| 1. |
- Nordanstig, Annika, 1974, et al.
(författare)
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EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry.
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.
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| 2. |
- Bergman, Annika, et al.
(författare)
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No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.
- 2008
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Ingår i: BMC Medical Genetics. - : BioMed Central. - 1471-2350. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The scaffold attachment factor B1 and B2 genes, SAFB1/SAFB2 (both located on chromosome 19p13.3) have recently been suggested as tumour suppressor genes involved in breast cancer development. The assumption was based on functional properties of the two genes and loss of heterozygosity of intragenic markers in breast tumours further strengthened the postulated hypothesis. In addition, linkage studies in Swedish breast cancer families also indicate the presence of a susceptibility gene for breast cancer at the 19p locus. Somatic mutations in SAFB1/SAFB2 have been detected in breast tumours, but to our knowledge no studies on germline mutations have been reported. In this study we investigated the possible involvement of SAFB1/SAFB2 on familiar breast cancer by inherited mutations in either of the two genes.RESULTS: Mutation analysis in families showing linkage to the SAFB1/2 locus was performed by DNA sequencing. The complete coding sequence of the two genes SAFB1 and SAFB2 was analyzed in germline DNA from 31 affected women. No missense or frameshift mutations were detected. One polymorphism was found in SAFB1 and eight polymorphisms were detected in SAFB2. MLPA-anlysis showed that both alleles of the two genes were preserved which excludes gene inactivation by large deletions.CONCLUSION: SAFB1 and SAFB2 are not likely to be causative of the hereditary breast cancer syndrome in west Swedish breast cancer families.
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| 3. |
- Bryllert, Tomas, 1974, et al.
(författare)
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220-GHz imaging radar with 1 Hz frame rate using an array of homodyne transceivers
- 2018
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10634
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Konferensbidrag (refereegranskat)abstract
- We present a 220 GHz imaging radar prototype that has been developed in the European Defense Agency (EDA) project TIPPSI. The purpose of the development was to demonstrate short-range high-resolution 3D imaging for security applications at checkpoints, and to guide the development of stand-off real-time millimeter wave and sub-millimeter wave imaging systems for detection of larger objects at greater distances. An additional goal was to experimentally verify simulation techniques for active (sub)-mmw imaging systems, the verified simulation techniques can then be used to explore different system architectures. The 220 GHz imaging radar prototype consist of a flexible, mechanically scanned optical system that can support linear arrays of transmit/receive (TxRx) units up to 150 mm in length. The optical system is divided into two parts: A compact Dragonian system including the mechanical scanner that can be used as a stand-alone imager at reduced target distance and resolution, and a confocal system that can be added to achieve the full resolution of 1 cm x 1 cm x 1 cm at 4.5 m target distance. The field of view of the full resolution system is 70 cm x 70 cm. The front-end is currently populated by 4 TxRx units that are sparsely distributed along the 150 mm focal plane. The TxRx units operate in frequency modulated continuous wave (FMCW) mode and have a bandwidth of 24 GHz. Each TxRx unit use a single horn antenna and the transmit- and receive signals are generated and received using the same circuits which avoids the need of a duplexer. We will demonstrate high resolution 3D videos taken at 1 Hz frame rate and compare the individual images with simulations using electromagnetic simulators and character/clothes animation.
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| 4. |
- Byström, Pär, 1974-, et al.
(författare)
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Warming decrease fish population densities and biomass
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Temperature impact all biota and ecosystems through its direct effect on the vital rates of primary producers and consumers. Still, how these changes in rates translates through ecosystem feed backs to the population level of top consumers are poorly understood. Here, we studied effects of temperature increase (+ 3 ̊C during ice free season) on fish population dynamics in a replicated large scale pond ecosystem experiment over 3 years. Increased temperature had no significant effect on whole ecosystem gross primary production while top down effects of warming on intermediate consumers changed from negative to positive due to negative effects of warming on fish population abundance. Total fish density and biomass and abundance of both mature and old fish decreased with warming, while proportion of young fish increased, with warming. The effects of warming on fish population demographics were likely due to that temperature increased cohort competition and fish energy requirements relative to resource production. Our results suggest that global warming may increase competition, favor young individuals and overall decrease fish population densities and biomass.
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| 5. |
- Hedström, Per, 1974-, et al.
(författare)
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Brownification increases winter mortality in fish
- 2017
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Ingår i: Oecologia. - : Springer Science and Business Media LLC. - 0029-8549 .- 1432-1939. ; 183:2, s. 587-595
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Tidskriftsartikel (refereegranskat)abstract
- In northernclimateswinter is a bottleneck for many organisms. Low light and resource availability constrain individual foraging rates,potentially leading tostarvation and increasedmortality.Increasinginput of humic substances to aquatic ecosystems causesbrownification of water and hence a further decreaseof light availability,which may lead tofurther decreased foraging ratesand starvation mortality during winter.To test this hypothesis, we measured the effectsof experimentally increased humicwaterinput on consumption and survival of young-of-the-year (YOY) three-spined stickleback (Gasterosteus aculeatus) over winterin largeoutdoor enclosures. Population densitieswereestimated in autumn andthefollowing springand food availabilityand consumptionwere monitoredoverwinter. As hypothesized,mortality washigher underhumic(76%)as compared to ambientconditions (64%).Also, body condition and ingested prey biomass werelower under humic conditionseven thoughresource availability wasnotlower under humic conditions. Light conditions were significantly poorer under humic conditions. This suggeststhat increased mortality and decreased body condition and ingested prey biomasswasnot due to decreased resource availability but due todecreasedsearch efficiencyin this visual feeding consumer. Increased future brownification of aquatic systems may therefore negatively affect both recruitment and densities of fish.
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| 6. |
- Hedström, Per, 1974-, et al.
(författare)
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Population and size dependent responses in fish production to climate change
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Climate change is predicted to increase water temperatures and export of terrestrial dissolved matter (TDOM) to aquatic ecosystems with concomitant effects on ecosystem productivity and production of consumers at the top of the food web. Here we study how increased level of TDOM and temperature alone or in combination affect benthic and pelagic primary production and biomass production of fish in replicated large scale outdoor pond experiment. We increased temperature (+3 ̊C) and TDOM concentrations (×2.5) using natural high TDOM water from a small creek and used naturally reproducing three-spine sticklebacks (Gasterosteus aculeatus) populations as model fish species. Gross primary production (GPP) was similar to ambient control conditions in all treatments although increased TDOM concentrations deceased benthic but stimulated pelagic GPP, presumably as a result of decreased light availability and increased nutrient availability, respectively. The production of young-of-the-year (YOY), older, and total fish population were negatively affected by warming, whereas increased TDOM caused decreased YOY and total fish production. Effect of temperature on fish production were likely a result of increased metabolic cost in relation to resource production and intake rates whereas the negative effect of TDOM on fish production was likely a result of decreasing benthic resource production. However, the combined effect on fish production of warming and TDOM was only intermediate compared to individual treatments. Our study suggest climate change will lead to decreased fish production and that the effect may be most pronounced in clear systems dominated by benthic GPP .
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| 7. |
- Karlsson, Jan, 1974-, et al.
(författare)
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Ice-melt period dominates annual carbon dioxide evasion from clear-water Arctic lakes
- 2023
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Ingår i: Limnology and Oceanography Letters. - : John Wiley & Sons. - 2378-2242.
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Tidskriftsartikel (refereegranskat)abstract
- Current estimates of carbon dioxide (CO2) evasion from Arctic lakes are highly uncertain because few studies integrate seasonal variability, specifically evasion during spring ice-melt. We quantified annual CO2 evasion for 14 clear-water Arctic lakes in Northern Sweden through mass balance (ice-melt period) and high-frequency loggers (open-water period). On average, 80% (SD: ± 18) of annual CO2 evasion occurred within 10 d following ice-melt. The contribution of the ice-melt period to annual CO2 evasion was high compared to earlier studies of Arctic lakes (47% ± 32%). Across all lakes, the proportion of ice-melt : annual CO2 evasion was negatively related to the dissolved organic carbon concentration and positively related to the mean depth of the lakes. The results emphasize the need for measurements of CO2 exchange at ice-melt to accurately quantify CO2 evasion from Arctic lakes.
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| 8. |
- Larsson, Alice, et al.
(författare)
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Do patients with large vessel occlusion ischemic stroke harboring prestroke disability benefit from thrombectomy?
- 2020
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Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 267
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Evidence of endovascular treatment (EVT) for acute large vessel occlusion (LVO) ischemic stroke in patients harboring substantial prestroke disability is lacking due to their exclusion from randomized trials. Here, we used routine care observational data to compare outcomes in patients with and without prestroke disability receiving EVT for LVO ischemic stroke. Methods: Consecutive patients undergoing EVT for acute LVO ischemic stroke at the Sahlgrenska University Hospital from January 1st, 2015 to March 31st, 2018 were registered in the Sahlgrenska Stroke Recanalization Registry. Pre- and poststroke functional levels were assessed by the modified Rankin Scale (mRS). Outcomes were recanalization rate (mTICI = 2b/3), symptomatic intracranial hemorrhage [sICH], complications during hospital stay, and return to prestroke functional level and mortality at 3 months. Results: Among 591 patients, 90 had prestroke disability (mRS ≥ 3). The latter group were older, more often female, had more comorbidities and higher NIHSS scores before intervention compared to patients without prestroke disability. Recanalization rates (80.0% vs 85.0%, p = 0.211), sICH (2.2% vs 6.3% p = 0.086) and the proportion of patients returning to prestroke functional level (22.7% vs 14.8% p = 0.062) did not significantly differ between those with and without prestroke disability. Patients with prestroke disability had higher complication rates during hospital stay (55.2% vs 40.1% p < 0.01) and mortality at 3 months (48.9% vs 24.3% p < 0.001). Conclusion: One of five with prestroke disability treated with thrombectomy for a LVO ischemic stroke returned to their prestroke functional level. However, compared to patients without prestroke disability, mortality at 3 months was higher. © 2020, The Author(s).
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| 9. |
- Pascual, Didac, et al.
(författare)
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The missing pieces for better future predictions in subarctic ecosystems: A Torneträsk case study
- 2021
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Ingår i: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 50:2, s. 375-392
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Forskningsöversikt (refereegranskat)abstract
- Arctic and subarctic ecosystems are experiencing substantial changes in hydrology, vegetation, permafrost conditions, and carbon cycling, in response to climatic change and other anthropogenic drivers, and these changes are likely to continue over this century. The total magnitude of these changes results from multiple interactions among these drivers. Field measurements can address the overall responses to different changing drivers, but are less capable of quantifying the interactions among them. Currently, a comprehensive assessment of the drivers of ecosystem changes, and the magnitude of their direct and indirect impacts on subarctic ecosystems, is missing. The Torneträsk area, in the Swedish subarctic, has an unrivalled history of environmental observation over 100 years, and is one of the most studied sites in the Arctic. In this study, we summarize and rank the drivers of ecosystem change in the Torneträsk area, and propose research priorities identified, by expert assessment, to improve predictions of ecosystem changes. The research priorities identified include understanding impacts on ecosystems brought on by altered frequency and intensity of winter warming events, evapotranspiration rates, rainfall, duration of snow cover and lake-ice, changed soil moisture, and droughts. This case study can help us understand the ongoing ecosystem changes occurring in the Torneträsk area, and contribute to improve predictions of future ecosystem changes at a larger scale. This understanding will provide the basis for the future mitigation and adaptation plans needed in a changing climate.
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| 10. |
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