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Expression of the cytoskeleton linker protein ezrin in human cancers

Bruce, Benjamin (author)
Khanna, Gaurav (author)
Ren, Ling (author)
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Landberg, Göran (author)
Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
Jirström, Karin (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Powell, Charles (author)
Borczuk, Alain (author)
Keller, Evan T. (author)
Wojno, Kirk J. (author)
Meltzer, Paul (author)
Baird, Kristin (author)
McClatchey, Andrea (author)
Bretscher, Anthony (author)
Hewitt, Stephen M. (author)
Khanna, Chand (author)
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 (creator_code:org_t)
2007-03-17
2007
English.
In: Clinical and Experimental Metastasis. - : Springer Science and Business Media LLC. - 1573-7276 .- 0262-0898. ; 24:2, s. 69-78
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Expression of the metastasis-associated protein, ezrin, in over 5,000 human cancers and normal tissues was analyzed using tissue microarray immunohistochemistry. Ezrin staining was compared between cancers and their corresponding normal tissues, between cancers of epithelial and mesenchymal origin, in the context of the putative inhibitor protein, merlin, and against clinicopathological data available for breast, lung, prostate cancers and sarcomas. Ezrin was found in most cancers and normal tissues at varying levels of intensity. In general ezrin was expressed at higher levels in sarcomas than in carcinomas. By normalizing the expression of ezrin in each cancer using ezrin expression found in the corresponding normal tissue, significant associations between ezrin were found in advancing histological grade in sarcomas (P = 0.02) and poor outcome in breast cancer (P = 0.025). Clinicopathologic associations were not changed by simultaneous assessment of ezrin and merlin in each patient sample for the cancer types examined. These data support a role for ezrin in the biology of human cancers and the need for additional studies in breast cancer and sarcoma patients that may validate ezrin as a marker of cancer progression and as a potential target for cancer therapy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

tissue microarray
immunohistochemistry
ezrin
merlin
biomarker
prognosis

Publication and Content Type

art (subject category)
ref (subject category)

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