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Direct glucocortico...
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
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- Engblom, David (author)
- German Cancer Research Centre
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- Kornfeld, Jan-Wilhelm (author)
- German Cancer Research Centre
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- Schwake, Lukas (author)
- German Cancer Research Centre
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- Tronche, Francois (author)
- German Cancer Research Centre
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- Reimann, Andreas (author)
- German Cancer Research Centre
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- Beug, Hartmut (author)
- German Cancer Research Centre
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- Hennighausen, Lothar (author)
- German Cancer Research Centre
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- Moriggl, Richard (author)
- German Cancer Research Centre
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- Schuetz, Guenther (author)
- German Cancer Research Centre
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(creator_code:org_t)
- 2007-05-15
- 2007
- English.
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In: Genes & Development. - : Csh Cold Spring Harbor Laboratory Press. - 0890-9369 .- 1549-5477. ; 21:10, s. 1157-1162
- Related links:
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http://genesdev.cshl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte- specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth- promoting effect of the glucocorticoid receptor through a direct interaction involving the N-terminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.
Keyword
- somatomedin; liver; Cre-loxP; growth hormone; microarray
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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