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Sökning: WFRF:(Kraemer Bernhard K.)

  • Resultat 1-10 av 28
  • [1]23Nästa
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1.
  • Tidskriftsartikel (refereegranskat)
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2.
  • Teumer, Alexander, et al. (författare)
  • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.
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3.
  • Adolph, C., et al. (författare)
  • Azimuthal asymmetries of charged hadrons produced in high-energy muon scattering off longitudinally polarised deuterons
  • 2018
  • Ingår i: European Physical Journal C. - : SPRINGER. - 1434-6044 .- 1434-6052. ; 78:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Single hadron azimuthal asymmetries of positive and negative hadrons produced in muon semi-inclusive deep inelastic scattering off longitudinally polarised deuterons are determined using the 2006 COMPASS data and also combined all deuteron COMPASS data. For each hadron charge, the dependence of the azimuthal asymmetry on the hadron azimuthal angle f is obtained by means of a fiveparameter fitting function that besides a f-independent term includes four modulations predicted by theory: sin f, sin 2f, sin 3f and cos f. The amplitudes of the five terms have been extracted, first, for the hadrons in the whole available kinematic region. In further fits, performed for hadrons from a restricted kinematic region, the f-dependence is determined as a function of one of three variables (Bjorken-x, fractional energy of virtual photon taken by the outgoing hadron and hadron transverse momentum), while disregarding the others. Except thef-independent term, all themodulation amplitudes are very small, and no clear kinematic dependence could be observed within experimental uncertainties.
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4.
  • Adolph, C., et al. (författare)
  • First measurement of the Sivers asymmetry for gluons using SIDIS data
  • 2017
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 772, s. 854-864
  • Tidskriftsartikel (refereegranskat)abstract
    • The Sivers function describes the correlation between the transverse spin of a nucleon and the transverse motion of its partons. For quarks, it was studied in previous measurements of the azimuthal asymmetry of hadrons produced in semi-inclusive deep inelastic scattering of leptons off transversely polarised nucleon targets, and it was found to be non-zero. In this letter the evaluation of the Sivers asymmetry for gluons is presented. The contribution of the photon-gluon fusion subprocess is enhanced by requiring two high transverse-momentum hadrons. The analysis method is based on a Monte Carlo simulation that includes three hard processes: photon-gluon fusion, QCD Compton scattering and the leading-order virtual-photon absorption process. The Sivers asymmetries of the three processes are simultaneously extracted using the LEPTO event generator and a neural network approach. The method is applied to samples of events containing at least two hadrons with large transverse momentum from the COMPASS data taken with a 160 GeV/c muon beam scattered off transversely polarised deuterons and protons. With a significance of about two standard deviations, a negative value is obtained for the gluon Sivers asymmetry. The result of a similar analysis for a Collins-like asymmetry for gluons is consistent with zero. (C) 2017 The Author(s). Published by Elsevier B.V.
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5.
  • Adolph, C., et al. (författare)
  • Multiplicities of charged kaons from deep-inelastic muon scattering off an isoscalar target
  • 2017
  • Ingår i: ; 767, s. 133-141
  • Tidskriftsartikel (refereegranskat)abstract
    • Precise measurements of charged-kaon multiplicities in deep inelastic scattering were performed. The results are presented in three-dimensional bins of the Bjorken scaling variable x, the relative virtual-photon energy y, and the fraction z of the virtual-photon energy carried by the produced hadron. The data were obtained by the COMPASS Collaboration by scattering 160 GeV muons off an isoscalar (LiD)-Li-6 target. They cover the kinematic domain 1 (GeV/c)(2) < Q(2) < 60 (GeV/c)(2) in the photon virtuality, 0.004 < x < 0.4, 0.1 < y < 0.7, 0.20 < z < 0.85, and W > 5 GeV/c(2) in the invariant mass of the hadronic system. The results from the sum of the z-integrated K+ and K- multiplicities at high x point to a value of the non-strange quark fragmentation function larger than obtained by the earlier DSS fit.
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6.
  • Adolph, C., et al. (författare)
  • Multiplicities of charged pions and charged hadrons from deep-inelastic scattering of muons off an isoscalar target
  • 2017
  • Ingår i: ; 764, s. 1-10
  • Tidskriftsartikel (refereegranskat)abstract
    • Multiplicities of charged pions and charged hadrons produced in deep-inelastic scattering were measured in three-dimensional bins of the Bjorken scaling variable x, the relative virtual-photon energy y and the relative hadron energy z. Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam and an isoscalar target ((LiD)-Li-6). They cover the kinematic domain in the photon virtuality Q(2) > 1 (GeV/c) 2, 0.004 < x < 0.4, 0.2 < z < 0.85 and 0.1 < y < 0.7. In addition, a leading-order pQCD analysis was performed using the pion multiplicity results to extract quark fragmentation functions.
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7.
  • Adolph, C., et al. (författare)
  • Sivers asymmetry extracted in SIDIS at the hard scales of the Drell-Yan process at COMPASS
  • 2017
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 770, s. 138-145
  • Tidskriftsartikel (refereegranskat)abstract
    • Eight proton transverse-spin-dependent azimuthal asymmetries are extracted in four regions of the photon virtuality Q(2) from the COMPASS 2010 semi-inclusive hadron measurements in deep inelastic muon nucleon scattering. These Q(2) regions correspond to the four regions of the di-muon mass root Q(2) used in the ongoing analyses of the COMPASS Drell-Yan measurements, which allows for a future direct comparison of the nucleon transverse-momentum-dependent parton distribution functions extracted from these two alternative measurements. In addition, for the azimuthal asymmetries induced by the Sivers transverse-momentum-dependent parton distribution function various two-dimensional kinematic dependences are presented. The integrated Sivers asymmetries are found to be positive with an accutacy that appears to be sufficient to test the sign change of the Sivers function predicted by Quantum Chromodynamics.
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8.
  • Adolph, C., et al. (författare)
  • Interplay among transversity induced asymmetries in hadron leptoproduction
  • 2016
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 753, s. 406-411
  • Tidskriftsartikel (refereegranskat)abstract
    • In the fragmentation of a transversely polarized quark several left-right asymmetries are possible for the hadrons in the jet. When only one unpolarized hadron is selected, it exhibits an azimuthal modulation known as the Collins effect. When a pair of oppositely charged hadrons is observed, three asymmetries can be considered, a di-hadron asymmetry and two single hadron asymmetries. In lepton deep inelastic scattering on transversely polarized nucleons all these asymmetries are coupled with the transversity distribution. From the high statistics COMPASS data on oppositely charged hadron-pair production we have investigated for the first time the dependence of these three asymmetries on the difference of the azimuthal angles of the two hadrons. The similarity of transversity induced single and di-hadron asymmetries is discussed. A new analysis of the data allows quantitative relationships to be established among them, providing for the first time strong experimental indication that the underlying fragmentation mechanisms are all driven by a common physical process.
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9.
  • Adolph, C., et al. (författare)
  • Resonance production and pi pi S-wave in pi(-) + p -> pi(-) pi(-) pi(+) + p(recoil) at 190 GeV/c
  • 2017
  • Ingår i: ; 95:3
  • Tidskriftsartikel (refereegranskat)abstract
    • The COMPASS collaboration has collected the currently largest data set on diffractively produced pi(-) pi(-) pi(+) final states using a negative pion beam of 190 GeV/c momentum impinging on a stationary proton target. This data set allows for a systematic partial-wave analysis in 100 bins of three-pion mass, 0.5 < m(3 pi) < 2.5 GeV/c(2), and in 11 bins of the reduced four-momentum transfer squared, 0.1 < t' < 1.0 (GeV/c)(2). This two-dimensional analysis offers sensitivity to genuine one-step resonance production, i.e. the production of a state followed by its decay, as well as to more complex dynamical effects in nonresonant 3 pi production. In this paper, we present detailed studies on selected 3p partial waves with J(PC) = 0(-+) ,1(++) ,2(-+) ,2(++) ,and 4(++). In these waves, we observe the well-known groundstate mesons as well as a new narrow axial-vector meson a(1)(1420) decaying into f(0) (980)pi. In addition, we present the results of a novel method to extract the amplitude of the pi(-)pi(+) subsystem with I(G)J(PC) = 0(+)0(++) in various partial waves from the pi(-)pi(-)pi(+) data. Evidence is found for correlation of the f (0)(980) and f(0)(1500) appearing as intermediate pi(-)pi(+) isobars in the decay of the known pi(1800) and pi(2)(1880).
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10.
  • Adolph, C., et al. (författare)
  • The spin structure function g(1)(p) of the proton and a test of the Bjorken sum rule
  • 2016
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 753, s. 18-28
  • Tidskriftsartikel (refereegranskat)abstract
    • New results for the double spin asymmetry A(1)(p) and the proton longitudinal spin structure function g(1)(p) are presented. They were obtained by the COMPASS Collaboration using polarised 200 GeV muons scattered off a longitudinally polarised NH3 target. The data were collected in 2011 and complement those recorded in 2007 at 160 GeV, in particular at lower values of x. They improve the statistical precision of g(1)(p)(x) by about a factor of two in the region x less than or similar to 0.02. A next-to-leading order QCD fit to the g(1) world data is performed. It leads to a new determination of the quark spin contribution to the nucleon spin, Delta Sigma, ranging from 0.26 to 0.36, and to a re-evaluation of the first moment of g(1)(p). The uncertainty of Delta Sigma is mostly due to the large uncertainty in the present determinations of the gluon helicity distribution. A new evaluation of the Bjorken sum rule based on the COMPASS results for the non-singlet structure function g(1)(NS) (x, Q(2)) yields as ratio of the axial and vector coupling constants vertical bar gA/gV vertical bar = 1.22 +/- 0.05 (stat.) +/- 0.10 (syst.), which validates the sum rule to an accuracy of about 9%.
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