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Cord serum metaboli...
Cord serum metabolic signatures of future progression to immune-mediated diseases
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,School of Science and Technology, Örebro University, 702 81 Örebro, Sweden,Orebro Univ, Sweden
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- Bagavathy Shanmugam, Karthikeyan, 1987- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,School of Medical Sciences, Örebro University, Sweden,Orebro Univ, Sweden; Orebro Univ, Sweden
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- Ghaffarzadegan, Tannaz (författare)
- School of Science and Technology, Örebro University, 702 81 Örebro, Sweden,Orebro Univ, Sweden
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- Triplett, Eric W. (författare)
- Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences University of Florida, Gainesville, FL 32611-0700, USA,Univ Florida, FL 32611 USA
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland,Orebro Univ, Sweden; Univ Turku, Finland
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- Ludvigsson, Johnny (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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(creator_code:org_t)
- Cell Press, 2023
- 2023
- Engelska.
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 26:3
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Health sciences
- Human metabolism
- Immunology
- Lipidomics
- Metabolomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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