| 1. |
- Oberemok, Volodymyr V., et al.
(author)
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Molecular Alliance of Lymantria dispar Multiple Nucleopolyhedrovirus and a Short Unmodified Antisense Oligonucleotide of Its Anti-Apoptotic IAP-3 Gene : A Novel Approach for Gypsy Moth Control
- 2017
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In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 18:11
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Journal article (peer-reviewed)abstract
- Baculovirus IAP (inhibitor-of-apoptosis) genes originated by capture of host genes. Unmodified short antisense DNA oligonucleotides (oligoDNAs) from baculovirus IAP genes can down-regulate specific gene expression profiles in both baculovirus-free and baculovirus-infected insects. In this study, gypsy moth (Lymantria dispar) larvae infected with multiple nucleopolyhedrovirus (LdMNPV), and LdMNPV-free larvae, were treated with oligoDNA antisense to the RING (really interesting new gene) domain of the LdMNPV IAP-3 gene. The results with respect to insect mortality, biomass accumulation, histological studies, RT-PCR, and analysis of DNA apoptotic fragmentation suggest that oligoRING induced increased apoptotic processes in both LdMNPV-free and LdMNPV-infected insect cells, but were more pronounced in the latter. These data open up possibilities for promising new routes of insect pest control using antisense phosphodiester DNA oligonucleotides.
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| 2. |
- Sergeev, V. A., et al.
(author)
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MMS Observations of Reconnection Separatrix Region in the Magnetotail at Different Distances From the Active Neutral X-Line
- 2021
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 126:2
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Journal article (peer-reviewed)abstract
- The region surrounding the reconnection separatrix consists of many particle and wave transient features (electron, cold and hot ion beams, Hall E&B fields, kinetic Alfven, LH, etc. waves) whose pattern and parameters may vary depending on the distance from active neutral line. We study nine quick MMS entries into the plasma sheet boundary layer (PSBL) from the tail lobe to address the meso-scale pattern and other characteristics of phenomena for active separatrix crossings as deduced from particle observations. The outermost thin layer (a fraction of ion inertial scale, d(i)) of low-density plasma consists of accelerated electron beams and lobe cold ions and displays density depletions (EBL region). It is followed by hot proton beam (PBL region) in which the plasma density grows from lobe-like towards plasma sheet-like values; the beam energy-dispersion is used to estimate the distance from the active neutral line. Thin (usually <= d(i)) region containing intense Hall-like Ez perturbations (HR) usually overlaps with EBL and PBL regions. It often includes correlated B perturbations suggesting the Alfven wave-related transport from the reconnection source; the estimated Alfvenic ratio delta E/(V-A delta B) varied between 0.3 and 1.3 in studied examples. The HR is associated with profound plasma property changes, including the heating of cold ion beams in its innermost part, it hosts intense structured field-aligned currents and intense E-field fluctuations. Surprisingly, most of abovementioned findings are valid for crossings observed at large distances from the reconnection region (exceeding a few tens Re or >100 d(i)) except for longer time-scales and larger spatial scales of the pattern.
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| 3. |
- Glasbey, JC, et al.
(author)
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- 2021
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swepub:Mat__t
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| 4. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 5. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 6. |
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| 7. |
- Zaitsev, I., et al.
(author)
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Cold ion energization at separatrices during magnetic reconnection
- 2021
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In: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 28:3
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Journal article (peer-reviewed)abstract
- Separatrices of magnetic reconnection host intense perpendicular Hall electric fields. The fields are produced by the decoupling of the ion and electron components and are associated with the in-plane electrostatic potential drop between the inflow and outflow regions. The width of these structures is typically less than the ion inertial length, which is small enough to demagnetize ions as they cross the layer. We investigate ion acceleration at separatrices by means of 2D particle-in-cell simulations of magnetic reconnection for two limiting cases: (1) a "GEM-like" setup (here GEM stands for geospace environmental modeling reconnection challenge) with the lobe ion thermal velocity equal to the thermal velocity of the initial current sheet ions, which is comparable to the Alfven velocity and (2) a "cold" ion setup, in which the temperature of the background lobe ions is 1/100 of the initial current sheet temperature. The separatrix Hall electric field is balanced by the ion inertia term in the cold background simulations. The effect is indicative of the quasi-steady local perpendicular acceleration. The electric field introduces a cross field beam of unmagnetized particles, which makes the ion distribution function strongly non-gyrotropic and susceptible to sub-ion scale instabilities. This acceleration mechanism nearly vanishes in the hot ion background simulations. Our particle-in-cell simulations are complemented by one-dimensional test particle calculations. They show that the hot ion particles experience energy-scattering after crossing the accelerating layer, whereas cold ions are uniformly energized up to the energies comparable to the electrostatic potential drop between the inflow and outflow regions.
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