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Search: WFRF:(Kovar F) > Lund University

  • Result 1-3 of 3
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1.
  • Bölling, T, et al. (author)
  • Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.
  • 2015
  • In: Klinische Pädiatrie. - : Georg Thieme Verlag KG. - 1439-3824 .- 0300-8630. ; 227:3, s. 108-115
  • Research review (peer-reviewed)abstract
    • Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.
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2.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
3.
  • Zhao, Chaoyang, et al. (author)
  • A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor
  • 2015
  • In: Current Biology. - : Elsevier BV. - 1879-0445 .- 0960-9822. ; 25:5, s. 613-620
  • Journal article (peer-reviewed)abstract
    • Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms that these arthropods use to induce plant galls are poorly understood. We sequenced the genome of the Hessian fly (Mayetiola destructor; Diptera: Cecidomyiidae), a plant parasitic gall midge and a pest of wheat (Triticum spp.), with the aim of identifying genic modifications that contribute to its plant-parasitic lifestyle. Among several adaptive modifications, we discovered an expansive reservoir of potential effector proteins. Nearly 5% of the 20,163 predicted gene models matched putative effector gene transcripts present in the M. destructor larval salivary gland. Another 466 putative effectors were discovered among the genes that have no sequence similarities in other organisms. The largest known arthropod gene family (family SSGP-71) was also discovered within the effector reservoir. SSGP-71 proteins lack sequence homologies to other proteins, but their structures resemble both ubiquitin E3 ligases in plants and E3-ligase-mimicking effectors in plant pathogenic bacteria. SSGP-71 proteins and wheat Skp proteins interact in vivo. Mutations in different SSGP-71 genes avoid the effector-triggered immunity that is directed by the wheat resistance genes H6 and H9. Results point to effectors as the agents responsible for arthropod-induced plant gall formation.
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Type of publication
journal article (2)
research review (1)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Dunst, J (1)
Hjorth, Lars (1)
Rothhaupt, Karl-Otto (1)
Sauer, R (1)
Löfstedt, Christer (1)
Weigend, Maximilian (1)
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Müller, Jörg (1)
Farrell, Katharine N ... (1)
Islar, Mine (1)
Krause, Torsten (1)
Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Ladenstein, R (1)
Lukic, Marko (1)
Pereira, Laura (1)
Hoffmann, C (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Waterhouse, Robert M ... (1)
Engel, S (1)
Vajda, Vivi (1)
Pascual, Unai (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Johansson, Maria (1)
Martin, Jean Louis (1)
Olsson, Urban (1)
Hortal, Joaquin (1)
Buckley, Yvonne (1)
Petrovan, Silviu (1)
Schindler, Stefan (1)
Carvalho, Joana (1)
Delattre, O (1)
Amo, Luisa (1)
Machordom, Annie (1)
De Smedt, Pallieter (1)
Lindkvist, Emilie (1)
Andersson, Martin N. (1)
Matos-Maraví, Pável (1)
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University
Lund University  (3)Undo refine
Royal Institute of Technology (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
Language
English (3)
Research subject (UKÄ/SCB)
Natural sciences (2)
Engineering and Technology (1)
Medical and Health Sciences (1)
Social Sciences (1)

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