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Numrering	Referens	Omslagsbild	Hitta
1.	Smith, Gustav, et al. (författare) Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. 2014 Ingår i: JAMA: The Journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598. ; 312:17, s. 1764-1771 Tidskriftsartikel (refereegranskat)abstract Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.
2.	Thanassoulis, George, et al. (författare) Genetic Associations with Valvular Calcification and Aortic Stenosis 2013 Ingår i: New England Journal of Medicine. - 0028-4793. ; 368:6, s. 503-512 Tidskriftsartikel (refereegranskat)abstract Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, African-American, and Hispanic-American cohorts (P<0.05 for all comparisons). Genetically determined Lp(a) levels, as predicted by LPA genotype, were also associated with aortic-valve calcification, supporting a causal role for Lp(a). In prospective analyses, LPA genotype was associated with incident aortic stenosis (hazard ratio per allele, 1.68; 95% confidence interval [CI], 1.32 to 2.15) and aortic-valve replacement (hazard ratio, 1.54; 95% CI, 1.05 to 2.27) in a large Swedish cohort; the association with incident aortic stenosis was also replicated in an independent Danish cohort. Two SNPs (rs17659543 and rs13415097) near the proinflammatory gene IL1F9 achieved genomewide significance for mitral annular calcification (P = 1.5x10(-8) and P = 1.8x10(-8), respectively), but the findings were not replicated consistently. Conclusions Genetic variation in the LPA locus, mediated by Lp(a) levels, is associated with aortic-valve calcification across multiple ethnic groups and with incident clinical aortic stenosis. (Funded by the National Heart, Lung, and Blood Institute and others.)

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Smith, Gustav (2); Rotter, Jerome I. (2); Peloso, Gina M. (2); Kathiresan, Sekar (2); Harris, Tamara B (2); Gudnason, Vilmundur (2); visa fler...; O'Donnell, Christoph ... (2); Cupples, L. Adrienne (2); Post, Wendy S. (2); Smith, Albert V (2); Budoff, Matthew J. (2); Wong, Quenna (2); Kerr, Kathleen F. (2); Thanassoulis, George (2); Owens, David S (2); Melander, Olle (1); Nordestgaard, Borge ... (1); Sjögren, Marketa (1); Rukh, Gull (1); Almgren, Peter (1); Schulz, Christina Al ... (1); Orho-Melander, Marju (1); Tybjaerg-Hansen, Ann ... (1); Hindy, George (1); Aspelund, Thor (1); Heckbert, Susan R (1); Liu, Yongmei (1); Hwang, Shih-Jen (1); Do, Ron (1); Engert, James C. (1); vanderPals, Jesper (1); Pechlivanis, Sonali (1); Muehleisen, Thomas W ... (1); Sigurdsson, Sigurdur (1); Allison, Matthew A. (1); Criqui, Michael H. (1); Erbel, Raimund (1); Noethen, Markus M. (1); Dufresne, Line (1); Danesh, John (1); Di Angelantonio, Ema ... (1); Rich, Stephen (1); Malhotra, Rajeev (1); Campbell, Catherine ... (1); Kaelsch, Hagen (1); Kamstrup, Pia R. (1); Caslake, Muriel (1); Luk, Kevin (1); O'Brien, Kevin D. (1); visa färre...

Lärosäte: Lunds universitet (2)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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