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Sökning: WFRF:(Löfberg Helge)

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  • Grubb, Anders, et al. (författare)
  • Abnormal Metabolism of γ-Trace Alkaline Microprotein : The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis
  • 1984
  • Ingår i: New England Journal of Medicine. - Massachusetts Medical Society. - 0028-4793. ; 311:24, s. 1547-1549
  • Tidskriftsartikel (refereegranskat)abstract
    • ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.
  • Nilsson, Lisbet, et al. (författare)
  • Renal arteriovenous shunting in rejecting allograft, hydronephrosis, or haemorrhagic hypotension in the rat
  • 1994
  • Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - Oxford University Press. - 1460-2385. ; 9:11, s. 1634-1639
  • Tidskriftsartikel (refereegranskat)abstract
    • We studied the occurrence of arteriovenous (A-V) shunting in three experimental rat models, namely in rejecting allograft kidney, in uni- or bilateral ureteral obstruction, and in haemorrhagic hypotension. Isografted or sham-operated rats served as controls. Radiolabelled microspheres were injected into the renal artery and the increase in the amount of radioactivity in the lungs was considered to reflect A-V shunting in the kidney. In animals exposed to haemorrhage, with a blood pressure not less than 70% of the initial blood pressure, practically no shunting was seen. When animals were bled to a hypotension beyond the autoregulation, A-V shunting occurred inversely correlated to the degree of hypotension. In ureteral obstruction, a less marked but significant increase in shunting of microspheres to the lungs was found after 24 h of unilateral obstruction, irrespective of whether the spheres were injected into the obstructed or the contralateral kidney. Significant A-V shunting during the allograft rejection process was also demonstrated. Histologically, microspheres were found in afferent arterioles less frequently in kidneys with A-V shunting than in controls. These results indicate that A-V shunting is involved in haemorrhagic hypotension, renal graft rejection, and hydronephrosis. In the latter situation A-V shunting is probably regulated by a humoral factor. © 1994 European Dialysis and Transplant Association-European Renal Association.
  • Olafsson, Isleifur, et al. (författare)
  • Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitors cystatin C and kininogen
  • 1988
  • Ingår i: Scandinavian Journal of Clinical & Laboratory Investigation. - Informa Healthcare. - 1502-7686. ; 48:6, s. 573-582
  • Tidskriftsartikel (refereegranskat)abstract
    • Murine monoclonal antibodies against the major cysteine proteinase inhibitors of human biological fluids, cystatin C and kininogen, were produced. The cystatin C antibody, HCC3, with a Ka of 2times107 l/mol, increased the inhibition of papain by cystatin C and was suitable for use in immunoblotting, immunohistochemistry and in the construction of a sensitive sandwich enzyme immunoassay for quantification of cystatin C. It recognized not only free cystatin C but also cystatin C in complexes with cysteine proteinases. The kininogen antibody, HK4, was directed against the third, cysteine proteinase inhibitory domain of the heavy chain of kininogen (Ka=1times107 l/mol), but did not influence the papain inhibitory activity of kininogen. It reacted with free kininogen as well as kininogen in complex with cysteine proteinases. Both antibodies could be used for the production of specific immunosorbents.
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