| 1. |
- Andersson, Niklas, 1970, et al.
(författare)
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Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men
- 2009
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 33:5, s. 525-533
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Tidskriftsartikel (refereegranskat)abstract
- Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteoporosis and obesity determinants (GOOD) study is a population-based cross-sectional study of 18-20 year-old men (n = 1068), from Gothenburg, Sweden. Major findings were confirmed in elderly men (n = 3014) from the Swedish part of the osteoporotic fractures in men (MrOS) multicenter population-based study. Main Outcome Measure: The genotype distributions and their association with body fat mass in different compartments, measured with dual-energy X-ray absorptiometry (DXA). Results: Out of 15 investigated SNPs in the IL-1 receptor antagonist (IL1RN) gene, a recently identified 30 untranslated region C4T (rs4252041, minor allele frequency 4%) SNP was associated with the primary outcome total fat mass (P = 0.003) and regional fat masses, but not with lean body mass or serum IL-1 receptor 1 (IL1RN) levels. This SNP was also associated with body fat when correcting the earlier reported IL1RN_2018 T4C (rs419598) SNP (in linkage disequilibrium with a well-studied variable number tandem repeat of 86 bp). The association between rs4252041 SNP and body fat was confirmed in the older MrOS population (P = 0.03). The rs4252041 SNP was part of three haplotypes consisting of five adjacent SNPs that were identified by a sliding window approach. These haplotypes had a highly significant global association with total body fat (P < 0.001). None of the other investigated members of the IL-1 gene family displayed any SNPs that have not been described previously to be significantly associated with body fat. Conclusions: The IL1RN gene, shown to enhance obesity by suppressing IL-1 effects in experimental animals, have no previously described gene polymorphisms and haplotypes that are associated with fat, but not lean mass in two populations of men. International Journal of Obesity (2009) 33, 525-533; doi: 10.1038/ijo.2009.47; published online 17 March 2009
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| 2. |
- Björk, Magnus, 1977, et al.
(författare)
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Exposed Datapath for Efficient Computing
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We introduce FlexCore, which is the first exemplar of a processor based on the FlexSoC processor paradigm. TheFlexCore utilizes an exposed datapath for increased performance. Microbenchmarks yield a performance boost of a factor of two over a traditional five-stage pipeline with the same functional units as the FlexCore.We describe our approach to compiling for the FlexCore.A flexible interconnect allows the FlexCore datapath to bedynamically reconfigured as a consequence of code generation. Additionally, specialized functional units may be introduced and utilized within the same architecture and compilation framework. The exposed datapath requires a wide control word. The conducted evaluation of two micro benchmarks confirms that this increases the instruction bandwidth and memory footprint. This calls for an efficient instruction decoding as proposed in the FlexSoC paradigm.
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| 4. |
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| 5. |
- Mazur, Mikael, 1990, et al.
(författare)
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Field Trial of FPGA-Based Real-Time Sensing Transceiver over 524km of Live Aerial Fiber
- 2023
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Ingår i: Optical Fiber Communication Conference, OFC 2023. - 9781957171180
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Konferensbidrag (refereegranskat)abstract
- We perform fiber sensing over a 524 km live network using a real-time coherent transceiver prototype. Polarization and length changes from the link consisting exclusively of aerial fiber wound around high-voltage power cables are continuously monitored.
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| 6. |
- Mazur, Mikael, 1990, et al.
(författare)
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Real-Time Monitoring of Cable Break in a Live Network using a Coherent Transceiver Prototype
- 2024
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Ingår i: Optical Fiber Communication Conference, OFC 2024. - 9781957171326
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Konferensbidrag (refereegranskat)abstract
- We monitor a 524-km live network link using an real-time FPGA-based sensing-capable transceiver prototype during a human-caused cable break. Polarization sensing data shows minute-level potential break warning precursors, offering outage mitigation prospects.
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| 7. |
- Agrell, Erik, 1965, et al.
(författare)
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Capacity of a nonlinear optical channel with finite memory
- 2014
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 32:16, s. 2862-2876
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Tidskriftsartikel (refereegranskat)abstract
- The channel capacity of a nonlinear, dispersive fiber-optic link is revisited. To this end, the popular Gaussian noise (GN) model is extended with a parameter to account for the finite memory of realistic fiber channels. This finite-memory model is harder to analyze mathematically but, in contrast to previous models, it is valid also for nonstationary or heavy-tailed input signals. For uncoded transmission and standard modulation formats, the new model gives the same results as the regular GN model when the memory of the channel is about ten symbols or more. These results confirm previous results that the GN model is accurate for uncoded transmission. However, when coding is considered, the results obtained using the finite-memory model are very different from those obtained by previous models, even when the channel memory is large. In particular, the peaky behavior of the channel capacity, which has been reported for numerous nonlinear channel models, appears to be an artifact of applying models derived for independent input in a coded (i.e., dependent) scenario. © 1983-2012 IEEE.
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| 8. |
- Agrell, Erik, 1965, et al.
(författare)
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Influence of Behavioral Models on Multiuser Channel Capacity
- 2015
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 33:17, s. 3507-3515
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Tidskriftsartikel (refereegranskat)abstract
- In order to characterize the channel capacity of a wavelength channel in a wavelength-division multiplexed (WDM) system, statistical models are needed for the transmitted signals on the other wavelengths. For example, one could assume that the transmitters for all wavelengths are configured independently of each other, that they use the same signal power, or that they use the same modulation format. In this paper, it is shown that these so-called behavioral models have a profound impact on the single-wavelength achievable information rate. This is demonstrated by establishing, for the first time, upper and lower bounds on the maximum achievable rate under various behavioral models, for a rudimentary WDM channel model.
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| 9. |
- Agrell, Erik, 1965, et al.
(författare)
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Modulation and detection for multicore superchannels with correlated phase noise [Invited]
- 2018
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Ingår i: 2018 Conference on Lasers and Electro-Optics, CLEO 2018 - Proceedings. ; Part F94-CLEO_SI 2018
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Konferensbidrag (refereegranskat)abstract
- SDM fibers offer new opportunities and challenges for joint transmitter and receiver processing. We review multidimensional modulation and detection theory, describe algorithms for phase tracking and detection over spatial superchannels, and present some experimental results.
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| 10. |
- Agrell, Erik, 1965, et al.
(författare)
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On the symbol error probability of regular polytopes
- 2011
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Ingår i: IEEE Transactions on Information Theory. - 0018-9448 .- 1557-9654. ; 57:6, s. 3411-3415
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Tidskriftsartikel (refereegranskat)abstract
- An exact expression is derived for the symbol error probability when the vertices of the four-dimensional 24-cell are used for digital transmission in Gaussian noise. Corresponding expressions for other regular convex polytopes are summarized. Numerically stable versions of these error probabilities are also obtained. © 2011 IEEE.
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