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No breast cancer su...
No breast cancer subgroup can be spared postoperative radiotherapy after breast-conserving surgery. Fifteen-year results from the Swedish Breast Cancer Group randomised trial, SweBCG 91 RT
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- Killander, F. (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Oncol, Lund, Sweden.;Skane Univ Hosp, Skane Dept Oncol, Lund, Sweden.
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- Karlsson, Per, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens Univ Hosp, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.
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- Anderson, H. (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept Clin Sci, Canc Epidemiol, Lund, Sweden.
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- Mattsson, J. (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Sweden.
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- Holmberg, E. (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Reg Oncol Ctr, Gothenburg, Sweden.
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- Lundstedt, Dan, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens Univ Hosp, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Univ Uppsala Hosp, Reg Oncol Ctr, Uppsala, Sweden.;Kings Coll London, Fac Life Sci & Med, Div Canc Studies, London, England.
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- Malmström, P. (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund,Skåne University Hospital,Lund Univ, Dept Clin Sci, Oncol, Lund, Sweden.;Skane Univ Hosp, Skane Dept Oncol, Lund, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 9 s.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 67, s. 57-65
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Breast-conserving surgery (BCS) followed by radiotherapy (RT) is an established treatment for women with T1-2N0 breast cancers. Since subgroups of patients have low ipsilateral breast tumour recurrence (IBTR) rates, it is important to study whether RT is necessary for all patients. Patients and methods A total of 1187 women with primary T1-2N0M0 breast cancer were randomised, after standardised sector resection, to postoperative whole breast RT or no local treatment. Adjuvant systemic therapy was offered to patients with stage II cancers. Patients were followed with clinical examinations and annual mammography for 10 years and thereafter referred to the Swedish mammography screening program. Results After 15 years of follow-up, a higher cumulative incidence of IBTR was observed in control patients, 23.9%, versus irradiated patients, 11.5%, P < 0.001. Recurrence-free survival was inferior, 51.7% versus 60.4%, P = 0.0013. The main effect of RT was seen during the first 5 years. However, overall survival was not significantly lower 68.4% versus 71.1%, P = 0.68, nor was breast cancer–specific mortality significantly higher. Conclusions RT after BCS significantly reduced the incidence of IBTR at 15 years of follow-up. We were unable to identify subgroups which could be spared RT. Breast cancer mortality was not significantly reduced after RT. Good predictive markers for radiation sensitivity and improved adjuvant systemic therapy are needed to omit RT after BCS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Breast-conserving surgery
- Contralateral breast cancer
- Ipsilateral breast tumour recurrence
- Randomised trial
- Whole breast radiation
- breast cancer
- radiotherapy
- Breast cancer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Killander, F.
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Karlsson, Per, 1 ...
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Anderson, H.
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Mattsson, J.
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Holmberg, E.
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Lundstedt, Dan, ...
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Holmberg, Lars
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Malmström, P.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Cancer och onkol ...
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European Journal ...
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Lunds universitet
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Göteborgs universitet
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