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Sökning: WFRF:(Kedikoglou Simos)

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  • Mantzoros, Christos, et al. (författare)
  • Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns.
  • 2004
  • Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 151:6
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>OBJECTIVE:</strong> To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics.</p><p><strong>DESIGN:</strong> A cross-sectional study.</p><p><strong>METHODS:</strong> Three hundred and three newborns (Caucasian, singleton, full term, with a birth weight of &gt; or =2500 g, and apparently healthy) were included in the study. Blood samples were collected from the newborns no later than the fifth day of life for measurements of adiponectin and major IGF system components (IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3)). The data were analyzed using simple and multiple regression analyses.</p><p><strong>RESULTS:</strong> Adiponectin is substantially higher in neonates than in adults, with no evidence of the gender dimorphism observed among adults. We found an inverse association between neonatal adiponectin levels and newborn ponderal index and a positive association with newborn length by univariate analysis. We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors. In multivariate analysis, the inverse association between serum adiponectin and ponderal index does not remain significant after adjustment for potential confounding factors. In contrast, neonatal adiponectin levels correlate inversely significantly and independently with liver maturity and IGF-II and tend to remain positively associated with IGFBP-3 and increased birth length.</p><p><strong>CONCLUSIONS:</strong> An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors. In contrast, the positive association between serum adiponectin and birth length may reflect either a direct effect of adiponectin or an adiponectin-mediated increase in the sensitivity of tissues to insulin and components of the IGF system, and needs to be explored further.</p>
  • Skalkidou, Alkistis, et al. (författare)
  • Determinants and consequences of major insulin-like growth factor components among full-term healthy neonates.
  • 2003
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 12:9, s. 860-5
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The purpose of this research was to investigate determinants of the insulin-like growth factor (IGF) system among healthy full-term newborns and explore their relation with anthropometric variables at birth. Components of the IGF system have been implicated in the pathogenesis of several forms of cancer, and perinatal events have been linked to chronic diseases in later life. Measurements of weight and length, as well as blood samples, were obtained from 331 healthy full-term newborns delivered during 1999 in Athens, Greece. Because the liver is important for IGF production, newborns were chosen to have bilirubin levels either &lt; or = 8 mg/dl or &gt; or = 12 mg/dl to operationally distinguish them according to the liver function. IGF-I, IGF-II, and IGF binding protein-3 were inversely associated with the presence of neonatal jaundice and blood creatinine, after controlling for blood protein levels. IGF-I increased rapidly and significantly over a period of a few days and was strongly positively associated with both birth weight and ponderal index. Newborn levels of IGF-I declined with maternal age. In comparison with first-born newborns, later-born ones had significantly higher blood IGF-I levels. We conclude that IGF-I plays a dominant role in growth during the perinatal period and that all three studied components of the IGF system are sensitive to liver and kidney function. These findings provide an insight into the processes involved in perinatal growth.</p>
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