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Immunomodulators: F...
Immunomodulators: Friends or Enemies in Surgery for Crohns Disease?
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- Landerholm, Kalle (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Cty Hosp, Sweden
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- Kalman, Thordis Disa (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Wallon, Conny (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Myrelid, Pär (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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(creator_code:org_t)
- BENTHAM SCIENCE PUBL LTD, 2019
- 2019
- English.
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In: Current Drug Targets. - : BENTHAM SCIENCE PUBL LTD. - 1389-4501 .- 1873-5592. ; 20:13, s. 1384-1398
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Crohns disease may severely impact the quality of life and being a chronic disease it requires both medical and surgical treatment aimed at induction and maintenance of remission to prevent relapsing symptoms and the need for further surgery. Surgery in Crohns disease often has to be performed in patients with well-known risk factors of post-operative complications, particularly intra-abdominal septic complications. This review will look at the current knowledge of immunomodulating therapies in the peri-operative phase of Crohns disease. The influence of immunomodulators on postoperative complications is evaluated by reviewing available clinical reports and data from animal studies. Furthermore, the effect of immunomodulators on preventing or deferring primary as well as repeat surgery in Crohns disease is reviewed with particular consideration given to high-risk cohorts and timing of prophylaxis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Crohns disease; inflammatory bowel disease; surgery; immunomodulators; thiopurines; azathioprine; mercaptopurine
Publication and Content Type
- ref (subject category)
- for (subject category)
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