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Träfflista för sökning "WFRF:(Karlsson Magnus 1967 ) ;lar1:(oru)"

Sökning: WFRF:(Karlsson Magnus 1967 ) > Örebro universitet

  • Resultat 1-7 av 7
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1.
  • Alijagic, Andi, 1992-, et al. (författare)
  • Particle Safety Assessment in Additive Manufacturing : From Exposure Risks to Advanced Toxicology Testing.
  • 2022
  • Ingår i: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 4
  • Tidskriftsartikel (refereegranskat)abstract
    • Additive manufacturing (AM) or industrial three-dimensional (3D) printing drives a new spectrum of design and production possibilities; pushing the boundaries both in the application by production of sophisticated products as well as the development of next-generation materials. AM technologies apply a diversity of feedstocks, including plastic, metallic, and ceramic particle powders with distinct size, shape, and surface chemistry. In addition, powders are often reused, which may change the particles' physicochemical properties and by that alter their toxic potential. The AM production technology commonly relies on a laser or electron beam to selectively melt or sinter particle powders. Large energy input on feedstock powders generates several byproducts, including varying amounts of virgin microparticles, nanoparticles, spatter, and volatile chemicals that are emitted in the working environment; throughout the production and processing phases. The micro and nanoscale size may enable particles to interact with and to cross biological barriers, which could, in turn, give rise to unexpected adverse outcomes, including inflammation, oxidative stress, activation of signaling pathways, genotoxicity, and carcinogenicity. Another important aspect of AM-associated risks is emission/leakage of mono- and oligomers due to polymer breakdown and high temperature transformation of chemicals from polymeric particles, both during production, use, and in vivo, including in target cells. These chemicals are potential inducers of direct toxicity, genotoxicity, and endocrine disruption. Nevertheless, understanding whether AM particle powders and their byproducts may exert adverse effects in humans is largely lacking and urges comprehensive safety assessment across the entire AM lifecycle-spanning from virgin and reused to airborne particles. Therefore, this review will detail: 1) brief overview of the AM feedstock powders, impact of reuse on particle physicochemical properties, main exposure pathways and protective measures in AM industry, 2) role of particle biological identity and key toxicological endpoints in the particle safety assessment, and 3) next-generation toxicology approaches in nanosafety for safety assessment in AM. Altogether, the proposed testing approach will enable a deeper understanding of existing and emerging particle and chemical safety challenges and provide a strategy for the development of cutting-edge methodologies for hazard identification and risk assessment in the AM industry.
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2.
  • Alijagic, Andi, 1992-, et al. (författare)
  • A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles
  • 2023
  • Ingår i: Cells. - : MDPI. - 2073-4409. ; 12:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and materials to produce a variety of complex products. However, the effects of the unintentionally emitted AM (nano)particles (AMPs) on human cells following inhalation, require further investigations. The physicochemical characterization of the AMPs, extracted from the filter of a Laser Powder Bed Fusion (L-PBF) 3D printer of iron-based materials, disclosed their complexity, in terms of size, shape, and chemistry. Cell Painting, a high-content screening (HCS) assay, was used to detect the subtle morphological changes elicited by the AMPs at the single cell resolution. The profiling of the cell morphological phenotypes, disclosed prominent concentration-dependent effects on the cytoskeleton, mitochondria, and the membranous structures of the cell. Furthermore, lipidomics confirmed that the AMPs induced the extensive membrane remodeling in the lung epithelial and macrophage co-culture cell model. To further elucidate the biological mechanisms of action, the targeted metabolomics unveiled several inflammation-related metabolites regulating the cell response to the AMP exposure. Overall, the AMP exposure led to the internalization, oxidative stress, cytoskeleton disruption, mitochondrial activation, membrane remodeling, and metabolic reprogramming of the lung epithelial cells and macrophages. We propose the approach of integrating Cell Painting with metabolomics and lipidomics, as an advanced nanosafety methodology, increasing the ability to capture the cellular and molecular phenotypes and the relevant biological mechanisms to the (nano)particle exposure.
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3.
  • Alijagic, Andi, 1992-, et al. (författare)
  • Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals
  • 2024
  • Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 183
  • Tidskriftsartikel (refereegranskat)abstract
    • Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing or additive manufacturing (AM). Powder-based AM technologies employ tonnes of polyamide microplastics to produce complex components every year. However, the lack of comprehensive toxicity assessment of particulate polyamides and polyamide-associated chemicals, especially in the light of the global microplastics crisis, calls for urgent action. This study investigated the physicochemical properties of polyamide-12 microplastics used in AM, and assessed a number of toxicity endpoints focusing on inflammation, immunometabolism, genotoxicity, aryl hydrocarbon receptor (AhR) activation, endocrine disruption, and cell morphology. Specifically, microplastics examination by means of field emission scanning electron microscopy revealed that work flow reuse of material created a fraction of smaller particles with an average size of 1-5 µm, a size range readily available for uptake by human cells. Moreover, chemical analysis by means of gas chromatography high-resolution mass spectrometry detected several polyamide-associated chemicals including starting material, plasticizer, thermal stabilizer/antioxidant, and migrating slip additive. Even if polyamide particles and chemicals did not induce an acute inflammatory response, repeated and prolonged exposure of human primary macrophages disclosed a steady increase in the levels of proinflammatory chemokine Interleukin-8 (IL-8/CXCL-8). Moreover, targeted metabolomics disclosed that polyamide particles modulated the kynurenine pathway and some of its key metabolites. The p53-responsive luciferase reporter gene assay showed that particles per se were able to activate p53, being indicative of a genotoxic stress. Polyamide-associated chemicals triggered moderate activation of AhR and elicited anti-androgenic activity. Finally, a high-throughput and non-targeted morphological profiling by Cell Painting assay outlined major sites of bioactivity of polyamide-associated chemicals and indicated putative mechanisms of toxicity in the cells. These findings reveal that the increasing use of polyamide microplastics may pose a potential health risk for the exposed individuals, and it merits more attention.
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5.
  • Karlsson, Fredrik, 1974-, et al. (författare)
  • Attempts to share information between public sector organisations over time : A case-based exploration of value conflicts
  • 2021
  • Ingår i: Information Polity. - : IOS Press. - 1570-1255 .- 1875-8754. ; 26:3, s. 289-310
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite the importance of inter-organisational information sharing (IOIS) in the public sector, such endeavours often fail. Existing research has shown that the values held by collaborating organisations are one important factor affecting these kinds of initiatives. However, research has sought only to a limited extent to address how value conflicts come into play over time. Therefore, this paper aims to explore how conflicting values shape an inter-organisational information-sharing practice in the public sector over time. Using the local/global network framework, we analyse four years’ worth of information sharing in an inter-organisational advisory group in the context of Swedish nuclear waste management. We conclude that different value conflicts are emphasised to different extents at different points in time. That is, values do not uniformly affect IOIS activities, and such conflicts over time reduce the set of potential IOIS activities. We also conclude that when IOIS activities are driven by an individual organisation’s values, individual value rational activities may co-exist with a dysfunctional long-term IOIS practice.
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6.
  • Karlsson, Fredrik, 1974-, et al. (författare)
  • Inter-organisational information sharing : Between a rock and a hard place
  • 2015
  • Ingår i: Proceedings of the Ninth International Symposium on Human Aspects of Information  Security & Assurance (HAISA 2015). - Plymouth UK : Plymouth University. - 9781841023885 ; , s. 71-81
  • Konferensbidrag (refereegranskat)abstract
    • Although inter-organisational collaboration is common, most information security (IS) research has focused on IS issues within organisations. Confidentiality, integrity of data and availability (CIA) and responsibility, integrity of role, trust, and ethicality (RITE) are two sets of principles for managing IS that have been developed from an intra-organisational, rather static, perspective. The aim of this paper is thus to investigate the relation between the CIA and RITE principles in the context of an inter-organisational collaboration, i.e., collaboration between organisations. To this end we investigated inter-organisational collaboration and information sharing concerning Swedish cooper corrosion research in the field a long-term nuclear waste disposal. We found that in an inter-organisational context, responsibility, integrity of role and ethicality affected the CIA-principles, which in turn affected the collaborating actors’ trust in each other over time.
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7.
  • Kellgren, Jan, 1967-, et al. (författare)
  • Funktionsförsäljning : en juridisk översikt och några råd för dig som överväger att börja sälja eller köpa funktion
  • 2019
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Denna populärvetenskapliga guide till juridiken kring funktionsförsäljning (eller, om man så vill, as a service-försäljning) avser att ge dels en översiktlig bild av rättsläget för funktionsförsäljning, dels några goda råd, ur ett i första hand juridiskt perspektiv, för dig som överväger att börja sälja eller köpa funktion. Guiden är skriven med en tänkt målgrupp i sikte, nämligen i första hand företagsledningar som inte har någon egen större avdelning för redovisning och juridik. Vi tror och hoppas dock att den ska visa sig vara användbar för bredare grupper.Här kommer vi också att lägga upp, stegvis förnyade, länkar till vetenskapliga publikationer om juridiken kring funktionsförsäljning (flera är under publicering). Kanske finner du också, med tiden, nya upplagor av denna guide här. Läge för ett bokmärke alltså…Guiden har skrivits av en grupp forskare som under flera år har forskat på juridiken kring funktionsförsäljning. Forskningen har i första hand finansierats av Energimyndigheten (och i nära samarbete med forskningsorganisationen Mistra REES), men vi har också arbetat för näringslivet med dessa frågor.
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  • Resultat 1-7 av 7
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