Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00290, Finland.
Qi, Qibin (author)
Harvard Univ, Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Albert Einstein Coll Med, Dept Epidemiol & Publ Hlth, Bronx, NY 10467 USA.
Sonestedt, Emily (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
Manichaikul, Ani (author)
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.;Univ Virginia, Dept Publ Hlth Sci, Div Biostat & Epidemiol, Charlottesville, VA USA.
Kanoni, Stavroula (author)
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
Ganna, Andrea (author)
Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.,NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
Mikkilä, Vera (author)
Univ Helsinki, Dept Food & Environm Sci, Helsinki, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
North, Kari E (author)
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.;Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.
Siscovick, David S (author)
New York Acad Med, New York, NY USA.
Harald, Kennet (author)
THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.
Mckeown, Nicola M (author)
Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA USA.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
Johansson, Ingegerd (author)
Umeå universitet,Institutionen för odontologi,Näringsforskning,Umea Univ, Dept Odontol, Umea, Sweden.
Rissanen, Harri (author)
THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.
Liu, Yongmei (author)
Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
Lahti, Jari (author)
Univ Helsinki, Inst Behav Sci, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.
Hu, Frank B (author)
Harvard Univ, Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
Bandinelli, Stefania (author)
ASF, Geriatr Unit, Florence, Italy.
Rukh, Gull (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
Rich, Stephen (author)
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
Booij, Lisanne (author)
NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
Dmitriou, Maria (author)
Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
Ax, Erika (author)
Uppsala universitet,Klinisk nutrition och metabolism
Raitakari, Olli (author)
Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.;Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland.
Mukamal, Kenneth (author)
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
Männistö, Satu (author)
Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00290, Finland.
Hallmans, Göran (author)
Umeå universitet,Enheten för biobanksforskning,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden.
Jula, Antti (author)
THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.,Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.
Ericson, Ulrika (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
Jacobs, David R, Jr (author)
Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
Van Rooij, Frank J A (author)
Deloukas, Panos (author)
Wellcome Trust Sanger Inst, Hinxton, Cambs, England.
Sjögren, Per (author)
Uppsala universitet,Klinisk nutrition och metabolism
Kähönen, Mika (author)
Univ Tampere, Dept Clin Physiol, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Tampere, Finland.
Djousse, Luc (author)
Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Boston VA Healthcare Syst, Boston, MA USA.
Perola, Markus (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Natl Inst Hlth & Welf, Unit Publ Hlth Genom, Helsinki 00290, Finland.;Univ Helsinki, Inst Mol Med Finland FIMM, FIN-00290 Helsinki, Finland.;Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.,NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
Barroso, Inês (author)
Wellcome Trust Sanger Inst, Metab Dis Grp, Hinxton, Cambs, England.;Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 2QQ, England.
Hofman, Albert (author)
Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.
Stirrups, Kathleen (author)
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
Viikari, Jorma (author)
Univ Turku, Dept Med, Turku, Finland.;Turku Univ Hosp, Div Med, FIN-20520 Turku, Finland.
Uitterlinden, André G (author)
Kalafati, Ioanna P (author)
Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
Franco, Oscar H. (author)
Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.
Mozaffarian, Dariush (author)
Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
Salomaa, Veikko (author)
THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.
Borecki, Ingrid B (author)
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
Knekt, Paul (author)
THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.
Kritchevsky, Stephen B (author)
Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC USA.
Eriksson, Johan G (author)
Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00290, Finland.;Univ Helsinki, Inst Clin Med, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.;Helsinki Univ Cent Hosp, Unit Gen Practice, Helsinki, Finland.
Dedoussis, George V (author)
Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
Qi, Lu (author)
Harvard Univ, Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
Ferrucci, Luigi (author)
NIA, Clin Res Branch, Baltimore, MD 21224 USA.
Orho-Melander, Marju (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease,Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
Zillikens, M Carola (author)
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Lehtimäki, Terho (author)
Univ Tampere, Dept Clin Chem, Fimlab Labs, FIN-33101 Tampere, Finland.;Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.
Renström, Frida (author)
Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Näringsforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.;Umea Univ, Dept Biobank Res, Umea, Sweden.
Cupples, L Adrienne (author)
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.
Loos, Ruth J F (author)
Franks, Paul W (author)
Lund University,Lunds universitet,Umeå universitet,Medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Sweden; Department of Nutrition, Harvard Chan School of Public Health, Boston, MA, USA,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.;Harvard Univ, Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
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Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA Univ St Thomas, Dept Math, Houston, TX 77006 USA. (creator_code:org_t)
2015-05-20
2015
English.
In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 24:16, s. 4728-4738
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Obesity is highly heritable. Genetic variants showing robust associationswith obesity traits have been identified through genome wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphismswere genotyped, and genetic risk scores (GRS) were calculated in 18 cohorts of European ancestry (n = 68 317). Diet score was calculated based on self-reported intakes of whole grains, fish, fruits, vegetables, nuts/seeds (favorable) and red/processed meats, sweets, sugar-sweetened beverages and fried potatoes (unfavorable). Multivariable adjusted, linear regression within each cohort followed by inverse variance-weighted, fixed-effects meta-analysis was used to characterize: (a) associations of each GRS with BMI and BMI-adjustedWHR and (b) diet score modification of genetic associations with BMI and BMI-adjusted WHR. Nominally significant interactions (P = 0.006-0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjustedWHR or BMI outcomes. Although the magnitudes of these select interactions were small, our data indicated that associations between genetic predisposition and obesity traits were stronger with a healthier diet. Our findings generate interesting hypotheses; however, experimental and functional studies are needed to determine their clinical relevance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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Nettleton, Jenni ...
Follis, Jack L
Ngwa, Julius S
Smith, Caren E
Ahmad, Shafqat
Tanaka, Toshiko
show more...
Kristiansson, Ka ...
Voortman, Trudy
Lemaitre, Rozenn ...
Nuotio, Marja-Li ...
Houston, Denise ...
Perälä, Mia-Mari ...
Qi, Qibin
Sonestedt, Emily
Manichaikul, Ani
Kanoni, Stavroul ...
Ganna, Andrea
Mikkilä, Vera
North, Kari E
Siscovick, David ...
Harald, Kennet
Mckeown, Nicola ...
Johansson, Ingeg ...
Rissanen, Harri
Liu, Yongmei
Lahti, Jari
Hu, Frank B
Bandinelli, Stef ...
Rukh, Gull
Rich, Stephen
Booij, Lisanne
Dmitriou, Maria
Ax, Erika
Raitakari, Olli
Mukamal, Kenneth
Männistö, Satu
Hallmans, Göran
Jula, Antti
Ericson, Ulrika
Jacobs, David R, ...
Van Rooij, Frank ...
Deloukas, Panos
Sjögren, Per
Kähönen, Mika
Djousse, Luc
Perola, Markus
Barroso, Inês
Hofman, Albert
Stirrups, Kathle ...
Viikari, Jorma
Uitterlinden, An ...
Kalafati, Ioanna ...
Franco, Oscar H.
Mozaffarian, Dar ...
Salomaa, Veikko
Borecki, Ingrid ...
Knekt, Paul
Kritchevsky, Ste ...
Eriksson, Johan ...
Dedoussis, Georg ...
Qi, Lu
Ferrucci, Luigi
Orho-Melander, M ...
Zillikens, M Car ...
Ingelsson, Erik
Lehtimäki, Terho
Renström, Frida
Cupples, L Adrie ...
Loos, Ruth J F
Franks, Paul W
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