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Model validity of r...
Model validity of randomised placebo-controlled trials of non-individualised homeopathic treatment
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- Mathie, R. T. (författare)
- Homeopathy Research Institute, London, UK
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- Van Wassenhoven, M. (författare)
- FAMHP (Federal Agency for Medicines and Health Products), Belgium
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- Rutten, L. (författare)
- Independent Researcher, United States
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- Klein-Laansma, C. T. (författare)
- Louis Bolk Institute, Driebergen, Netherlands
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- Eizayaga, J. (författare)
- Maimonides University, Buenos Aires, Argentina
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- Pla i Castellsagué, A. (författare)
- European Committee for Homeopathy, Belgium
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- Jong, Miek C., 1968- (författare)
- Mittuniversitetet,Avdelningen för omvårdnad,Louis Bolk Institute, Driebergen, Netherlands; National Information and Knowledge Centre for Integrative Medicine, Netherlands
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- Manchanda, R. K. (författare)
- Central Council for Research in Homoeopathy, India
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- Dantas, F. (författare)
- Federal University of Uberlândia, Uberlândia, Brazil
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- Oberbaum, M. (författare)
- Shaare Zedek Medical Center, Jerusalem, Israel
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- Frye, J. (författare)
- University of Maryland School of Medicine, Baltimore, MD, United States
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- Roniger, H. (författare)
- Royal London Hospital for Integrated Medicine, London, United Kingdom
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- Baumgartner, S. (författare)
- University of Witten-Herdecke, Germany
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- van Haselen, R. (författare)
- International Institute for Integrated Medicine, Kingston, United Kingdom
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- Nicolai, T. (författare)
- Independent Researcher, United States
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- Fisher, P. (författare)
- Royal London Hospital for Integrated Medicine, London, United Kingdom
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(creator_code:org_t)
- 2018-01-02
- 2017
- Engelska.
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Ingår i: Homeopathy. - : Georg Thieme Verlag KG. - 1475-4916 .- 1476-4245. ; 106:4, s. 194-202
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background The comprehensive systematic review of randomised placebo-controlled trials (RCTs) in homeopathy requires examination of a study's model validity of homeopathic treatment (MVHT) as well as its risk of bias (extent of reliable evidence). Objective To appraise MVHT in those RCTs of non-individualised homeopathy that an associated investigation had judged as ‘not at high risk of bias’. Design Systematic review. Methods An assessment of MVHT was ascribed to each of 26 eligible RCTs. Another 49 RCTs were ineligible due to their high risk of bias. Main outcome measures MVHT and the prior risk of bias rating per trial were merged to obtain a single overall quality designation (‘high’, ‘moderate’, ‘low’), based on the GRADE principle of downgrading. Results The trials were rated as ‘acceptable MVHT’ (N = 9), ‘uncertain MVHT’ (N = 10) and ‘inadequate MVHT’ (N = 7); and, previously, as ‘reliable evidence’ (N = 3) and ‘non-reliable evidence’ (N = 23). The 26 trials were designated overall as: ‘high quality’ (N = 1); ‘moderate quality’ (N = 18); ‘low quality’ (N = 7). Conclusion Of the 26 RCTs of non-individualised homeopathy that were judged ‘not at high risk of bias’, nine have been rated ‘acceptable MVHT’. One of those nine studies was designated ‘high quality’ overall (‘acceptable MVHT’ and ‘reliable evidence’), and is thus currently the only reported RCT that represents best therapeutic practice as well as unbiased evidence in non-individualised homeopathy. As well as minimising risk of bias, new RCTs in this area must aim to maximise MVHT and clarity of reporting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- Model validity
- Non-individualised homeopathy
- Randomised placebo-controlled trials
- Risk of bias
- Systematic review
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- art (ämneskategori)
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Mathie, R. T.
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Van Wassenhoven, ...
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Rutten, L.
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Klein-Laansma, C ...
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Eizayaga, J.
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Pla i Castellsag ...
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visa fler...
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Jong, Miek C., 1 ...
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Manchanda, R. K.
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Dantas, F.
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Oberbaum, M.
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Frye, J.
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Roniger, H.
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Baumgartner, S.
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van Haselen, R.
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Nicolai, T.
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Fisher, P.
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