SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kiemeney Lambertus A.) "

Sökning: WFRF:(Kiemeney Lambertus A.)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Tidskriftsartikel (refereegranskat)
  •  
2.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
  •  
3.
  • Tidskriftsartikel (refereegranskat)
  •  
4.
  •  
5.
  • Franceschini, N., et al. (författare)
  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
  • 2018
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
  •  
6.
  •  
7.
  • Hollestelle, Antoinette, et al. (författare)
  • No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
  • Ingår i: Gynecologic Oncology. - : Academic Press. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
  •  
8.
  • Wood, Andrew R, et al. (författare)
  • Defining the role of common variation in the genomic and biological architecture of adult human height.
  • 2014
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186
  • Tidskriftsartikel (refereegranskat)abstract
    • Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
  •  
9.
  •  
10.
  • Tidskriftsartikel (refereegranskat)
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (92)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (92)
övrigt vetenskapligt (1)
Författare/redaktör
Kiemeney, Lambertus ... (82)
Kiemeney, LA (36)
Khaw, Kay-Tee (30)
Stefansson, Kari (29)
Overvad, Kim (28)
Trichopoulou, Antoni ... (27)
visa fler...
Tumino, Rosario (26)
Riboli, Elio (26)
Amos, Christopher I. (26)
Brennan, Paul (26)
Bueno-de-Mesquita, H ... (25)
Le Marchand, Loïc (25)
Stefansson, K (25)
Chanock, Stephen J (24)
Wichmann, H. Erich (24)
Thorsteinsdottir, Un ... (24)
Bojesen, Stig E. (23)
Boeing, Heiner (22)
Uitterlinden, Andre ... (22)
Thorleifsson, Gudmar (22)
Chang-Claude, Jenny (20)
Sánchez, Maria-José (20)
Montgomery, Grant W. (20)
Martin, Nicholas G. (20)
Allen, Naomi E. (20)
Johansson, Mattias (20)
Samani, Nilesh J. (20)
Thorleifsson, G (20)
Aldrich, Melinda C (20)
Feitosa, Mary F. (20)
Chang-Claude, J (19)
Wareham, Nicholas J (19)
Peeters, Petra H M (19)
Thorsteinsdottir, U (19)
Loos, Ruth J F (19)
Harris, Tamara B (19)
Esko, Tonu (19)
Jackson, Anne U. (19)
Khaw, KT (18)
Melander, Olle (18)
Palli, Domenico (18)
Ridker, Paul M. (18)
Chasman, Daniel I. (18)
Mohlke, Karen L (18)
Wilson, James F. (18)
Rennert, Gad (18)
North, Kari E (18)
Hirschhorn, Joel N. (18)
Lindgren, Cecilia M. (18)
Winkler, Thomas W. (18)
visa färre...
Lärosäte
Lunds universitet (54)
Umeå universitet (50)
Karolinska Institutet (24)
Uppsala universitet (17)
Göteborgs universitet (14)
Linköpings universitet (2)
visa fler...
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (93)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (81)
Naturvetenskap (3)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy