| 1. |
|
|
| 2. |
- Bill-Axelson, Anna, et al.
(författare)
-
Radical prostatectomy versus watchful waiting in localized prostate cancer : the Scandinavian prostate cancer group-4 randomized trial
- 2008
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 100:16, s. 1144-1154
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The benefit of radical prostatectomy in patients with early prostate cancer has been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up.METHODS: From October 1, 1989, through February 28, 1999, 695 men with clinically localized prostate cancer were randomly assigned to radical prostatectomy (n = 347) or watchful waiting (n = 348). Follow-up was complete through December 31, 2006, with histopathologic review and blinded evaluation of causes of death. Relative risks (RRs) were estimated using the Cox proportional hazards model. Statistical tests were two-sided.RESULTS: During a median of 10.8 years of follow-up (range = 3 weeks to 17.2 years), 137 men in the surgery group and 156 in the watchful waiting group died (P = .09). For 47 of the 347 men (13.5%) who were randomly assigned to surgery and 68 of the 348 men (19.5%) who were not, death was due to prostate cancer. The difference in cumulative incidence of death due to prostate cancer remained stable after about 10 years of follow-up. At 12 years, 12.5% of the surgery group and 17.9% of the watchful waiting group had died of prostate cancer (difference = 5.4%, 95% confidence interval [CI] = 0.2 to 11.1%), for a relative risk of 0.65 (95% CI = 0.45 to 0.94; P = .03). The difference in cumulative incidence of distant metastases did not increase beyond 10 years of follow-up. At 12 years, 19.3% of men in the surgery group and 26% of men in the watchful waiting group had been diagnosed with distant metastases (difference = 6.7%, 95% CI = 0.2 to 13.2%), for a relative risk of 0.65 (95% CI = 0.47 to 0.88; P = .006). Among men who underwent radical prostatectomy, those with extracapsular tumor growth had 14 times the risk of prostate cancer death as those without it (RR = 14.2, 95% CI = 3.3 to 61.8; P < .001).CONCLUSION: Radical prostatectomy reduces prostate cancer mortality and risk of metastases with little or no further increase in benefit 10 or more years after surgery.
|
|
| 3. |
- Frick, Matilda, 1979-, et al.
(författare)
-
Elever med adhd och autism : psykologiska och pedagogiska perspektiv
- 2023
-
Bok (populärvet., debatt m.m.)abstract
- Boken presenterar konkreta strategier som kan användas i klassrummet för att främja lärande och delaktighet hos elever med adhd och autism.I den första delen, Psykologiska perspektiv, beskrivs diagnoskriterier, utredningsprocessen, hur adhd och autism uttrycks i vardagen samt en rad sociala och kognitiva förklaringsmodeller som är relaterade till tillstånden.Den andra delen, Pedagogiska perspektiv, knyter de psykologiska teorierna till olika vardagssituationer i skolan och redogör för olika strategier för stöd, såsom ledarskap i klassrummet, struktur i tid och rum, stöd för motivation, lärande och kamratrelationer. Boken riktar sig till specialpedagoger, speciallärare, lärare och skolpsykologer verksamma i skolan.
|
|
| 4. |
- Garg, K. K., et al.
(författare)
-
Jatropha production on wastelands in India: opportunities and trade-offs for soil and water management at the watershed scale
- 2011
-
Ingår i: Biofuels, Bioproducts and Biorefining. - : Wiley. - 1932-1031 .- 1932-104X. ; 5:4, s. 410-430
-
Tidskriftsartikel (refereegranskat)abstract
- Biofuel production from feedstocks grown on wastelands is considered a means of addressing concerns about climate change and improving energy security while at the same time providing an additional source of income for the land users. The establishment of biomass plantations on wastelands is likely to affect local livelihoods and can affect surrounding ecosystems by influencing hydrologic flows and processes such as erosion. We present an assessment of Jatropha plantation establishment on wastelands, using the ArcSWAT modeling tool. The assessment was made for a wasteland located in the Velchal watershed, Andhra Pradesh, India, which recently was converted to a biofuel plantation with Jatropha. The previous land use, in this case grazing, could continue in the Jatropha plantations. Several desirable effects occurred as a result of the land-use conversion: non-productive soil evaporation was reduced as a larger share of the rainfall was channeled to productive plant transpiration and groundwater recharge, and at the same time a more stable (less erosive) runoff resulted in reduced soil erosion and improved downstream water conditions. A win-win situation between improved land productivity and soil carbon content was observed for the Jatropha plantations. On the other hand, the results indicate that at the sub-basin scale, reductions in runoff generation as a result of large-scale conversion of wastelands to Jatropha cropping may pose problems to downstream water users and ecosystems. From a livelihoods perspective, Jatropha production was generally positive, creating a complementary source of income to the farmers, thus strengthening the resilience of the local community. In the future, the potential gain from Jatropha cropping is expected to increase as cropping systems improve and growing biofuel markets result in better conditions for biofuel producers.
|
|
| 5. |
- Hultin, H., et al.
(författare)
-
Psychometric Properties of an Instrument to Measure Social and Pedagogical School Climate Among Teachers (PESOC)
- 2018
-
Ingår i: Scandinavian Journal of Educational Research. - : Informa UK Limited. - 0031-3831 .- 1470-1170. ; 62:2, s. 287-306
-
Tidskriftsartikel (refereegranskat)abstract
- This study investigated the psychometric properties of a teacher-reported version of a Swedish school climate instrument called the Pedagogical and Social Climate (PESOC), which consists of 95 items covering cultural, structural and social factors. A sample of 348 teachers from 19 Swedish secondary schools was used. Multilevel confirmatory factor analysis conducted within a structural equation modelling framework indicated that the PESOC had a two-factor structure at the teacher level and a one-factor at the school level. The PESOC’s convergent validity was supported by the school-level correlations between PESOC and another established instrument (i.e., the Team Climate Inventory). Further validation studies of PESOC are needed with larger, more representative samples, and with information on important outcomes such as student achievement and wellbeing.
|
|
| 6. |
- Högbom, Martin, et al.
(författare)
-
Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP
- 2007
-
Ingår i: Journal of Molecular Biology. - : Elsevier BV. - 0022-2836 .- 1089-8638. ; 372:1, s. 150-159
-
Tidskriftsartikel (refereegranskat)abstract
- DExD-box helicases are involved in all aspects of cellular RNA metabolism. Conserved domains 1 and 2 contain nine signature motifs that are responsible for nucleotide binding, RNA binding and ATP hydrolysis. The human DEAD-box helicase DDX3X has been associated with several different cellular processes, such as cell-growth control, mRNA transport and translation, and is suggested to be essential for the export of unspliced/partially spliced HIV mRNAs from the nucleus to the cytoplasm. Here, the crystal structure of conserved domains 1 and 2 of DDX3X, including a DDX3-specific insertion that is not generally found in human DExD-box helicases, is presented. The N-terminal domain 1 and the C-terminal domain 2 both display RecA-like folds comprising a central β-sheet flanked by α-helices. Interestingly, the DDX3X-specific insertion forms a helical element that extends a highly positively charged sequence in a loop, thus increasing the RNA-binding surface of the protein. Surprisingly, although DDX3X was crystallized in the presence of a large excess of ADP or the slowly hydrolyzable ATP analogue ATPγS the contaminant AMP was seen in the structure. A fluorescent-based stability assay showed that the thermal stability of DDX3X was increased by the mononucleotide AMP but not by ADP or ATPγS, suggesting that DDX3X is stabilized by AMP and elucidating why AMP was found in the nucleotide-binding pocket.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Karlberg, L, et al.
(författare)
-
Global Freshwater Resources
- 2009
-
Ingår i: Fisheries, Sustainability and Development. - Stockholm : Royal Swedish Academy of Agriculture and Forestry. ; , s. 123-132, s. 123-132
-
Tidskriftsartikel (refereegranskat)
|
|
| 10. |
|
|
