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Sökning: WFRF:(Karpe Fredrik) > Chalmers tekniska högskola > Young women partiti...

Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.

Marinou, Kyriakoula (författare)
Adiels, Martin, 1976 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Department of Mathematical Sciences,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
Hodson, Leanne (författare)
visa fler...
Frayn, Keith N (författare)
Karpe, Fredrik (författare)
Fielding, Barbara A (författare)
visa färre...
 (creator_code:org_t)
2011
2011
Engelska.
Ingår i: The British journal of nutrition. - 1475-2662 .- 0007-1145. ; 105:6, s. 857-65
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Before the menopause, women are relatively protected against CVD compared with men. The reasons for this sex difference are not completely understood, but hepatic fatty acid metabolism may play a role. The present study aimed to investigate the utilisation of plasma NEFA by the liver and to determine whether they are partitioned differently into ketone bodies and VLDL-TAG in healthy, lean young men and women. Volunteers were studied during a prolonged overnight fast (12-19 h) using an intravenous infusion of [U-¹³C]palmitate. After 12 h fasting, the women had a more advantageous metabolic profile with lower plasma glucose (P < 0·05) and TAG (P < 0·05) but higher plasma NEFA (P < 0·05) concentrations. Plasma 3-hydroxybutyrate (3-OHB) concentrations rose more in women than in men, and the transfer of ¹³C from [U-¹³C]palmitate to plasma [¹³C]3-OHB reached a plateau 6-7 h after the start of the infusion in women but was still increasing at 6 h in men. This implies a slower 3-OHB production rate and/or dilution by other precursor pools in men. In women, the high isotopic enrichment of plasma 3-OHB suggested that systemic plasma fatty acids were the major source of 3-OHB production. However, in men, this was not observed during the course of the study (P < 0·01). There were no sex differences for the incorporation of ¹³C into VLDL1- or VLDL2-TAG. The ability of young women to partition fatty acids towards ketone body production rather than VLDL-TAG may contribute to their more advantageous metabolic profile compared with young men.

Nyckelord

3-Hydroxybutyric Acid
blood
Adult
Blood Glucose
metabolism
Carbon Isotopes
blood
Dietary Fats
metabolism
Fasting
physiology
Fatty Acids
Nonesterified
blood
Female
Humans
Lipoproteins
VLDL
blood
Liver
metabolism
Male
Palmitic Acid
metabolism
Postprandial Period
physiology
Premenopause
metabolism
Sex Factors
Triglycerides
blood
Young Adult
Sex Factors

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