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Sökning: WFRF:(Kristensen Steen D)

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  • Ravn, Hanne B., et al. (författare)
  • Effect of low-molecular-weight heparin (Tinzaparin) and unfractionated heparin on platelet aggregation
  • 1996
  • Ingår i: Clinical and Applied Thrombosis/Hemostasis. - : SAGE Publications. - 1076-0296. ; 2:3, s. 209-212
  • Tidskriftsartikel (refereegranskat)abstract
    • A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in potency. Subcutaneous administration of Tinzaparin in two different doses did not have any effect on platelet activity. In conclusion, Tinzaparin appears, like other LMWHs, to have less proaggregatory effect on platelets than UFH both in vitro and ex vivo.
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  • Kristensen, Steen D., et al. (författare)
  • Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011 : current status in 37 ESC countries
  • 2014
  • Ingår i: European Heart Journal. - 0195-668X .- 1522-9645. ; 35:29, s. 1957-1970
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries. Methods and results A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries. Conclusion Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged.
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  • Resultat 1-6 av 6
 
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