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Genome-Wide Interac...
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
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- Smith, Caren E. (author)
- Tufts University
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- Follis, Jack L. (author)
- University of St Thomas, Houston
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- Dashti, Hassan S. (author)
- Broad Institute,Massachusetts General Hospital
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show more...
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- Tanaka, Toshiko (author)
- National Institute on Aging, United States
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- Graff, Mariaelisa (author)
- University of North Carolina
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- Fretts, Amanda M. (author)
- University of Washington
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- Kilpeläinen, Tuomas O. (author)
- University of Copenhagen
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- Wojczynski, Mary K. (author)
- Washington University in St. Louis
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- Richardson, Kris (author)
- Tufts University
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- Nalls, Mike A. (author)
- National Institute on Aging, United States,Kelly Services
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- Schulz, Christina Alexandra (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Liu, Yongmei (author)
- Wake Forest University
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- Frazier-Wood, Alexis C. (author)
- Baylor College of Medicine
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- van Eekelen, Esther (author)
- Leiden University Medical Centre
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- Wang, Carol (author)
- University of Western Australia, Crawley
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- de Vries, Paul S. (author)
- Erasmus University Medical Center,University of Texas
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- Mikkilä, Vera (author)
- University of Turku,University of Helsinki
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- Rohde, Rebecca (author)
- University of North Carolina
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- Psaty, Bruce M. (author)
- University of Washington,Group Health Cooperative
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- Hansen, Torben (author)
- University of Copenhagen
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- Feitosa, Mary F. (author)
- Washington University in St. Louis
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- Lai, Chao Qiang (author)
- Tufts University
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- Houston, Denise K. (author)
- Wake Forest University
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- Ferruci, Luigi (author)
- National Institute on Aging, United States
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Wang, Zhe (author)
- University of Texas
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- de Mutsert, Renée (author)
- Leiden University Medical Centre
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- Oddy, Wendy H. (author)
- University of Tasmania
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- de Jonge, Ester A.L. (author)
- Erasmus University Medical Center
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- Seppälä, Ilkka (author)
- University of Tampere
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- Justice, Anne E. (author)
- University of North Carolina
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- Lemaitre, Rozenn N. (author)
- University of Washington
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- Sørensen, Thorkild I.A. (author)
- University of Bristol,Bispebjerg Hospital,University of Copenhagen
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- Province, Michael A. (author)
- Washington University in St. Louis
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- Parnell, Laurence D. (author)
- Tufts University
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- Garcia, Melissa E. (author)
- National Institute on Aging, United States
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- Bandinelli, Stefania (author)
- Azienda Sanitaria Firenze (ASF)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Rich, Stephen S. (author)
- University of Virginia
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- Rosendaal, Frits R. (author)
- Leiden University Medical Centre
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- Pennell, Craig E. (author)
- University of Western Australia, Crawley
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- Kiefte-de Jong, Jessica C. (author)
- Erasmus University Medical Center
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- Kähönen, Mika (author)
- University of Tampere,Tampere University Hospital
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- Young, Kristin L. (author)
- University of North Carolina
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- Pedersen, Oluf (author)
- University of Copenhagen
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- Aslibekyan, Stella (author)
- University of Alabama
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- Rotter, Jerome I. (author)
- Harbor–UCLA Medical Center
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- Mook-Kanamori, Dennis O. (author)
- Leiden University Medical Centre
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- Zillikens, M. Carola (author)
- Erasmus University Medical Center
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- Raitakari, Olli T. (author)
- University of Turku
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- North, Kari E. (author)
- University of North Carolina
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- Overvad, Kim (author)
- Aarhus University,Aalborg University Hospital
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- Arnett, Donna K. (author)
- University of Kentucky
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- Hofman, Albert (author)
- Erasmus University Medical Center,Harvard University
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- Lehtimäki, Terho (author)
- University of Tampere
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Uitterlinden, André G. (author)
- Erasmus University Medical Center
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- Rivadeneira, Fernando (author)
- Netherlands Genomics Initiative,Erasmus University Medical Center
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- Franco, Oscar H. (author)
- Erasmus University Medical Center
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- German, J. Bruce (author)
- University of California, Davis
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- Siscovick, David S. (author)
- New York Academy of Medicine
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- Cupples, L. Adrienne (author)
- Boston University
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- Ordovás, José M. (author)
- Centro Nacional de Investigaciones Cardiovasculares Carlos III,IMDEA Institute,Tufts University
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(creator_code:org_t)
- 2017-12-11
- 2018
- English.
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In: Molecular Nutrition & Food Research. - : Wiley. - 1613-4125. ; 62:3
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- body mass index
- CHARGE consortium
- dairy intake
- genome-wide interaction study
- meta-analysis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Smith, Caren E.
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Follis, Jack L.
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Dashti, Hassan S ...
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Tanaka, Toshiko
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Graff, Mariaelis ...
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Fretts, Amanda M ...
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show more...
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Kilpeläinen, Tuo ...
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Wojczynski, Mary ...
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Richardson, Kris
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Nalls, Mike A.
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Schulz, Christin ...
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Liu, Yongmei
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Frazier-Wood, Al ...
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van Eekelen, Est ...
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Wang, Carol
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de Vries, Paul S ...
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Mikkilä, Vera
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Rohde, Rebecca
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Psaty, Bruce M.
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Hansen, Torben
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Feitosa, Mary F.
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Lai, Chao Qiang
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Houston, Denise ...
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Ferruci, Luigi
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Ericson, Ulrika
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Wang, Zhe
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de Mutsert, René ...
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Oddy, Wendy H.
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de Jonge, Ester ...
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Seppälä, Ilkka
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Justice, Anne E.
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Lemaitre, Rozenn ...
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Sørensen, Thorki ...
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Province, Michae ...
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Parnell, Laurenc ...
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Garcia, Melissa ...
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Bandinelli, Stef ...
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Orho-Melander, M ...
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Rich, Stephen S.
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Rosendaal, Frits ...
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Pennell, Craig E ...
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Kiefte-de Jong, ...
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Kähönen, Mika
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Young, Kristin L ...
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Pedersen, Oluf
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Aslibekyan, Stel ...
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Rotter, Jerome I ...
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Mook-Kanamori, D ...
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Zillikens, M. Ca ...
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Raitakari, Olli ...
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North, Kari E.
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Overvad, Kim
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Arnett, Donna K.
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Hofman, Albert
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Lehtimäki, Terho
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Tjønneland, Anne
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Uitterlinden, An ...
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Rivadeneira, Fer ...
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Franco, Oscar H.
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German, J. Bruce
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Siscovick, David ...
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Cupples, L. Adri ...
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Ordovás, José M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular Nutrit ...
- By the university
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Lund University