| 1. |
- Wang, Yunzhang, et al.
(författare)
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Comprehensive longitudinal study of epigenetic mutations in aging
- 2019
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Ingår i: Clinical Epigenetics. - : BioMed Central. - 1868-7083 .- 1868-7075. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Background: The role of DNA methylation in aging has been widely studied. However, epigenetic mutations, here defined as aberrant methylation levels compared to the distribution in a population, are less understood. Hence, we investigated longitudinal accumulation of epigenetic mutations, using 994 blood samples collected at up to five time points from 375 individuals in old ages.Results: We verified earlier cross-sectional evidence on the increase of epigenetic mutations with age, and identified important contributing factors including sex, CD19+ B cells, genetic background, cancer diagnosis, and technical artifacts. We further classified epigenetic mutations into High/Low Methylation Outliers (HMO/LMO) according to their changes in methylation, and specifically studied methylation sites (CpGs) that were prone to mutate (frequently mutated CpGs). We validated four epigenetically mutated CpGs using pyrosequencing in 93 samples. Furthermore, by using twins, we concluded that the age-related accumulation of epigenetic mutations was not related to genetic factors, hence driven by stochastic or environmental effects.Conclusions: Here we conducted a comprehensive study of epigenetic mutation and highlighted its important role in aging process and cancer development.
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| 2. |
- Gunnarsson, Robert, 1972-, et al.
(författare)
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Brackets and the structure sense
- 2014
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Ingår i: Development of Mathematics Teaching: Design, Scale, Effects. - Linköping : Svensk förening för MatematikDidaktisk Forskning - SMDF. - 9789197393492 ; , s. 47-55
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Konferensbidrag (refereegranskat)abstract
- Brackets are essential structure elements in mathematics expressions. However, students have shown to have scattered understanding of the concept of brackets and how they are used in mathematical expressions. In this paper we present data that illustrate students’ perceptions of the word “brackets” and how these perceptions influence their use of brackets in numerical expressions. Based on our data we argue that the teaching of the concept of brackets also need to describe brackets as ordered pairs where each symbol has a unique counterpart and that insertion of brackets can, but does not have to, modify the structure of an expression.
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| 3. |
- Karlsson, Annasara, et al.
(författare)
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Students' perceptions of brackets
- 2013
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Ingår i: Proceedings of the 37th Conference of the International Group for the Psychology of Mathematics Education, vol. 5. - Kiel, Germany : IGPME. ; , s. 85-
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Konferensbidrag (refereegranskat)
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| 4. |
- Karlsson, Charlie, 1945-, et al.
(författare)
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Media Clusters: What Makes Them Unique?
- 2011
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Ingår i: Media Clusters. - Cheltenham : Edward Elgar Publishing. - 9780857932686 ; , s. 3-29
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Bokkapitel (refereegranskat)
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| 5. |
- Karlsson, Charlie, 1945-, et al.
(författare)
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The Challenges of Media Clusters
- 2011
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Ingår i: Media Clusters. - Cheltenham : Edward Elgar Publishing. - 9780857932686 ; , s. 379-395
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Bokkapitel (refereegranskat)
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| 6. |
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