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The African coelacanth genome provides insights into tetrapod evolution

Amemiya, Chris T. (author)
Alfoeldi, Jessica (author)
Lee, Alison P. (author)
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Fan, Shaohua (author)
Philippe, Herve (author)
MacCallum, Iain (author)
Braasch, Ingo (author)
Manousaki, Tereza (author)
Schneider, Igor (author)
Rohner, Nicolas (author)
Organ, Chris (author)
Chalopin, Domitille (author)
Smith, Jeramiah J. (author)
Robinson, Mark (author)
Dorrington, Rosemary A. (author)
Gerdol, Marco (author)
Aken, Bronwen (author)
Biscotti, Maria Assunta (author)
Barucca, Marco (author)
Baurain, Denis (author)
Berlin, Aaron M. (author)
Blatch, Gregory L. (author)
Buonocore, Francesco (author)
Burmester, Thorsten (author)
Campbell, Michael S. (author)
Canapa, Adriana (author)
Cannon, John P. (author)
Christoffels, Alan (author)
De Moro, Gianluca (author)
Edkins, Adrienne L. (author)
Fan, Lin (author)
Fausto, Anna Maria (author)
Feiner, Nathalie (author)
Forconi, Mariko (author)
Gamieldien, Junaid (author)
Gnerre, Sante (author)
Gnirke, Andreas (author)
Goldstone, Jared V. (author)
Haerty, Wilfried (author)
Hahn, Mark E. (author)
Hesse, Uljana (author)
Hoffmann, Steve (author)
Johnson, Jeremy (author)
Karchner, Sibel I. (author)
Kuraku, Shigehiro (author)
Lara, Marcia (author)
Levin, Joshua Z. (author)
Litman, Gary W. (author)
Mauceli, Evan (author)
Miyake, Tsutomu (author)
Mueller, M. Gail (author)
Nelson, David R. (author)
Nitsche, Anne (author)
Olmo, Ettore (author)
Ota, Tatsuya (author)
Pallavicini, Alberto (author)
Panji, Sumir (author)
Picone, Barbara (author)
Ponting, Chris P. (author)
Prohaska, Sonja J. (author)
Przybylski, Dariusz (author)
Saha, Nil Ratan (author)
Ravi, Vydianathan (author)
Ribeiro, Filipe J. (author)
Sauka-Spengler, Tatjana (author)
Scapigliati, Giuseppe (author)
Searle, Stephen M. J. (author)
Sharpe, Ted (author)
Simakov, Oleg (author)
Stadler, Peter F. (author)
Stegeman, John J. (author)
Sumiyama, Kenta (author)
Tabbaa, Diana (author)
Tafer, Hakim (author)
Turner-Maier, Jason (author)
van Heusden, Peter (author)
White, Simon (author)
Williams, Louise (author)
Yandell, Mark (author)
Brinkmann, Henner (author)
Volff, Jean-Nicolas (author)
Tabin, Clifford J. (author)
Shubin, Neil (author)
Schartl, Manfred (author)
Jaffe, David B. (author)
Postlethwait, John H. (author)
Venkatesh, Byrappa (author)
Di Palma, Federica (author)
Lander, Eric S. (author)
Meyer, Axel (author)
Lindblad-Toh, Kerstin (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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 (creator_code:org_t)
2013-04-17
2013
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 496:7445, s. 311-316
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

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By the author/editor
Amemiya, Chris T ...
Alfoeldi, Jessic ...
Lee, Alison P.
Fan, Shaohua
Philippe, Herve
MacCallum, Iain
show more...
Braasch, Ingo
Manousaki, Terez ...
Schneider, Igor
Rohner, Nicolas
Organ, Chris
Chalopin, Domiti ...
Smith, Jeramiah ...
Robinson, Mark
Dorrington, Rose ...
Gerdol, Marco
Aken, Bronwen
Biscotti, Maria ...
Barucca, Marco
Baurain, Denis
Berlin, Aaron M.
Blatch, Gregory ...
Buonocore, Franc ...
Burmester, Thors ...
Campbell, Michae ...
Canapa, Adriana
Cannon, John P.
Christoffels, Al ...
De Moro, Gianluc ...
Edkins, Adrienne ...
Fan, Lin
Fausto, Anna Mar ...
Feiner, Nathalie
Forconi, Mariko
Gamieldien, Juna ...
Gnerre, Sante
Gnirke, Andreas
Goldstone, Jared ...
Haerty, Wilfried
Hahn, Mark E.
Hesse, Uljana
Hoffmann, Steve
Johnson, Jeremy
Karchner, Sibel ...
Kuraku, Shigehir ...
Lara, Marcia
Levin, Joshua Z.
Litman, Gary W.
Mauceli, Evan
Miyake, Tsutomu
Mueller, M. Gail
Nelson, David R.
Nitsche, Anne
Olmo, Ettore
Ota, Tatsuya
Pallavicini, Alb ...
Panji, Sumir
Picone, Barbara
Ponting, Chris P ...
Prohaska, Sonja ...
Przybylski, Dari ...
Saha, Nil Ratan
Ravi, Vydianatha ...
Ribeiro, Filipe ...
Sauka-Spengler, ...
Scapigliati, Giu ...
Searle, Stephen ...
Sharpe, Ted
Simakov, Oleg
Stadler, Peter F ...
Stegeman, John J ...
Sumiyama, Kenta
Tabbaa, Diana
Tafer, Hakim
Turner-Maier, Ja ...
van Heusden, Pet ...
White, Simon
Williams, Louise
Yandell, Mark
Brinkmann, Henne ...
Volff, Jean-Nico ...
Tabin, Clifford ...
Shubin, Neil
Schartl, Manfred
Jaffe, David B.
Postlethwait, Jo ...
Venkatesh, Byrap ...
Di Palma, Federi ...
Lander, Eric S.
Meyer, Axel
Lindblad-Toh, Ke ...
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Nature
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Uppsala University

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