SwePub
Sök i SwePub databas

  form:Ext_t

Träfflista för sökning "WFRF:(Kubo M) "

form:Search_simp_t: WFRF:(Kubo M)

  • navigation:Result_t 1-10 navigation:of_t 138
hitlist:Modify_result_t
   
hitlist:Enumeration_thitlist:Reference_thitlist:Reference_picture_thitlist:Find_Mark_t
1.
  • 2017
  • swepub:Mat__t
  •  
2.
  •  
3.
  •  
4.
  • Acharya, B. S., et al. (creator_code:aut_t)
  • Introducing the CTA concept
  • 2013
  • record:In_t: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
  • swepub:Mat_article_t (swepub:level_scientificother_t)abstract
    • The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
  •  
5.
  • Algaba, Juan-Carlos, et al. (creator_code:aut_t)
  • Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
  • 2021
  • record:In_t: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
  •  
6.
  • Mishra, A., et al. (creator_code:aut_t)
  • Stroke genetics informs drug discovery and risk prediction across ancestries
  • 2022
  • record:In_t: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
  •  
7.
  • Aartsen, M. G., et al. (creator_code:aut_t)
  • Very high-energy gamma-ray follow-up program using neutrino triggers from IceCube
  • 2016
  • record:In_t: Journal of Instrumentation. - 1748-0221 .- 1748-0221. ; 11
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • We describe and report the status of a neutrino-triggered program in IceCube that generates real-time alerts for gamma-ray follow-up observations by atmospheric-Cherenkov telescopes (MAGIC and VERITAS). While IceCube is capable of monitoring the whole sky continuously, high-energy gamma-ray telescopes have restricted fields of view and in general are unlikely to be observing a potential neutrino-flaring source at the time such neutrinos are recorded. The use of neutrino-triggered alerts thus aims at increasing the availability of simultaneous multi-messenger data during potential neutrino flaring activity, which can increase the discovery potential and constrain the phenomenological interpretation of the high-energy emission of selected source classes (e. g. blazars). The requirements of a fast and stable online analysis of potential neutrino signals and its operation are presented, along with first results of the program operating between 14 March 2012 and 31 December 2015.
  •  
8.
  • Actis, M., et al. (creator_code:aut_t)
  • Design concepts for the Cherenkov Telescope Array CTA : an advanced facility for ground-based high-energy gamma-ray astronomy
  • 2011
  • record:In_t: Experimental astronomy. - : Springer. - 0922-6435 .- 1572-9508. ; 32:3, s. 193-316
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.
  •  
9.
  • Abdalla, H., et al. (creator_code:aut_t)
  • Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
  • 2021
  • record:In_t: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics Publishing (IOPP). - 1475-7516. ; :2
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for gamma-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of gamma-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of gamma-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z = 2 and to constrain or detect gamma-ray halos up to intergalactic-magnetic-field strengths of at least 0.3 pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from gamma-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of gamma-ray cosmology.
  •  
10.
  • Ramdas, S., et al. (creator_code:aut_t)
  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
  • 2022
  • record:In_t: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
  •  
Skapa referenser, mejla, bekava och länka
  • navigation:Result_t 1-10 navigation:of_t 138
swepub:Mat_t
swepub:mat_article_t (130)
swepub:mat_conferencepaper_t (6)
swepub:mat_researchreview_t (1)
swepub:Level_t
swepub:level_refereed_t (131)
swepub:level_scientificother_t (6)
swepub:Hitlist_author_t
Kubo, H. (21)
Saito, T (17)
Barrio, J. A. (17)
Contreras, J. L. (17)
Dazzi, F. (17)
De Angelis, A. (17)
deldatabas:search_more_t
De Lotto, B. (17)
Doro, M. (17)
Lombardi, S. (17)
Lopez-Coto, R. (16)
Antonelli, L. A. (16)
Biland, A. (16)
Blanch, O. (16)
Bonnoli, G. (16)
Cortina, J. (16)
Covino, S. (16)
Dorner, D. (16)
Gaug, M. (16)
Kushida, J. (16)
Lindfors, E. (16)
Maneva, G. (16)
Martinez, M. (15)
Di Pierro, F. (15)
Font, L. (15)
Garczarczyk, M. (15)
Hadasch, D. (15)
Hrupec, D. (15)
Nishijima, K. (15)
Okada, Y. (14)
Bednarek, W. (14)
Elsaesser, D. (14)
Fruck, C. (14)
Moralejo, A. (14)
Paneque, D. (14)
Paredes, J. M. (14)
Ribo, M. (14)
Rico, J. (14)
Temnikov, P. (14)
Peters, A (13)
Rhode, W. (13)
Da Vela, P. (13)
Fonseca, M. V. (13)
Longo, F. (13)
Lopez, M. (13)
Mariotti, M. (13)
Noda, K. (13)
Persic, M. (13)
Prandini, E. (13)
Stamerra, A. (13)
Cerruti, M. (13)
deldatabas:search_less_t
swepub:Hitlist_uni_t
swepub_uni:ki_t (58)
swepub_uni:uu_t (34)
swepub_uni:umu_t (17)
swepub_uni:gu_t (15)
swepub_uni:su_t (15)
swepub_uni:lnu_t (13)
deldatabas:search_more_t
swepub_uni:lu_t (11)
swepub_uni:kth_t (9)
swepub_uni:cth_t (8)
swepub_uni:du_t (2)
swepub_uni:oru_t (1)
deldatabas:search_less_t
hitlist:Language_t
language:Eng_t (138)
hitlist:HSV_t
hsv:Cat_1_t (55)
hsv:Cat_3_t (29)
hsv:Cat_2_t (1)

hitlist:Year_t

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt tools:Close_t

tools:Permalink_label_t