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- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 6. |
- El-Din, Mariam I. Gamal, et al.
(författare)
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Comparative LC-LTQ-MS-MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities
- 2022
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Ingår i: PLANTS. - : MDPI. - 2223-7747. ; 11:13
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Tidskriftsartikel (refereegranskat)abstract
- Lantana camara L. and Lantana montevidensis Briq. (F. Verbenaceae) are invasive ornamental weeds native to the tropical regions of Africa and America. The leaves of both species have been traditionally used as infusions for treating fever, rheumatism, and cancer. LC-MS-MS-guided profiling of the methanolic extracts of the leaves of L. camara and L. montevidensis growing in Egypt led to the putative identification of 59 compounds belonging to terpenoids, flavonoids, iridoid glycosides, phenolic acids, and their derivatives. The in vitro antioxidants and anti-inflammatory and anticancer activities of the two extracts were investigated. L. camara and L. montevidensis inhibited DPPH center dot (IC50 = 34.01 +/- 1.32 and 47.43 +/- 1.74 mu g/ mL), ABTS (IC50 = 30.73 +/- 1.42 and 40.37 +/- 1.51 mu g/mL), and superoxide anion (IC50 = 1.57 +/- 0.19 and 1.31 +/- 0.14 mu g/mL) free radicals. A potent antiinflammatory effect was observed for both species through the inhibition of elastase release in fMLF/CB-induced human neutrophils (IC50 = 2.40 +/- 0.16 and 1.90 +/- 0.07 mu g/mL). The extracts showed significant cytotoxic activity against a panel of cancer cell lines with the most potent activity against Caco cells (IC50 = 45.65 +/- 1.64 and 40.67 +/- 1.52 mu g /mL for L. camara and L. montevidensis, respectively). Western blotting supported by FACS analysis revealed that the extracts inhibited cancer cell proliferation, reduced metastasis, and induced apoptosis resulting in cell cycle arrest. This was achieved via increasing mRNA and protein expressions of p53 and GSK-313 as well as decreasing the expression of PI3K, Akt, and cyclin D1.
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| 7. |
- El-Seedi, Hesham R., et al.
(författare)
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Essential oil analysis of Micromeria nubigena HBK and its antimicrobial activity
- 2008
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Ingår i: The journal of essential oil research. - 1041-2905 .- 2163-8152. ; 20:5, s. 452-456
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Tidskriftsartikel (refereegranskat)abstract
- Water-distilled essential oil from leaves and flowers of Micromeria nubigena H.B.K. (Lamiaceae) were analyzed by GC and GUMS systems. The major components identified were thymol (36.9%), carvacrol (16.7%), pulegone (10.8%), caryophyllene oxide (4.6%) and (E)-phytol (3.2%). The major volatiles released by beta P-glucosidase treatment of the aqueous plant residue were (Z)-3-hexenol (31.2%), (4-2-hexenol (18.3%) and delta-cadinene (3.4%). The oil showed significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa, and antifungal activity against Candida albicans, Botrytis cinerea and Aspergillus niger, while the beta-glucosidase-liberated fraction was inactive.
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| 8. |
- Shah, S. A. W., et al.
(författare)
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ICIC-Enabled Association and Channel Selection for UAV-BSS Based on User Locations and Demands
- 2019
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Ingår i: 2019 IEEE Wireless Communications and Networking Conference Workshop, WCNCW 2019. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781728109220
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Konferensbidrag (refereegranskat)abstract
- In this work, the downlink association problem is studied when inter-cell interference coordination (ICIC) is enabled at the network side. The serving base stations (BSs) are mounted over unmanned aerial vehicles (UAVs), allowing for their initial placement as per the user geographic distribution. With recent air-to-ground channel modeling adopted herein, we focus on addressing the problem of coordinated channel assignment from within a reusable channel pool at each of the operator-deployed UAV-BSs along with the consideration of backhaul constraint. The joint association/channel assignment problem, which enables a flexible design of the inter-cell interference terms experienced by the users, is cast into a mixed integer linear program (MILP) that is numerically solved. Due to being a non-deterministic polynomial time (NP)-hard problem, the computation time may unboundedly grow, especially as the number of network nodes increases. To solve this problem, a low-complexity heuristic algorithm is proposed. The proposed heuristic solution is compared to that obtained via the MOSEK solver, revealing a close achievable performance with much less computational complexity.
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