| 1. |
- Forouzanfar, Mohammad H, et al.
(författare)
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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
- 2015
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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| 2. |
- Gommenginger, Christine, et al.
(författare)
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SEASTAR: A mission to study ocean submesoscale dynamics and small-scale atmosphere-ocean processes in coastal, shelf and polar seas
- 2019
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Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 6:JUL
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- High-resolution satellite images of ocean color and sea surface temperature reveal an abundance of ocean fronts, vortices and filaments at scales below 10 km but measurements of ocean surface dynamics at these scales are rare. There is increasing recognition of the role played by small scale ocean processes in ocean-atmosphere coupling, upper-ocean mixing and ocean vertical transports, with advanced numerical models and in situ observations highlighting fundamental changes in dynamics when scales reach 1 km. Numerous scientific publications highlight the global impact of small oceanic scales on marine ecosystems, operational forecasts and long-term climate projections through strong ageostrophic circulations, large vertical ocean velocities and mixed layer re-stratification. Small-scale processes particularly dominate in coastal, shelf and polar seas where they mediate important exchanges between land, ocean, atmosphere and the cryosphere e.g. freshwater, pollutants. As numerical models continue to evolve towards finer spatial resolution and increasingly complex coupled atmosphere-wave-ice-ocean systems, modern observing capability lags behind, unable to deliver the high-resolution synoptic measurements of total currents, wind vectors and waves needed to advance understanding, develop better parameterizations and improve model validations, forecasts and projections. SEASTAR is a satellite mission concept that proposes to directly address this critical observational gap with synoptic two-dimensional imaging of total ocean surface current vectors and wind vectors at 1 km resolution and coincident directional wave spectra. Based on major recent advances in squinted along-track Synthetic Aperture Radar interferometry, SEASTAR is an innovative, mature concept with unique demonstrated capabilities, seeking to proceed towards spaceborne implementation within Europe and beyond.
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| 3. |
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| 4. |
- Helgeland, Øyvind, et al.
(författare)
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Characterization of the genetic architecture of infant and early childhood body mass index.
- 2022
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Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 4:3, s. 344-358
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Tidskriftsartikel (refereegranskat)abstract
- Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index at specific ages, matching different child growth phases, and representing four major trajectory patterns. We perform genome-wide association studies across 12 time points from birth to 8 years in 28,681 children and their parents (27,088 mothers and 26,239 fathers) in the Norwegian Mother, Father and Child Cohort Study. Monogenic obesity genes are overrepresented near identified loci, and several complex association signals near LEPR, GLP1R, PCSK1 and KLF14 point towards a major influence for common variation affecting the leptin-melanocortin system in early life, providing a link to putative treatment strategies. We also demonstrate how different polygenic risk scores transition from birth to adult profiles through early child growth. In conclusion, our results offer a fine-grained characterization of a changing genetic landscape sustaining early childhood growth.
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| 5. |
- Kassebaum, Nicholas J., et al.
(författare)
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Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015
- 2016
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 388:10053, s. 1603-1658
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Tidskriftsartikel (refereegranskat)abstract
- Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs off set by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2.9 years (95% uncertainty interval 2.9-3.0) for men and 3.5 years (3.4-3.7) for women, while HALE at age 65 years improved by 0.85 years (0.78-0.92) and 1.2 years (1.1-1.3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs. Interpretation Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum.
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| 6. |
- Kindberg, Elin, 1981-, et al.
(författare)
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Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark
- 2007
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Ingår i: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 45:8, s. 2720-2
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Tidskriftsartikel (refereegranskat)abstract
- A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
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| 7. |
- Krohn, Charlotte Fog, et al.
(författare)
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Litho- and chronostratigraphy of the Late Weichselian in Vendsyssel, northern Denmark, with special emphasis on tunnel-valley infill in relation to a receding ice margin
- 2009
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 38:4, s. 811-833
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Tidskriftsartikel (refereegranskat)abstract
- Lithostratigraphy and chronostratigraphy of samples from 18 deep boreholes in Vendsyssel have resulted in new insight into the Late Weichselian glaciation history of northern Denmark. Prior to the Late Weichselian Main advance c. 23-21 kyr BP, Vendsyssel was part of an ice-dammed lake where the Ribjerg Formation was deposited c. 27-23 kyr BP. The timing of the Late Weichselian deglaciation is well constrained by the Main advance and the Lateglacial marine inundation c. 18 kyr BP, and thus spans only a few millennia. Rapid deposition of more than 200 m of sediments took place mainly in a highly dynamic proglacial and ice-marginal environment during the overall ice recession. Mean retreat rates have been estimated as 45-50 m/yr in Vendsyssel with significantly higher retreat rates between periods of standstill and re-advance. The deglaciation commenced in Vendsyssel c. 20 kyr BP, and the Troldbjerg Formation was deposited c. 20-19 kyr BP in a large ice-dammed lake in front of the receding ice sheet, partly as glaciolacustrine sediments and partly as rapid and focused sedimentation in prominent ice-contact fans, which make up the Jyske As and Hammer Bakker moraines. In the northern part of central Vendsyssel, at least four generations of north-south orientated tunnel valleys are identified, each generation related to a recessional ice margin. This initial deglaciation was interrupted by a major re-advance from the east c. 19 kyr BP, which covered most of Vendsyssel. An ice-dammed lake formed in front of the ice sheet as it retreated towards the east; the Morild Formation was deposited here c. 19-18 kyr BP. Related to this stage of deglaciation, eight ice-marginal positions have been identified based on the distribution of large tunnel-valley systems and pronounced recessional moraines. The Morild Formation consists of glaciolacustrine sediments, including the sediment infill of more than 190 m deep tunnel valleys, as well as the sediments in recessional moraines, which were formed as ice-contact sedimentary ridges, possibly in combination with glaciotectonic deformation. The character of the tunnel-valley infill sediments was determined by proximity to the ice margin. During episodes of rapid retreat of the ice margin, tunnel valleys were quickly abandoned and filled with fine-grained sediments in a distal setting. During slow retreat of the ice margin, tunnel valleys were filled in an ice-proximal environment, and the infill consists of alternating layers of fine- to coarse-grained sediments. At c. 18 kyr BP, Vendsyssel was inundated by the sea, when the Norwegian Channel Ice Stream broke up, and a succession of marine sediments (Vendsyssel Formation) was deposited during a forced regression.
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| 8. |
- Larsen, Nicolaj Krog, et al.
(författare)
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Late Quaternary ice sheet, lake and sea history of southwest Scandinavia - a synthesis
- 2009
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 38:4, s. 732-761
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Forskningsöversikt (refereegranskat)abstract
- Based on a large number of new boreholes in northern Denmark, and on the existing data, a revised event-stratigraphy is presented for southwestern Scandinavia. Five significant Late Saalian to Late Weichselian glacial events, each separated by periods of interglacial or interstadial marine or glaciolacustrine conditions, are identified in northern Denmark. The first glacial event is attributed to the Late Saalian c. 160-140 kyr BP, when the Warthe Ice Sheet advanced from easterly and southeasterly directions through the Baltic depression into Germany and Denmark. This Baltic ice extended as far as northern Denmark, where it probably merged with the Norwegian Channel Ice Stream (NCIS) and contributed to a large discharge of icebergs into the Norwegian Sea. Following the break up, marine conditions were established that persisted from the Late Saalian until the end of the Early Weichselian. The next glaciation occurred c. 65-60 kyr BP, when the Sunds circle divide re ice advanced from the north into Denmark and the North Sea, where the Scandinavian and British Ice Sheets merged. During the subsequent deglaciation, large ice-dammed lakes formed before the ice disintegrated in the Norwegian Channel, and marine conditions were re-established. The following Ristinge advance from the Baltic, initiated c. 55 kyr BP, also reached northern Denmark, where it probably merged with the NCIS. The deglaciation, c. 50 kyr BP, was followed by a long period of marine arctic conditions. Around 30 kyr BP, the Scandinavian Ice Sheet expanded from the north into the Norwegian Channel, where it dammed the Kattegat ice lake. Shortly after, c. 29 kyr BP, the Kattegat advance began, and once again the Scandinavian and British Ice Sheets merged in the North Sea. The subsequent retreat to the Norwegian Channel led to the formation of Ribjerg ice lake, which persisted from 27 to 23 kyr BP. The expansion of the last ice sheet started c. 23 kyr BP, when the main advance occurred from north-northeasterly directions into Denmark. An ice-dammed lake was formed during deglaciation, while the NCIS was still active. During a re-advance and subsequent retreat c. 19 kyr BP, a number of tunnel-valley systems were formed in association with ice-marginal positions. The NCIS finally began to break up in the Norwegian Sea 18.8 kyr BP, and the Younger Yoldia Sea inundated northern Denmark around 18 kyr BP. The extensive amount of new and existing data applied to this synthesis has provided a better understanding of the timing and dynamics of the Scandinavian Ice Sheet (SIS) during the last c. 160 kyr. Furthermore, our model contributes to the understanding of the timing of the occasional release of large quantities of meltwater from the southwestern part of the SIS that are likely to enter the North Atlantic and possibly affect the thermohaline circulation.
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| 9. |
- Larsen, Nicolaj Krog, et al.
(författare)
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Lithostratigraphy of the Late Saalian to Middle Weichselian Skaerumhede Group in Vendsyssel, northern Denmark
- 2009
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 38:4, s. 762-786
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Tidskriftsartikel (refereegranskat)abstract
- The Quaternary sedimentary succession in Vendsyssel, northern Denmark, contains a unique, high-resolution record of the last interglacial and glacial periods. There is still much debate, however, about the timing and ice extent in this southwestern part of the Scandinavian Ice Sheet, particularly during the Middle Weichselian. In this study, a detailed lithostratigraphical subdivision is established for the Late Saalian to Middle Weichselian Skaerumhede Group on the basis of numerous, up to 250 m deep, boreholes in Vendsyssel. The sediments mainly consist of marine clays, glaciolacustrine sediments and tills, and the total thickness of the Skaerumhede Group is up to 140 m. Marine intervals have been used as stratigraphical marker units to separate the formations indicative of ice-sheet activity in Vendsyssel, and the timing of the events has been constrained by a large number of optically stimulated luminescence (OSL) and radiocarbon ages. The Skaerumhede Group is subdivided into seven formations and two members, reflecting shifts between marine and terrestrial sedimentation caused by fluctuations of the Scandinavian Ice Sheet and changes in sea level. The lowermost Skaerumhede Till Formation was deposited directly on top of the bedrock during the Warthe advance c. 160-140 kyr BP. Above, there are fine-grained marine sediments, subdivided into the Lower, Middle and Upper Skaerumhede Clay Formations. The marine formations are separated by the Br circle divide nderslev Formation related to the Sunds circle divide re ice advance from the north c. 65-60 kyr BP, and the Asted Formation, deposited during the Ristinge advance from an east-southeastern direction c. 55-50 kyr BP. The uppermost formation in the group is the L circle divide nstrup Klint Formation, which is an upwards-coarsening sequence of mainly glaciolacustrine sediments deposited prior to the Kattegat advance c. 30-29 kyr BP. The new evidence from Vendsyssel has shown that the Skaerumhede Group covers a large area, and that it can be used as a regional stratigraphical marker horizon. Furthermore, it contributes to a better understanding of the timing and extent of glacial events during the Late Saalian to Middle Weichselian in southwest Scandinavia.
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| 10. |
- LeBozec, Nathalie, et al.
(författare)
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Round-robin evaluation of ISO 20340 annex a test method
- 2016
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Ingår i: NACE - International Corrosion Conference Series. - 9781510821354 ; , s. 53-64
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Konferensbidrag (refereegranskat)abstract
- Among available standardized test methods for evaluating the performance of marine and offshore coatings, ISO 20340 Annex A is widely used.1 It is well known that tests performed on presumably identical materials in presumably similar circumstances do not in general yield to identical results. Such deviation is attributed to unavoidable random errors inherent in every test procedure and the fact that the parameters that may influence the outcome of a test cannot all be completely controlled. One consequence of such deviation is that different coating selection may be obtained upon where and how the test is performed, as ISO 20340 Annex A includes acceptance criteria for the selection of coating systems. Thus, to establish the precision of ISO 20340 Annex A, six laboratories participated in a round-robin evaluation of ISO 20340 Annex A test method for the first time. The aim was to estimate the repeatability and the reproducibility of this test upon laboratory, and eventually to determine how to improve the test method and the standard for the further revision of the standard. Five different painted systems applied on abrasive blasted steel were selected so that it included good and poor systems. The results of this study in terms of scribe creep and pull-off strength data were analyzed regarding the repeatability within a laboratory and lab-To-lab reproducibility.
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