SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Krogh R.) "

Sökning: WFRF:(Krogh R.)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Bauer, M., et al. (författare)
  • Solar insolation in springtime influences age of onset of bipolar I disorder
  • 2017
  • Ingår i: Acta Psychiatrica Scandinavica. - 0001-690X. ; 136:6, s. 571-582
  • Forskningsöversikt (refereegranskat)abstract
    • Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
  •  
2.
  • de Jong, Simone, et al. (författare)
  • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
  • 2018
  • Ingår i: Communications Biology. - Nature Publishing Group. - 2399-3642. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
3.
  •  
4.
  •  
5.
  •  
6.
  • Key, T J, et al. (författare)
  • Circulating sex hormones and breast cancer risk factors in postmenopausal women : reanalysis of 13 studies.
  • 2011
  • Ingår i: British Journal of Cancer. - Nature Publishing Group. - 0007-0920. ; 105:5, s. 709-722
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.
  •  
7.
  • Machiela, Mitchell J., et al. (författare)
  • Characterization of Large Structural Genetic Mosaicism in Human Autosomes
  • 2015
  • Ingår i: American Journal of Human Genetics. - 0002-9297. ; 96:3, s. 487-497
  • Tidskriftsartikel (refereegranskat)abstract
    • Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (&gt;2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events &gt;2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
  •  
8.
  • Villa, L. L., et al. (författare)
  • High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up
  • 2006
  • Ingår i: British Journal of Cancer. - Nature Publishing Group. - 1532-1827. ; 95:11, s. 1459-1466
  • Tidskriftsartikel (refereegranskat)abstract
    • Human papillomavirus (HPV) causes cervical, vulvar, and vaginal cancers, precancerous dysplasia, and genital warts. We report data for the longest efficacy evaluation to date of a prophylactic HPV vaccine. In total, 552 women (16-23 years) were enrolled in a randomised, placebo-controlled study of a quadrivalent HPV 6/11/16/18L1 virus-like-particle vaccine with vaccination at months 0, 2, and 6. At regular intervals through 3 years, subjects underwent gynaecologic examination, cervicovaginal sampling for HPV DNA, serum anti-HPV testing, and Pap testing, with follow-up biopsy as indicated. A subset of 241 subjects underwent two further years of follow-up. At 5 years post enrolment, the combined incidence of HPV 6/11/16/18-related persistent infection or disease was reduced in vaccine-recipients by 96% (two cases vaccine versus 46 placebo). There were no cases of HPV 6/11/16/18-related precancerous cervical dysplasia or genital warts in vaccine recipients, and six cases in placebo recipients (efficacy = 100%; 95% CI:12-100%). Through 5 years, vaccine-induced anti-HPV geometric mean titres remained at or above those following natural infection. In conclusion, a prophylactic quadrivalent HPV vaccine was effective through 5 years for prevention of persistent infection and disease caused by HPV 6/11/16/18. This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts.
  •  
9.
  •  
10.
  • Chadeau-Hyam, M., et al. (författare)
  • Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis
  • 2014
  • Ingår i: Annals of Oncology. - 0923-7534. ; 25:5, s. 1065-1072
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND:B-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and the discovery of prediagnostic markers have the potential to improve the clinical course of these neoplasms.METHODS:We investigated in a prospective study global gene expression in peripheral blood mononuclear cells of 263 incident B-cell lymphoma cases, diagnosed between 1 and 17 years after blood sample collection, and 439 controls, nested within two European cohorts.RESULTS:Our analyses identified only transcriptomic markers for specific lymphoma subtypes; few markers of multiple myeloma (N = 3), and 745 differentially expressed genes in relation to future risk of chronic lymphocytic leukemia (CLL). The strongest of these associations were consistently found in both cohorts and were related to (B-) cell signaling networks and immune system regulation pathways. CLL markers exhibited very high predictive abilities of disease onset even in cases diagnosed more than 10 years after blood collection.CONCLUSIONS:This is the first investigation on blood cell global gene expression and future risk of B-cell lymphomas. We mainly identified genes in relation to future risk of CLL that are involved in biological pathways, which appear to be mechanistically involved in CLL pathogenesis. Many but not all of the top hits we identified have been reported previously in studies based on tumor tissues, therefore suggesting that a mixture of preclinical and early disease markers can be detected several years before CLL clinical diagnosis.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (20)
Typ av publikation
tidskriftsartikel (114)
annan publikation (1)
konferensbidrag (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (114)
övrigt vetenskapligt (3)
Författare/redaktör
Krogh, Vittorio (42)
Riboli, Elio (37)
Krogh, V (35)
Tjonneland, A (27)
Bueno-de-Mesquita, H ... (26)
Overvad, K (25)
visa fler...
Boeing, H (24)
Boeing, Heiner (24)
Tumino, Rosario (24)
Tjonneland, Anne (24)
Hallmans, Göran, (24)
Khaw, Kay-Tee (23)
Tumino, R (23)
Riboli, E (23)
Overvad, Kim (21)
Jenab, Mazda (21)
Trichopoulou, Antoni ... (20)
Kaaks, R (20)
Palli, Domenico, (20)
Vineis, Paolo (20)
Trichopoulou, A (20)
Panico, Salvatore, (19)
Panico, S (19)
Clavel-Chapelon, Fra ... (18)
Kaaks, Rudolf (18)
Trichopoulos, Dimitr ... (18)
Boutron-Ruault, Mari ... (17)
Clavel-Chapelon, F (17)
Quiros, Josè R (17)
Albanes, Demetrius (16)
Chanock, Stephen J (15)
Palli, D (15)
Peeters, Petra H. M. (15)
Hunter, David J. (15)
Kooperberg, Charles (15)
Hutchinson, Amy (14)
Tjønneland, Anne (13)
Weiderpass, Elisabet ... (13)
Ardanaz, Eva, (13)
Ferrari, Pietro (13)
Kraft, Peter (13)
Dorronsoro, Miren (13)
Barricarte, A (13)
Linseisen, Jakob (12)
Sánchez, Maria-José (12)
Virtamo, Jarmo (12)
Duell, Eric J. (12)
Jacobs, Eric J (12)
Zeleniuch-Jacquotte, ... (12)
Rothman, Nathaniel, (12)
visa färre...
Lärosäte
Umeå universitet (56)
Karolinska Institutet (51)
Lunds universitet (45)
Göteborgs universitet (11)
Uppsala universitet (7)
Linköpings universitet (3)
visa fler...
Chalmers tekniska högskola (3)
Kungliga Tekniska Högskolan (1)
Stockholms universitet (1)
Örebro universitet (1)
Högskolan i Skövde (1)
visa färre...
Språk
Engelska (115)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (79)
Teknik (6)
Naturvetenskap (3)
Lantbruksvetenskap (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy