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Sökning: WFRF:(Karlsson Torbjorn)

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1.
  • Westerberg, Per-Anton, et al. (författare)
  • Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs).
  • 2013
  • Ingår i: BMC nephrology. - 1471-2369. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Fibroblast growth factor 23 (FGF23) is the earliest marker of disturbed mineral metabolism as renal function decreases. Its serum levels are associated with mortality in dialysis patients, persons with chronic kidney disease (CKD) and prevalent cardiovascular disease (CVD), and it is associated with atherosclerosis, endothelial dysfunction and left ventricular hypertrophy in the general population. The primary aim of this study is to examine the association between FGF23 and mortality, in relation to renal function in the community. A secondary aim is to examine the association between FGF23 and CVD related death. Methods: The population-based cohort of MrOS Sweden included 3014 men (age 69-81 years). At inclusion intact FGF23, intact parathyroid hormone (PTH), 25 hydroxyl vitamin D (25D), calcium and phosphate were measured. Mortality data were collected after an average of 4.5 years follow-up. 352 deaths occurred, 132 of CVD. Association between FGF23 and mortality was analyzed in quartiles of FGF23. Kaplan-Meier curves and Log-rank test were used to examine time to events. Cox proportional hazards regression was used to examine the association between FGF23, in quartiles and as a continuous variable, with mortality. The associations were also analyzed in the sub-cohort with estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73 m(2). Results: There was no association between FGF23 and all-cause mortality, Hazard ratio (HR) 95% confidence interval (CI): 1.02 (0.89-1.17). For CVD death the HR (95% CI) was 1.26 (0.99 - 1.59)/(1-SD) increase in log(10) FGF23 after adjustment for eGFR, and other confounders. In the sub-cohort with eGFR > 60 ml/min/1.73 m(2) the HR (95% CI) for CVD death was 55% (13-111)/(1-SD) increase in log(10) FGF23. Conclusions: FGF23 is not associated with mortality of all-cause in elderly community living men, but there is a weak association with CVD death, even after adjustment for eGFR and the other confounders. The association with CVD death is noticeable only in the sub-cohort with preserved renal function.
2.
  • Ardern, Clare, et al. (författare)
  • 2018 International Olympic Committee consensus statement on prevention, diagnosis and management of paediatric anterior cruciate ligament (ACL) injuries
  • 2018
  • Ingår i: Knee Surgery, Sports Traumatology, Arthroscopy. - SPRINGER. - 0942-2056 .- 1433-7347. ; 26:4, s. 989-1010
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric anterior cruciate ligament (ACL) injuries. Representatives from the American Orthopaedic Society for Sports Medicine, European Paediatric Orthopaedic Society, European Society for Sports Traumatology, Knee Surgery and Arthroscopy, International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine, Pediatric Orthopaedic Society of North America, and Sociedad Latinoamericana de Artroscopia, Rodilla y Deporte attended. Physiotherapists and orthopaedic surgeons with clinical and research experience in the field, and an ethics expert with substantial experience in the area of sports injuries also participated. Injury management is challenging in the current landscape of clinical uncertainty and limited scientific knowledge. Injury management decisions also occur against the backdrop of the complexity of shared decision-making with children and the potential long-term ramifications of the injury. This consensus statement addresses six fundamental clinical questions regarding the prevention, diagnosis, and management of paediatric ACL injuries. The aim of this consensus statement is to provide a comprehensive, evidence-informed summary to support the clinician, and help children with ACL injury and their parents/guardians make the best possible decisions.</p>
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3.
  • Ardern, Clare, et al. (författare)
  • 2018 International Olympic Committee consensus statement on prevention, diagnosis and management of paediatric anterior cruciate ligament (ACL) injuries
  • 2018
  • Ingår i: British Journal of Sports Medicine. - BMJ PUBLISHING GROUP. - 0306-3674 .- 1473-0480. ; 52:7, s. 422-438
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric ACL injuries. Representatives from the American Orthopaedic Society for Sports Medicine, European Paediatric Orthopaedic Society, European Society for Sports Traumatology, Knee Surgery amp; Arthroscopy, International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine, Pediatric Orthopaedic Society of North America and Sociedad Latinoamericana de Artroscopia, Rodilla y Deporte attended. Physiotherapists and orthopaedic surgeons with clinical and research experience in the field, and an ethics expert with substantial experience in the area of sports injuries also participated. Injury management is challenging in the current landscape of clinical uncertainty and limited scientific knowledge. Injury management decisions also occur against the backdrop of the complexity of shared decision-making with children and the potential long-term ramifications of the injury. This consensus statement addresses six fundamental clinical questions regarding the prevention, diagnosis and management of paediatric ACL injuries. The aim of this consensus statement is to provide a comprehensive, evidence-informed summary to support the clinician, and help children with ACL injury and their parents/ guardians make the best possible decisions.</p>
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5.
  • Das, Biswanath, et al. (författare)
  • Water oxidation catalyzed by molecular di- and nonanuclear Fe complexes: importance of a proper ligand framework
  • 2016
  • Ingår i: Dalton Transactions. - ROYAL SOC CHEMISTRY. - 1477-9226 .- 1477-9234. ; 45:34, s. 13289-13293
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The synthesis of two molecular iron complexes, a dinuclear iron(III,III) complex and a nonanuclear iron complex, based on the di-nucleating ligand 2,2-(2-hydroxy-5-methyl-1,3-phenylene)bis(1H-benzo[d]imidazole-4-carboxylic acid) is described. The two iron complexes were found to drive the oxidation of water by the one-electron oxidant [Ru(bpy)(3)](3+).</p>
6.
  • Ekman, Petter, 1988-, et al. (författare)
  • Aerodynamic Drag Reduction of a Light Truck - from Conceptual Design to Full Scale Road Tests
  • 2016
  • Ingår i: SAE 2016 World Congress and Exhibition. - SAE International.
  • Konferensbidrag (refereegranskat)abstract
    • <p>Considerable amounts of the everyday goods transports are done using light trucks. In the last ten years (2005-2015), the number of light trucks has increased by 33 % in Sweden. The majority of these light trucks are fitted with a swap body and encounter the same problem as many other truck configurations, namely that several different manufacturers contribute to the final shape of the vehicle. Due to this, the aerodynamics of the final vehicle is often not fully considered. Hence there appears to be room for improving the aerodynamic performance. In this study the flow around a swap body fitted to a light truck has been investigated using Computational Fluid Dynamics. The focus has been on improving the shape of the swap body in order to reduce both the aerodynamic drag and fuel consumption, while still keeping it usable for daily operations. Reynolds-Averaged Navier-Stokes simulations were used for concept evaluation while more advanced Detached Eddy Simulations were performed on the best concept in order to investigate details of the flow. Various concepts were evaluated from which it could be seen that a more streamlined top of the swap body together with a lowered top trailing edge had a significant positive effect on the aerodynamic drag. A full scale light truck was equipped with a swap body with with these modifications for road tests. During a test period, a mean fuel consumption reduction of 12 % was measured, thus indicating a significantly reduced aerodynamic drag.</p>
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7.
  • Ekman, Petter, et al. (författare)
  • Aerodynamics of an Unloaded Timber Truck - A CFD Investigation
  • 2016
  • Ingår i: SAE International Journal of Commercial Vehicles. - SAE INT. - 1946-391X .- 1946-3928. ; 9:2, s. 217-223
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Reducing energy consumption and emissions are ongoing challenges for the transport sector. The increased number of goods transports emphasize these challenges even more, as greenhouse gas emissions from these vehicles increased by 20 % between 1990 and 2013, in Sweden. One special case of goods transports is the transport of timber. Today in Sweden, around 2000 timber trucks transport around six billion ton kilometers every year. For every ton kilometer these vehicles use around 0.025 liter diesel, and there should exist large possibilities to reduce the fuel consumption and the emissions for these vehicles. Timber trucks spend most of their operation time travelling in speeds of around 80 km/h. At this speed aerodynamic drag contributes to around 30 % of the total vehicle resistance, which makes the aerodynamic drag a significant part of the energy consumption. One of the big challenges with timber trucks is that they travel unloaded half of the time. This put higher demands on possible drag reduction modifications, as they need to function and be practical for both when the timber truck is loaded and unloaded. In this study an unloaded timber truck has been investigated by use of computational fluid dynamics. The recently released Stress Blended Eddy Simulation model has been used for simulating the flow over a timber truck at a Reynolds number of 1.1 million, based on the square root of its frontal area. From the results it could be seen that 52.8 % of the drag is generated by the cab. By investigating a drag reduction device that covered the gap between the bulkhead and the first stake pair, a drag reduction up to 6.7 % was possible, which shows potential for simple modifications that not influence the daily usage.</p>
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8.
  • Hagvall, Kristoffer, et al. (författare)
  • Speciation of aluminum in soils and stream waters: The importance of organic matter
  • 2015
  • Ingår i: Chemical Geology. - Elsevier. - 0009-2541. ; 417, s. 32-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Aluminum (Al) is the most common metal in the Earth's crust, and exists mainly in the form of silicates, oxides and hydroxides, or in complexes with natural organic matter (NOM) or inorganic ligands. Since speciation is a key factor for understanding the environmental impact of Al, it is important to determine the chemical forms of Al that predominate in different natural media and under varying geochemical conditions. This study investigated how complexation with NOM influenced the speciation of Al(III) in different environmental samples (isolated aquatic NOM, organic soils and stream waters) using X-ray absorption spectroscopy (XAS) and Infrared (IR) spectroscopy. The combined spectroscopic results showed that Al(III) formed mononuclear complexes with carboxylic functional groups in NOM that were sufficiently stable to suppress the hydrolysis and polymerization of Al(III). These organic Al complexes were favored at slightly acidic pH values between pH 3 and 6 and at decreasing Al concentrations. The XAS results of the organic soils and the stream water samples indicated a variation in the speciation from a predominance of organically complexed Al in the stream waters to a mixture of Al-NOM complexes and precipitated Al phases (Al hydroxides and/or Al silicates) in the organic soils. Although the presented XAS results were limited by relatively low signal-to-noise caused by the low K-edge energy of Al, the combined spectroscopic results provided new and useful information about Al in different environmental samples and showed that NOM and pH are important parameters controlling the speciation of Al. (C) 2015 Elsevier B.V. All rights reserved.
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9.
  • Hagvall, Kristoffer, et al. (författare)
  • Spectroscopic characterization of the coordination chemistry and hydrolysis of gallium(III) in the presence of aquatic organic matter
  • 2014
  • Ingår i: Geochimica et Cosmochimica Acta. - Elsevier. - 0016-7037. ; 146, s. 76-89
  • Tidskriftsartikel (refereegranskat)abstract
    • Interactions between metals and natural organic matter (NOM) are of great environmental importance and one of the key factors influencing hydrolysis, solubility, and speciation of the metals. However, studying geochemically relevant metals like Al, Fe, and Cu is sometimes associated with analytical problems; for example Fe and Cu are both redox active. Gallium (Ga) is a non-redox active metal that usually occurs at very low concentrations in environmental samples and therefore a wide concentration range of metal(III)-NOM species can be explored by adding Ga(III) to such samples. This makes Ga(III) a good probe and analogue for other metal ions, in particular Al. In addition, due to the increased usage of Ga in society, a better understanding of how Ga interacts with NOM is of importance but such studies are scarce. In this work, Ga(III) interactions with two different organic materials (Suwannee River natural organic matter and Suwannee River fulvic acid) were studied using infrared (IR) and extended X-ray absorption fine structure (EXAFS) spectroscopy in a large experimental range (101-84,076 mu g Ga g(-1) dry weight; pH 3-8). Our IR spectroscopic results showed that Ga(III) is bonded mainly to carboxylic functional groups and suggested that only a fraction of the total number of carboxylic sites in the samples was actively involved in the bonding. Modeling of the EXAFS data revealed that Ga(III) formed mononuclear chelate complexes with NOM that strongly suppressed the hydrolysis and polymerization of Ga(III). At low Ga(III) concentrations (1675-16,649 mu g g(-1)) organic complexes, consisting of 1-3 chelate ring structures, were the dominating species in the entire pH range while at higher concentrations (67,673-84,076 mu g g(-1), pH 3.0-7.0) we detected mixtures of mononuclear organic Ga(III) complexes, Ga(III) (hydr) oxide, and free Ga(III) (here defined as the hydrated Ga(III) ion and its soluble hydrolysis products). Moreover, the EXAFS results showed significantly higher contribution from second-shell C atoms (9-11) for the Ga(III)-organic complexes at the lowest concentration (101-125 mu g g(-1), pH 4.9-5.1), indicating formation of cage-like structures similar to Ga(III)-EDTA. Our combined results showed that Ga(III)-NOM interactions can be of importance for the solubility and speciation of Ga in environmental systems. Furthermore, the similarities between Ga(III) and previous Fe(III) results demonstrate that Ga(III) can be utilized as a probe for metal(III)-NOM interactions over an extended experimental range (e. g., pH and metal concentration) and thereby improve our knowledge about these interactions in general. (C) 2014 Elsevier Ltd. All rights reserved.
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10.
  • Hahn-Strömberg, Victoria, 1971-, et al. (författare)
  • Polymorphisms in the CLDN1 and CLDN7 genes are related to differentiation and tumor stage in colon carcinoma
  • 2014
  • Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - Wiley-Blackwell. - 0903-4641 .- 1600-0463. ; 122:7, s. 636-642
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Tight junction is composed of transmembrane proteins important for maintaining cell polarity and regulating ion flow. Among these proteins are the tissue-specific claudins, proteins that have recently been suggested as tumor markers for several different types of cancer. An altered claudin expression has been observed in colon, prostatic, ovarian, and breast carcinoma. The aim of this study was to analyze the allele frequencies of three common single nucleotide polymorphisms (SNPs) in the genes for claudin 1 and claudin 7 in colon cancer (CC) patients and in a control population of healthy blood donors. Pyrosequencing was used to genotype the CLDN1 SNP rs9869263 (c.369C&gt;T), and the CLDN7 SNPs rs4562 (c.590C&gt;T) and rs374400 (c.606T&gt;G) in DNA from 102 formalin fixed paraffin embedded (FFPE) colon cancer tissue, and 111 blood leukocyte DNA from blood/plasma donors. These results were correlated with clinical parameters such as TNM stage, tumor localization, tumor differentiation, complexity index, sex, and age. We found that there was a significant association between the CLDN1 genotype CC in tumor samples and a higher risk of colon cancer development (OR 3.0, p &lt; 0.001). We also found that the CLDN7 rs4562 (c.590C&gt;T) genotype CT had a higher risk of lymph node involvement (p = 0.031) and a lower degree of tumor differentiation (p = 0.028). In the control population, the allele frequencies were very similar to those in the HapMap cohort for CLDN7. The CLDN1 rs9869263 genotype (c.369C&gt;T) was related to increased risk of colon cancer, and the CLDN7 rs4562 genotype (c.590C&gt;T) was related to tumor differentiation and lymph node involvement in colon carcinoma. Further studies are warranted to ascertain their potential uses as biomarkers predicting tumor development, proliferation, and outcome in this disease.</p>
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