Search: WFRF:(Krsek M.)
> Blumcke I. >
International recom...
International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods
-
Blumcke, I. (author)
-
Aronica, E. (author)
-
Miyata, H. (author)
-
show more...
-
Sarnat, H. B. (author)
-
Thom, M. (author)
-
Roessler, K. (author)
-
- Rydenhag, Bertil, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
-
Jehi, L. (author)
-
Krsek, P. (author)
-
Wiebe, S. (author)
-
Spreafico, R. (author)
-
show less...
-
(creator_code:org_t)
- 2016-02-03
- 2016
- English.
-
In: Epilepsia. - : Wiley. - 0013-9580. ; 57:3, s. 348-358
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Epilepsy surgery is an effective treatment in many patients with drug-resistant focal epilepsies. An early decision for surgical therapy is facilitated by a magnetic resonance imaging (MRI)visible brain lesion congruent with the electrophysiologically abnormal brain region. Recent advances in the pathologic diagnosis and classification of epileptogenic brain lesions are helpful for clinical correlation, outcome stratification, and patient management. However, application of international consensus classification systems to common epileptic pathologies (e.g., focal cortical dysplasia [FCD] and hippocampal sclerosis [HS]) necessitates standardized protocols for neuropathologic workup of epilepsy surgery specimens. To this end, the Task Force of Neuropathology from the International League Against Epilepsy (ILAE) Commission on Diagnostic Methods developed a consensus standard operational procedure for tissue inspection, distribution, and processing. The aims are to provide a systematic framework for histopathologic workup, meeting minimal standards and maximizing current and future opportunities for morphofunctional correlations and molecular studies for both clinical care and research. Whenever feasible, anatomically intact surgical specimens are desirable to enable systematic analysis in selective hippocampectomies, temporal lobe resections, and lesional or nonlesional neocortical samples. Correct orientation of sample and the sample's relation to neurophysiologically aberrant sites requires good communication between pathology and neurosurgical teams. Systematic tissue sampling of 5-mm slabs along a defined anatomic axis and application of a limited immunohistochemical panel will ensure a reliable differential diagnosis of main pathologies encountered in epilepsy surgery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Brain
- Neuropathology
- Epilepsy
- Seizure
- Malformation
- Tumor
- Encephalitis
- Neuron
- Glia
- TEMPORAL-LOBE EPILEPSY
- FOCAL CORTICAL DYSPLASIAS
- CLASSIFICATION
- TUMORS
- EXPERIENCE
- OUTCOMES
- SYSTEM
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Epilepsia
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Blumcke, I.
-
Aronica, E.
-
Miyata, H.
-
Sarnat, H. B.
-
Thom, M.
-
Roessler, K.
-
show more...
-
Rydenhag, Bertil ...
-
Jehi, L.
-
Krsek, P.
-
Wiebe, S.
-
Spreafico, R.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Epilepsia
- By the university
-
University of Gothenburg