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Träfflista för sökning "WFRF:(Kanduri Meena) ;pers:(Kogner Per)"

Search: WFRF:(Kanduri Meena) > Kogner Per

  • Result 1-3 of 3
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1.
  • Mondal, Tanmoy, 1981, et al. (author)
  • Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis
  • 2018
  • In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:3
  • Journal article (peer-reviewed)abstract
    • Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies.
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2.
  • Pandey, Gaurav Kumar, et al. (author)
  • The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.
  • 2014
  • In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 26:5, s. 722-737
  • Journal article (peer-reviewed)abstract
    • Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
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  • Result 1-3 of 3
Type of publication
journal article (2)
other publication (1)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Kogner, Per (3)Undo refine
Mitra, Sanhita (3)
Martinsson, Tommy, 1 ... (2)
Kanduri, Chandrasekh ... (2)
Akyürek, Levent, 196 ... (2)
Bandaru, Sashidar (2)
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Kanduri, Meena, 1974 (2)
Subhash, Santhilal, ... (2)
Mondal, Tanmoy, 1981 (2)
Fischer, Matthias (2)
Hertwig, Falk (2)
Pandey, Gaurav Kumar (2)
Ganeshram, Abiarchan ... (2)
Carén, Helena, 1979 (1)
Kirkeby, Agnete (1)
Abrahamsson, Jonas, ... (1)
Fransson, Susanne, 1 ... (1)
Abrahamsson, Jonas (1)
Larsson, Erik (1)
Kanduri, Chandrasekh ... (1)
Larsson, Erik, 1975 (1)
Kosalai, Subazini Th ... (1)
Mishra, Kankadeb, 19 ... (1)
Östensson, Malin, 19 ... (1)
Martinsson, Tommy (1)
Juvvuna, Prasanna Ku ... (1)
Huarte, Maite (1)
Pfeifer, Susan (1)
Fransson, Susanne (1)
Miranda, Caroline (1)
Hedborg, Fredrik (1)
Shi, Leming (1)
Mishra, Kankadeb (1)
Pfeifer, Susan, 1948 ... (1)
Deland, Lily (1)
Subhash, Santhilal (1)
Bartsch, Deniz (1)
Kurian, Leo (1)
Mondal, Tanmoy (1)
Kanduri, Meena (1)
Bartenhagen, Christo ... (1)
Traxler, Larissa (1)
Wernig-Zorc, Sara (1)
Volland, Ruth (1)
Engesser, Anne (1)
Peng, Zhiyu (1)
Hedborg, Fredrik, 19 ... (1)
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University
University of Gothenburg (2)
Uppsala University (2)
Karolinska Institutet (2)
Lund University (1)
Chalmers University of Technology (1)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Natural sciences (1)

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