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Genetic variants in...
Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality
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- Lin, Daniel W. (author)
- Department of Urology, University of Washington School of Medicine, Seattle, WA
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- FitzGerald, Liesel M. (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA
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- Fu, Rong (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Biostatistics, University of Washington, Seattle, WA
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- Kwon, Erika M. (author)
- Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD
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- Zheng, Siqun Lilly (author)
- Center for Cancer Genomics and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC
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- Kolb, Suzanne (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA
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- Wiklund, Fredrik (author)
- Karolinska Institutet
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- Stattin, Paer (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Isaacs, William B. (author)
- Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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- Xu, Jianfeng (author)
- Center for Cancer Genomics and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC
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- Ostrander, Elaine A. (author)
- Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD
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- Feng, Ziding (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Biostatistics, University of Washington, Seattle, WA
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- Grönberg, Henrik (author)
- Karolinska Institutet
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- Stanford, Janet L. (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington
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(creator_code:org_t)
- Philadelphia : American Association for Cancer Research, 2011
- 2011
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - Philadelphia : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 20:9, s. 1928-1936
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Prostate cancer is the second leading cause of cancer-related deaths in men, accounting for more than 30,000 deaths annually. The purpose of this study was to test whether variation in selected candidate genes in biological pathways of interest for prostate cancer progression could help distinguish patients at higher risk for fatal prostate cancer. Methods: In this hypothesis-driven study, we genotyped 937 single nucleotide polymorphisms (SNPs) in 156 candidate genes in a population-based cohort of 1,309 prostate cancer patients. We identified 22 top-ranking SNPs (P <= 0.01, FDR <= 0.70) associated with prostate cancer-specific mortality (PCSM). A subsequent validation study was completed in an independent population-based cohort of 2,875 prostate cancer patients. Results: Five SNPs were validated (P <= 0.05) as being significantly associated with PCSM, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes. Compared with patients with 0 to 2 of the at-risk genotypes those with 4 to 5 at-risk genotypes had a 50% (95% CI, 1.2-1.9) higher risk of PCSM and risk increased with the number of at-risk genotypes carried (P(trend) = 0.001), adjusting for clinicopathologic factors known to influence prognosis. Conclusion: Five genetic markers were validated to be associated with lethal prostate cancer. Impact: This is the first population-based study to show that germline genetic variants provide prognostic information for prostate cancer-specific survival. The clinical utility of this five-SNP panel to stratify patients at higher risk for adverse outcomes should be evaluated. Cancer Epidemiol Biomarkers Prev; 20(9); 1928-36. (C)2011 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Lin, Daniel W.
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FitzGerald, Lies ...
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Fu, Rong
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Kwon, Erika M.
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Zheng, Siqun Lil ...
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Kolb, Suzanne
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Wiklund, Fredrik
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Stattin, Paer
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Isaacs, William ...
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Xu, Jianfeng
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Ostrander, Elain ...
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Feng, Ziding
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Grönberg, Henrik
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Stanford, Janet ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancer Epidemiol ...
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Umeå University
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Karolinska Institutet