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Mesenchymal stromal...
Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.
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- Kinzer, M. (författare)
- Institute of Cell Biology, Histology and Embryology, Med Univ Graz, Graz, Austria
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- Hingerl, K. (författare)
- Institute of Cell Biology, Histology and Embryology, Med Univ Graz, Graz, Austria
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Institute of Cell Biology, Histology and Embryology, Med Univ Graz, Graz, Austria,NGBI
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- Reinisch, A. (författare)
- Department of Internal Medicine, Stem Cell Research Unit, Division of Hematology, Med Univ Graz, Graz, Austria
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- Strunk, D. (författare)
- Experimental & Clinical Cell Therapy Institute, Spinal Cord & Tissue Regeneration Center, Paracelsus Med Univ, Salzburg, Austria
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- Huppertz, B. (författare)
- Institute of Cell Biology, Histology and Embryology, Med Univ Graz, Graz, Austria
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- Lang, I. (författare)
- Institute of Cell Biology, Histology and Embryology, Med Univ Graz, Graz, Austria
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(creator_code:org_t)
- London : W. B. Saunders Co Ltd, 2014
- 2014
- Engelska.
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Ingår i: Placenta. - London : W. B. Saunders Co Ltd. - 0143-4004 .- 1532-3102. ; 35:7, s. 517-519
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cell transplantation is a promising strategy in regenerative medicine for revascularization of ischemic tissues. Based on our observation that placental mesenchymal stromal cells (PMSC) enhance endothelial cell viability in vitro via secretion of angiogenic factors, we asked whether PMSC support vascular growth in vivo. PMSC were isolated from amnion and placental endothelial cells (PLEC) from chorion and either separately or co-transplanted subcutaneously into immune-deficient mice. Co-transplantation resulted in a higher number of perfused human vessels (CD31+/vimentin+) containing mouse glycophorin A+ erythrocytes. Results indicate positive effects of PMSC on neovascularization in vivo, making them attractive candidates to create autologous PMSC/PLEC pairs for research and transplantation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Human placenta; Mesenchymal stromal cells; Vascularization; Angiogenesis; Mouse model
- Medicine
- Medicin
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- art (ämneskategori)
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Placenta
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