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Träfflista för sökning "WFRF:(Löfberg Helge) ;pers:(Gudmundsson Gunnar)"

Sökning: WFRF:(Löfberg Helge) > Gudmundsson Gunnar

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1.
  • Grubb, Anders, et al. (författare)
  • Abnormal Metabolism of γ-Trace Alkaline Microprotein : The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis
  • 1984
  • Ingår i: New England Journal of Medicine. - 0028-4793. ; 311:24, s. 1547-1549
  • Tidskriftsartikel (refereegranskat)abstract
    • ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.
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2.
  • Grubb, Anders, et al. (författare)
  • Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis
  • 1987
  • Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 18:2, s. 431-440
  • Tidskriftsartikel (refereegranskat)abstract
    • Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in the birefringent amyloid deposits of the small arteries in the cerebrum, cerebellum, and leptomeninges of 10 Icelandic individuals with hereditary cerebral hemorrhage with amyloidosis. Specimens from other organs were investigated in one of the patients, and amyloid angiopathy characterized by an immunoreactivity of cystatin C was found in a submandibular lymph node. No immunoreactivity of amyloid fibril protein AA, kappa or lambda immunoglobulin light chain, or prealbumin was observed. Significantly low cerebrospinal fluid concentrations of cystatin C were found in all 9 investigated individuals with hereditary cerebral hemorrhage with amyloidosis. The concentrations of beta 2-microglobulin, albumin, and IgG in the cerebrospinal fluid were within normal limits. Isoelectric focusing showed that cystatin C from the cerebrospinal fluid of 9 patients with hereditary cerebral hemorrhage with amyloidosis had an isoelectric point identical to that of normal individuals. This investigation demonstrates that hereditary cerebral hemorrhage with amyloidosis may be diagnosed by two laboratory methods: immunohistochemical investigation of cystatin C in brain tissue specimens and quantitation of cystatin C in cerebrospinal fluid.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Grubb, Anders (2)
Jensson, Olafur (2)
Gudmundsson, Gun... (2)Ta bort avgränsningen
Löfberg, Helge (2)
Malm, Johan (1)
Nilsson, E (1)
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Arnason, A (1)
Arnason, Alfred (1)
Blöndal, H (1)
Thorsteinsson, Leifu ... (1)
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Lunds universitet (2)
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Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

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