| 1. |
- Combes, Françoise, et al.
(författare)
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PKS 1413+135: OH and H i at z = 0.247 with MeerKAT
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 671
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Tidskriftsartikel (refereegranskat)abstract
- The BL Lac object PKS 1413+135 was observed by the Large Survey Project MeerKAT Absorption Line Survey (MALS) in the L-band, at 1139 MHz and 12931379 MHz, targeting the HI and OH lines in absorption at z=0.24671. The radio continuum might come from the nucleus of the absorbing galaxy or from a background object at redshift lower than 0.5, as suggested by the absence of gravitational images. The HI absorption line is detected at a high signal-To-noise ratio, with a narrow central component, and with a red wing, confirming previous results. The OH 1720 MHz line is clearly detected in (maser) emission, peaking at a velocity shifted by-10 to-15 km s-1 with respect to the HI peak. The 1612 MHz line is lost due to radio frequency interference. The OH 1667 MHz main line is tentatively detected in absorption, but not the 1665 MHz line. Over 30 years a high variability is observed in optical depths, due to the rapid changes of the line of sight caused by the superluminal motions of the radio knots. The HI line has varied by 20% in depth, while the OH-1720 MHz depth has varied by a factor of ∼3. The position of the central velocity and the widths also varied. The absorbing galaxy is an early-Type spiral (maybe S0) seen edge-on, with a prominent dust lane, covering the whole disk. Given the measured mass concentration and the radio continuum size at centimeter wavelengths (100 mas corresponding to 400 pc at z=0.25), the width of the absorption lines from the nuclear regions are expected up to 250 km s-1. The narrowness of the observed lines (< 15 km s-1) suggests that the absorption comes from an outer gas ring, as frequently observed in S0 galaxies. The millimetric lines are even narrower (< 1 km s-1), which corresponds to the continuum size restricted to the core. The radio core is covered by individual 1 pc molecular clouds, whose column density is a few 1022 cm-2, which is compatible with the gas screen detected in X-rays.
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| 2. |
- Dear, Alexander J., et al.
(författare)
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The catalytic nature of protein aggregation
- 2020
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 152:4
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Tidskriftsartikel (refereegranskat)abstract
- The formation of amyloid fibrils from soluble peptide is a hallmark of many neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Characterization of the microscopic reaction processes that underlie these phenomena have yielded insights into the progression of such diseases and may inform rational approaches for the design of drugs to halt them. Experimental evidence suggests that most of these reaction processes are intrinsically catalytic in nature and may display enzymelike saturation effects under conditions typical of biological systems, yet a unified modeling framework accounting for these saturation effects is still lacking. In this paper, we therefore present a universal kinetic model for biofilament formation in which every fundamental process in the reaction network can be catalytic. The single closed-form expression derived is capable of describing with high accuracy a wide range of mechanisms of biofilament formation and providing the first integrated rate law of a system in which multiple reaction processes are saturated. Moreover, its unprecedented mathematical simplicity permits us to very clearly interpret the effects of increasing saturation on the overall kinetics. The effectiveness of the model is illustrated by fitting it to the data of in vitro Aβ40 aggregation. Remarkably, we find that primary nucleation becomes saturated, demonstrating that it must be heterogeneous, occurring at interfaces and not in solution.
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