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1.	Böhm, Michael, et al. (author) Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study 2013 In: Clinical research in cardiology : official journal of the German Cardiac Society. - : Springer Science and Business Media LLC. - 1861-0692. ; 102:1, s. 11-22 Journal article (peer-reviewed)abstract BACKGROUND: We analysed the effect of ivabradine on outcomes in heart failure (HF) patients on recommended background therapies with heart rates >/=75 bpm and <75 bpm in the SHIFT trial. A cut-off value of >/=75 bpm was chosen by the EMEA for approval for the use of ivabradine in chronic heart failure. METHODS: The SHIFT population was divided by baseline heart rate >/=75 or <75 bpm. The effect of ivabradine was analysed for primary composite endpoint (cardiovascular death or HF hospitalization) and other endpoints. RESULTS: In the >/=75 bpm group, ivabradine reduced primary endpoint (HR 0.76, 95 % CI 0.68-0.85, P < 0.0001), all-cause mortality (HR 0.83, 95 % CI, 0.72-0.96, P = 0.0109), cardiovascular mortality (HR 0.83, 95 % CI, (0.71-0.97, P = 0.0166), HF death (HR 0.61, 95 % CI, 0.46-0.81, P < 0.0006), and HF hospitalization (HR 0.70, 95 % CI, 0.61-0.80, P < 0.0001). Risk reduction depended on heart rate after 28 days, with the best protection for heart rates <60 bpm or reductions >10 bpm. None of the endpoints was significantly reduced in the <75 bpm group, though there were trends for risk reductions in HF death and hospitalization for heart rate <60 bpm and reductions >10 bpm. Ivabradine was tolerated similarly in both groups. CONCLUSION: The effect of ivabradine on outcomes is greater in patients with heart rate >/=75 bpm with heart rates achieved <60 bpm or heart rate reductions >10 bpm predicting best risk reduction. Our findings emphasize the importance of identification of high-risk HF patients by high heart rates and their treatment with heart rate-lowering drugs such as ivabradine.
2.	Nieminen, Markku S, et al. (author) Executive summary of the guidelines on the diagnosis and treatment of acute heart failure : the Task Force on Acute Heart Failure of the European Society of Cardiology. 2005 In: Eur Heart J. - 0195-668X. ; 26:4, s. 384-416 Journal article (peer-reviewed)
3.	Swedberg, Karl, et al. (author) Guías de Práctica Clínica sobre el diagnóstico y tratamiento de la insuficiencia cardíaca crónica. Versión resumida (actualización 2005) [Guidelines for the Diagnosis and Treatment of Chronic Heart Failure: executive summary (update 2005)] 2005 In: Revista Española de Cardiología. - 0300-8932 .- 1579-2242. ; 58:9, s. 1062-1092 Journal article (peer-reviewed)
4.	Swedberg, Karl, et al. (author) Guidelines for the diagnosis and treatment of chronic heart failure : executive summary (update 2005) 2005 In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 26:11, s. 1115-1140 Journal article (peer-reviewed)

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Komajda, Michel (4); Tavazzi, Luigi (3); Drexler, Helmut (3); Nieminen, Markku S. (3); Swedberg, Karl (3); Follath, Ferenc (3); show more...; Smiseth, Otto A, (3); Gavazzi, Antonello (3); Jaarsma, Tiny (2); Böhm, Michael (2); Linde, Cecilia (2); Lopez-Sendon, Jose (2); Pierard, Luc (2); Morais, Joao (2); Cleland, John (2); Hoes, Arno (2); Korewicki, Jerzy (2); Lopez Sendon, José-L ... (2); Haverich, Axel (2); Lévy, Samuel (2); Swedberg, Karl, 1944 (1); Tendera, Michal (1); Dean, Veronica (1); Metra, Marco (1); Lindahl, Bertil (1); Dickstein, Kenneth (1); Mebazaa, Alexandre (1); Thygesen, Kristian (1); Budaj, Andrzej (1); Ferrari, Roberto (1); Cowie, Martin R (1); Priori, Silvia G (1); Blanc, Jean-Jacques (1); Burgos, Enrique Fern ... (1); Garcia, Maria Angele ... (1); Lekakis, John (1); Mazzotta, Gianfranco (1); Oto, Ali (1); Ford, Ian (1); Moreno, Rui (1); Borer, Jeffrey (1); Gonzalez-Juanatey, J ... (1); Reil, Jan-Christian (1); Jondeau, Guillaume (1); Filippatos, Gerasimo ... (1); Deckers, Jaap (1); Singer, Mervyn (1); Rhodes, Andrew (1); Hasin, Yonathan (1); Janssens, Uwe (1); show less...

University: Linköping University (2); University of Gothenburg (1); Uppsala University (1)

Language: English (3); Spanish (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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