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Sökning: WFRF:(Katsaros D)

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  • Tidskriftsartikel (refereegranskat)
  • Friedlander, Michael, et al. (författare)
  • Clinical trials in recurrent ovarian cancer.
  • 2011
  • Ingår i: International Journal of Gynecological Cancer. - : Lippincott Williams & Wilkins. - 1048-891X .- 1525-1438. ; 21:4, s. 771-775
  • Forskningsöversikt (refereegranskat)abstract
    • The 4th Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup was held in Vancouver, Canada, in June 2010. Representatives of 23 cooperative research groups studying gynecologic cancers gathered to establish international consensus on issues critical to the conduct of large randomized trials. Group C, 1 of the 3 discussion groups, examined recurrent ovarian cancer, and we report the consensus reached regarding 4 questions. These included the following: (1) What is the role of cytoreductive surgery for recurrent ovarian cancer? (2) How do we define distinct patient populations in need of specific therapeutic approaches? (3) Should end points for trials with recurrent disease vary from those of first-line trials? (4) Is CA-125 progression alone sufficient for entry/eligibility into clinical trials?
  • Kloukos, D, et al. (författare)
  • Gingival thickness assessment at the mandibular incisors with four methods : A cross-sectional study.
  • 2018
  • Ingår i: Journal of Periodontology. - : John Wiley & Sons. - 0022-3492 .- 1943-3670. ; 89:11, s. 1300-1309
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: This study was conducted to determine accuracy, precision and repeatability of four different methods for assessing gingival thickness METHODS: This cross-sectional study evaluated gingival thickness on 200 consecutively included orthodontic patients. Gingival thickness was assessed at both central mandibular incisors with: 1) transgingival probing with a standard periodontal probe, 2) transgingival probing with a stainless-steel acupuncture needle, 3) ultrasound, and 4) a color-coded periodontal probe. Intra-examiner reproducibility and method error were also evaluated. RESULTS: Transgingival measurements with the standard periodontal probe were found to be more accurate than those with the acupuncture needle, after method error assessment. Acupuncture needle and ultrasound device yielded higher values than the probe. Expected differences between the two methods were 22% more for the mandibular left central incisor (95% confidence interval (CI) = 11% to 32%) and 26% more (95% CI = 13% to 39%) for the mandibular right central incisor when measured with the needle. Ultrasound measurements exceeded probe measurements on average by 0.16 mm at mandibular left central incisor (95% CI = 0.14 to 0.18) and by 0.11 mm for mandibular right central incisor (95% CI = 0.08 to 0.13). Intraclass correlation coefficient concluded good agreement for the color-coded periodontal probe (0.624). CONCLUSIONS: Within the inherent limit of the uncertainty about the true value of gingival thickness, the present results demonstrate the differences between the tested methods, as far as accuracy and reproducibility are concerned. Based on the reproducibility, the transgingival probing with the periodontal probe as well as the ultrasound determination, seem to present an adequate choice for every day practice.
  • Thust, S. C., et al. (författare)
  • Glioma imaging in Europe : A survey of 220 centres and recommendations for best clinical practice
  • Ingår i: European Radiology. - : Springer. - 0938-7994. ; 28:8, s. 3306-3317
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: At a European Society of Neuroradiology (ESNR) Annual Meeting 2015 workshop, commonalities in practice, current controversies and technical hurdles in glioma MRI were discussed. We aimed to formulate guidance on MRI of glioma and determine its feasibility, by seeking information on glioma imaging practices from the European Neuroradiology community. Methods: Invitations to a structured survey were emailed to ESNR members (n=1,662) and associates (n=6,400), European national radiologists’ societies and distributed via social media. Results: Responses were received from 220 institutions (59% academic). Conventional imaging protocols generally include T2w, T2-FLAIR, DWI, and pre- and post-contrast T1w. Perfusion MRI is used widely (85.5%), while spectroscopy seems reserved for specific indications. Reasons for omitting advanced imaging modalities include lack of facility/software, time constraints and no requests. Early postoperative MRI is routinely carried out by 74% within 24–72 h, but only 17% report a percent measure of resection. For follow-up, most sites (60%) issue qualitative reports, while 27% report an assessment according to the RANO criteria. A minority of sites use a reporting template (23%). Conclusion: Clinical best practice recommendations for glioma imaging assessment are proposed and the current role of advanced MRI modalities in routine use is addressed. Key Points: • We recommend the EORTC-NBTS protocol as the clinical standard glioma protocol.• Perfusion MRI is recommended for diagnosis and follow-up of glioma.• Use of advanced imaging could be promoted with increased education activities.• Most response assessment is currently performed qualitatively.• Reporting templates are not widely used, and could facilitate standardisation.
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