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Träfflista för sökning "WFRF:(Kovács Anikó 1961) ;pers:(Stenman Göran 1953)"

Search: WFRF:(Kovács Anikó 1961) > Stenman Göran 1953

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1.
  • Fehr, Andre, et al. (author)
  • The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma
  • 2011
  • In: The Journal of Pathology. - : Wiley. - 1096-9896 .- 0022-3417. ; 224:3, s. 322-7
  • Journal article (peer-reviewed)abstract
    • We have recently shown that the recurrent t(6;9)(q22 approximately 23;p23 approximately 24) translocation in adenoid cystic carcinoma (ACC) of the breast and head and neck results in a fusion of the two transcription factor genes MYB and NFIB. Here we demonstrate, for the first time, that benign sporadic, dermal cylindromas also express the MYB-NFIB gene fusion. RT-PCR and immunohistochemical analyses revealed that eight of 12 analysed tumours (67%) expressed MYB-NFIB fusion transcripts and/or stained positive for MYB protein. Nucleotide sequence analyses confirmed that the composition of the chimeric transcript variants identified was identical to that in ACC, suggesting a similar molecular mechanism of activation of MYB in cylindroma as in ACC. In contrast, no evidence for the presence of the MYB-NFIB fusion was found in other types of basaloid skin and salivary gland tumours, indicating that the fusion indeed has a restricted expression pattern. Our findings broaden the spectrum of neoplasms associated with MYB oncogene activation and reveal a novel genetic link between ACC and dermal cylindroma. These results, together with our previous observations, further strengthen the evidence for common molecular pathways of importance for the development of both benign and malignant breast, salivary and adnexal tumours.
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2.
  • Kovács, Anikó, 1961, et al. (author)
  • ALK-Positive Inflammatory Myofibroblastic Tumor of the Nipple During Pregnancy-An Unusual Presentation of a Rare Disease.
  • 2015
  • In: The breast journal. - : Hindawi Limited. - 1524-4741 .- 1075-122X. ; 21:3, s. 297-302
  • Journal article (peer-reviewed)abstract
    • Inflammatory myofibroblastic tumors (IMT) is a benign to low-grade malignant neoplasm most commonly occurring in the viscera and soft tissues of children and young adults. Involvement of the breast is very rare. This report presents the first case of IMT of the nipple and highlights the histologic features and differential diagnosis at this unusual anatomical site. The patient was a 31-years-old pregnant woman with a palpable mass at the upper half of the left nipple. The lesion appeared after breastfeeding of her first child and increased in size during her second pregnancy. A conservative, incomplete surgical excision was performed in the 24th week of the second pregnancy. The residual tumor subsequently underwent spontaneous regression. There was no evidence of disease 5years after surgery. FISH and immunohistochemical analyses revealed rearrangement and overexpression of the ALK gene, a typical feature of both pulmonary and extrapulmonary IMT.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Stenman, Göran, ... (2)Undo refine
Kovács, Anikó, 1961 (2)
Fehr, Andre (1)
Kindblom, Lars-Gunna ... (1)
Mattsson, Jan (1)
Loning, T. (1)
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Frierson, H., Jr. (1)
van den Oord, J. (1)
Máthé, Gyöngyvér (1)
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University
University of Gothenburg (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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