| 1. |
- Sliz, E., et al.
(författare)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
- Grahn, T., et al.
(författare)
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Collectivity and configuration mixing in Pb186,188 and Po194
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:6
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of prolate intruder states in Pb186 and oblate intruder states in Po194 have been determined by employing, for the first time, the recoil-decay tagging technique in recoil distance Doppler-shift lifetime measurements. In addition, lifetime measurements of prolate states in Pb188 up to the 8+ state were carried out using the recoil-gating method. The B(E2) values have been deduced from which deformation parameters |β2|=0.29(5) and |β2|=0.17(3) for the prolate and the oblate bands, respectively, have been extracted. The results also shed new light on the mixing between different shapes.
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| 3. |
- Andreyev, A. N., et al.
(författare)
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In-beam and alpha-decay spectroscopy of Po-191 and evidence for triple shape coexistence at low energy in the daughter nucleus Pb-187
- 2002
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 66:1
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Tidskriftsartikel (refereegranskat)abstract
- Prompt gamma rays have been observed for the first time from the neutron-deficient nucleus Po-191 using the recoil-decay tagging technique at the RITU gas-filled separator. In addition improved alpha decay data have been measured for Po-191 and its daughter product Pb-187. The complementary gamma- and alpha-decay data point to the onset of oblate deformation in the light odd-mass Po nuclei by approaching the neutron midshell at N=104. The pattern of the favored and unfavored states observed on top of the 13/2(+) isomer in Po-191 indicates a change from the weak-coupling towards the strong-coupling scheme in Po-191m. In the daughter nucleus Pb-187, the 13/2(+) and 3/2(-) isomeric states become degenerate within the experimental accuracy. Evidence for triple shape coexistence at low energy has been found in the high-spin isomer in Pb-187. The results are supported by potential-energy surface calculations and by particle-plus-rotor calculations.
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| 4. |
- Bäck, Torbjörn, et al.
(författare)
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First observation of gamma-rays from the proton emitter Au-171
- 2003
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 16:4, s. 489-494
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Tidskriftsartikel (refereegranskat)abstract
- Gamma-rays from the alpha- and proton-unstable nuclide Au-171 have been observed for the first time. The gamma-rays were correlated with both a proton- and an alpha-particle decay branch, confirming that the nucleus decays by alpha and proton emission from a single (11/2(-)) state. The measurement confirms the previously determined half-lives for these particle decays but the present values are of higher precision. In addition, a longer half-life than determined in previous work was measured for the proton-unstable tentative ground state. The results are discussed in relation to structures in neighbouring nuclei and compared with a Strutinsky-type TRS calculation.
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| 5. |
- Bäck, Torbjörn, et al.
(författare)
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Spectroscopy of the neutron-deficient nuclide Pt-171
- 2003
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 17:1, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- A number of previously unobserved gamma-rays emitted from the neutron-deficient nuclide Pt-171 have been identified using the recoil decay tagging technique. The level scheme has been updated using information from gamma-gamma coincidences and angular distribution measurements. To further confirm the assignments of the gamma-rays to Pt-171, the events were correlated with the alpha-decay of the daughter nucleus Os-167.
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| 6. |
- Joss, D. T., et al.
(författare)
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The influence of quasineutron configurations on 161Ta and nearby odd-A nuclei
- 2011
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Ingår i: AIP Conf. Proc.. - : AIP. - 9780735409835 ; , s. 43-48
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Konferensbidrag (refereegranskat)abstract
- Several strongly coupled bands in the neutron-deficient nucleus 161Ta have been identified and quasiparticle configuration assignments have been made on the basis of rotational alignments and cranked shell model calculations. The level scheme elucidated for 161Ta highlights the competition between the ν(h 9/2) and ν(i 13/2) orbitals to form the yrast spectrum. The band structures in 161Ta also provide new insights into the structural features of other heavy odd-A nuclei populated with much lower reaction cross sections in this region at the proton drip line.
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| 7. |
- Van De Vel, K., et al.
(författare)
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In-beam gamma-ray spectroscopy of Po-190 : First observation of a low-lying prolate band in Po isotopes
- 2003
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 17:2, s. 167-171
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Tidskriftsartikel (refereegranskat)abstract
- Gamma rays from excited states of Po-190 have been observed using I the Jurosphere Ge-detector array coupled to the RITU gas-filled separator. They were associated with a collective band which from spin 4h onwards resembles the prolate rotational bands known in the isotones Pb-188 and Hg-186. This indicates that in Po-190 the prolate configuration becomes yrast above I = 2h. The experimental results are interpreted in a two-band mixing calculation and are in agreement with a-decay data and potential energy surface calculations.
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| 8. |
- Joss, D. T., et al.
(författare)
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Recoil decay tagging of gamma rays in the extremely neutron-deficient nucleus Os-162
- 2004
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Ingår i: Physical Review C. Nuclear Physics. - : American Physical Society. - 0556-2813 .- 1089-490X. ; 70:1
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Tidskriftsartikel (refereegranskat)abstract
- The neutron-deficient nucleus Os-162, produced in the Cd-106(Ni-58,2n) reaction, has been studied using the JUROGAM gamma-ray spectrometer in conjunction with the RITU gas-filled separator and the GREAT focal plane spectrometer. gamma-ray transitions in Os-162 have been assigned for the first time through the application of the recoil decay tagging technique. The excitation energy of the 2(+) state and the tentative energy of the 8(+) state are discussed in terms of the systematic energy trends as the N=82 shell gap is approached.
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| 9. |
- Joss, D. T., et al.
(författare)
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Yrast states and band crossings in the neutron-deficient platinum isotopes Pt169-173
- 2006
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 74:1
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Tidskriftsartikel (refereegranskat)abstract
- The yrast states in the light platinum isotopes Pt169-173 have been investigated in a recoil-decay tagging experiment using the JUROGAM gamma-ray spectrometer in conjunction with the RITU gas-filled recoil separator and the GREAT tagging spectrometer. Gamma-ray transitions have been established for the first time in the odd-N isotopes, Pt-169 and Pt-173, and the yrast sequences in Pt-170 and Pt-172 have been extended. We discuss the possibility that the weakly deformed yrast structures of Pt-170, Pt-172, and Pt-173 are crossed by a deformed intruder configuration at spin similar to 8h.
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| 10. |
- Lagergren, Karin, et al.
(författare)
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gamma-soft shapes and quasiparticle excitations in Ta-161(73)88
- 2011
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 83:1, s. 014313-
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in the neutron-deficient odd-Z nuclide Ta-161 were identified for the first time using the Cd-106(Ni-58,3p gamma) reaction at a beam energy of 270 MeV. The pi h(11/2) band, yrast at low spin, was observed up to (47/2(-)) and a further four strongly coupled bands have been established to high spin. Quasiparticle configuration assignments for the new band structures have been made on the basis of cranked shell model calculations. This work suggests that the negative-parity nu(f(7/2), h(9/2)) orbitals are responsible for the first rotational alignment in the pi h(11/2) band.
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