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Sökning: WFRF:(Karlsson Jan) > Övrigt vetenskapligt/konstnärligt

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  • Franzén, Karin, 1958-, et al. (författare)
  • Validation of the Swedish version of the Incontinence Impact Questionnaire, IIQ-7 and the Urogenital Distress Inventory, UDI-6.
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Introduction and hypothesis:The purpose was to validate the Swedish versions of the Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6). Methods: We analyzed reliability, validity, and responsiveness in a clinical sample of 96 women with UI. Result:Test-retest reliability ranged from moderate to almost perfect. Cronbach’s alpha was 0.39 (UDI-6) and 0.83 (IIQ-7). Effect size calculation of change after treatment demonstrated good responsiveness. The effect size at 6 months was moderate in the SUI group and small in the UUI+MUI group. There was a moderate to strong correlation between UDI-6 and IIQ-7 and treatment satisfaction at 6, 12, and 24 months for both groups. ConclusionThe Swedish UDI-6 and IIQ-7 show good responsiveness and are easy to administer and fill out. UDI-6 did not produce the same solid psychometrical results as IIQ-7, but both scales can be of clinical importance and are recommended for clinical use.
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  • Karlsson, Martin, et al. (författare)
  • Rotor dynamical analysis of a hydroelectric generator for active power
  • 2006
  • Ingår i: Proceedings. - Singapore : Aqua-Media International.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Asymmetry of the magnetic field in a synchronous generator will induce a magnetic unbalance pull. In this paper, a hydropower rotor system is modelled and the influence of electro-mechanical forces due to different amounts of real power is analysed. The electromagnetic field is solved with the finite element method and coupled with mechanical system as a magnetic stiffness. The mechanical model of the generator consists of a four degree of freedom rigid disc connected to an elastic shaft supported by two bearings with linear properties. It has been found that the unbalance magnetic pull increases for a lover amount of real power leading to a decrease of natural frequencies and an increase of unbalance response. Since many hydropower units are used for both part and full load it becomes important to model the electro-mechanical interaction when developing new generators, in order to improve the mechanical design.
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  • Mathioudaki, Argyri, Ph.D student, 1986-, et al. (författare)
  • Replication and fine mapping of ankylosing spondylitis replicated loci in the Swedish population reveal different CCHCR1 protective haplotypes
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Background: The genetics of ankylosing spondylitis (AS) derives mainly from studies performed in large cohorts of British origin. However, within Europe, disease prevalence is higher in Sweden, and so we investigated the reproducibility of known AS susceptibility patterns in a homogeneous Swedish cohort.Methods: The replication power of the Swedish cohort was examined and a set of published SNP associations intersected with genotypes from an existing targeted sequencing study using these individuals (381 controls; 310 AS cases). To elucidate whether replication patterns derived from population subsampling or genetic similarity, allele frequency data from additional British and Swedish control populations were examined for genetic differentiation (FST). Replicated loci were fine mapped to investigate associations in more detail, and signals were dissected with haplotype analysis and functional annotation.Results: The study had 80% power to find variants of strong effect (Odds ratio, OR>2) given a wide range of risk allele frequencies (0.2-3), tagging HLA-B,CCHCR1and IL23R. The replication pattern was not due to European population genetic distance and fine mapping revealed genome-wide repositioned associations in HLA-Band CCHCR1, independent from the published associations (p-value < 2 x10-8, r2 < 0.3). The CCHCR1 locus showed two protective haplotype blocks (B1-1 and B2-1), independent from HLA-B signals (B1-1: r2 = 0.39, B2-2:r2=0.07), where 74% of controls were carrying 2 copies of the protective haplotypes (B1-1 and B2-1: OR=0.3, p-value = 1.2 x 10-45). Interestingly, while both haplotypes span CCHCR1, the effect of each haplotype is likely in cis, with eQTL evidence pointing to the regulation of TCF19(B1-1) and POU5F1(B1-2).Conclusions: Both European populations share key disease loci, but the Swedish cohort revealed fine-scale genetic differences, that may point to gene regulation. This study utilized a different variant resolution, and by doing so demonstrated that smaller populations have the potential to reveal new AS pathogenesis mechanisms and that further study of the Swedish population is warranted.
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