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Sökning: WFRF:(Lambert Marie) > Övrigt vetenskapligt/konstnärligt

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  • Ahnström Waltersson, Marie, 1976-, et al. (författare)
  • miR-206 expression is downregulated in cyclin D1 amplified breast tumours
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Amplification in the 11q13 region has been found in around 15% of all breast cancers and is strongly correlated with oestrogen receptor (ER) positive tumours. We have previously found that amplification of at least one of the genes PAK1 or CCND1 is associated with decreased recurrencefree survival among ER+ patients. Other genes in the amplicon might also contribute to this effect and situated close to CCND1 are the FGF-3, -4 and - 19 genes. The FGF-4 protein has been shown to inhibit the expression of the ERα regulator miR-206 in chicken embryo. In this study we analysed 23 tumours with and 27 tumours without previously detected 11q13 amplification to explore if 11q13 amplification is associated with decreased levels of miR-206 and if miR-206 is associated with ER expression. Using real-time PCR, we found that miR-206 expression was inversely correlated to CCND1 and 11q13 amplification (P=0.016 and P=0.022 respectively). Tumours with low miR-206 expression had higher levels of ERα than tumours with intermediate and high expression (P=0.043). We conclude that miR-206 might be an important regulator of the ERα. Our finding that low mir-206 is associated with CCND1 amplification and thereby also FGF-4 amplification points towards the possibility of a miR-206 regulator, FGF-4 or another FGF, present in the amplicon.
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  • O'Malley, Grace, et al. (författare)
  • Physical Activity and Physical Fitness in Pediatric Obesity : What are the First Steps for Clinicians? Expert Conclusion from the 2016 ECOG Workshop
  • 2017
  • Ingår i: International Journal of Exercise Science. - 1939-795X. ; 10:4, s. 487-496
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • One of the main aims of the European Childhood Obesity Group (ECOG) is to assist healthcare workers in delivering evidence-based assessment and treatment of childhood obesity. Every year the ECOG Congress includes working groups whose objective is to highlight concerns faced by clinicians and practitioners who work in the field of pediatric obesity. This year, a working group was devoted to the assessment of physical activity and physical fitness in this population. The present commentary attempts to summarize the main themes identified by practitioners during these workshops in order to provide the basic and essential first steps required to address physical activity and fitness in children with obesity.
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