1. |
|
|
2. |
|
|
3. |
|
|
4. |
|
|
5. |
- Lyonnet, Julien R., et al.
(författare)
-
Photocatalytic Multicomponent Radical Coupling for the Direct Incorporation of Labeled Carbon Dioxide
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Isotope labelling is of utmost importance when it comes to ADME studies in the pharmaceutical industry. We hence report a synthetic procedure granting access to molecularly complex moieties from simpler starting materials as a four-component coupling reaction triggered by photochemical conditions. Using carbon dioxide as a coupling partner allows for the insertion of isotopically enriched carbon into molecules. The protocol shown here proceeds through a sequence of radical couplings based on polarity match initiated from sodium sulfinates as sulfonyl, electron-poor, radical. Malonates are also accessible from a slight modification of the general procedure, giving a double formal addition of carbon dioxide.
|
|
6. |
|
|