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Sökning: WFRF:(Larsen Stephan)

  • Resultat 1-10 av 34
  • [1]234Nästa
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  • Tidskriftsartikel (refereegranskat)
  • Müller, Christoph A., et al. (författare)
  • Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi-echo balanced steady-state free precession at 3 T
  • 2020
  • Ingår i: NMR in Biomedicine. - : John Wiley and Sons Inc.. - 0952-3480.
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL) reconstruction was implemented on a clinical 3 T positron-emission tomography/MRI system for fast 2D and 3D metabolic imaging. Simulations were conducted to obtain signal-efficient sequence protocols for the metabolic imaging of hyperpolarized biomolecules. The sequence was applied in vitro and in vivo for probing the enzymatic exchange of hyperpolarized [1–13C]pyruvate and [1–13C]lactate. Chemical shift resolution was achieved using a least-square, iterative chemical species separation algorithm in the reconstruction. In vitro, metabolic conversion rate measurements from me-bSSFP were compared with NMR spectroscopy and free induction decay-chemical shift imaging (FID-CSI). In vivo, a rat MAT-B-III tumor model was imaged with me-bSSFP and FID-CSI. 2D metabolite maps of [1–13C]pyruvate and [1–13C]lactate acquired with me-bSSFP showed the same spatial distributions as FID-CSI. The pyruvate-lactate conversion kinetics measured with me-bSSFP and NMR corresponded well. Dynamic 2D metabolite mapping with me-bSSFP enabled the acquisition of up to 420 time frames (scan time: 180-350 ms/frame) before the hyperpolarized [1–13C]pyruvate was relaxed below noise level. 3D metabolite mapping with a large field of view (180 × 180 × 48 mm3) and high spatial resolution (5.6 × 5.6 × 2 mm3) was conducted with me-bSSFP in a scan time of 8.2 seconds. It was concluded that Me-bSSFP improves the spatial and temporal resolution for metabolic imaging of hyperpolarized [1–13C]pyruvate and [1–13C]lactate compared with either of the FID-CSI or EPSI methods reported at 3 T, providing new possibilities for clinical and preclinical applications.
  • Tidskriftsartikel (refereegranskat)
  • Alkhazov, GD, et al. (författare)
  • SPES4-pi: installation for exclusive study of nuclear reactions
  • 2005
  • Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier. - 0167-5087. ; 551:2-3, s. 290-311
  • Tidskriftsartikel (refereegranskat)abstract
    • The paper describes the spectrometric system "SPES4-pi" used at the National Laboratory Saturne (CE Saclay, France) for the exclusive study of the baryon resonance excitation in inelastic alpha and d scattering on the proton, as well as coherent pion production in charge exchange reactions. The system consists of the magnetic spectrometer SPES4 and two wide-aperture position-sensitive detector arrays, equipped with wire chambers and scintillator hodoscopes, installed around a large-gap C-shape dipole magnet.
  • Bucchiarone, Antonio, et al. (författare)
  • From Monolithic to Microservices An Experience Report from the Banking Domain
  • 2018
  • Ingår i: IEEE Software. - : IEEE Computer Society. - 0740-7459 .- 1937-4194. ; 35:3, s. 50-55
  • Tidskriftsartikel (refereegranskat)abstract
    • Microservices have seen their popularity blossoming with an explosion of concrete applications in real-life software. Several companies are currently involved in a major refactoring of their back-end systems in order to improve scalability. This article presents an experience report of a real-world case study, from the banking domain, in order to demonstrate how scalability is positively affected by reimplementing a monolithic architecture into microservices. The case study is based on the FX Core system for converting from one currency to another. FX Core is a mission-critical system of Danske Bank, the largest bank in Denmark and one of the leading financial institutions in Northern Europe.
  • Bunea, Ada-Ioana, et al. (författare)
  • Micropatterned Carbon-on-Quartz Electrode Chips for Photocurrent Generation from Thylakoid Membranes
  • Ingår i: ACS Applied Energy Materials. - : The American Chemical Society (ACS). - 2574-0962. ; 1:7, s. 3313-3322
  • Tidskriftsartikel (refereegranskat)abstract
    • Harvesting the energy generated by photosynthetic organisms through light-dependent reactions is a significant step toward a sustainable future energy supply. Thylakoid membranes are the site of photosynthesis, and thus particularly suited for developing photo-bioelectrochemical cells. Novel electrode materials and geometries could potentially improve the efficiency of energy harvesting using thylakoid membranes. For commercial applications, electrodes with large surface areas are needed. Photolithographic patterning of a photoresist, followed by pyrolysis, is a flexible and fast approach for the fabrication of carbon electrodes with tailored properties. In this work, electrode chips consisting of patterned carbon supported on quartz were designed and fabricated. The patterned electrode area is 1 cm2, and the measurement chamber footprint is 0.5 cm2, 1 order of magnitude larger than previously tested electrodes for thylakoid membrane immobilization. The use of a transparent substrate allows back-side illumination, protecting the bioelectrochemical system from the environment and vice versa. Two different mediators, monomeric ([Ru(NH3)6]3+) and polymeric ([Os(2,2′-bipyridine)2-poly(N-vinylimidazole)10Cl]+/2+), are used for evaluating photocurrent generation from thylakoid membranes with different electrode geometries. Current densities up to 71 μA cm–2 are measured upon illumination through the transparent electrode chip with solar simulated irradiance (1000 W m–2).
  • Charles, Edquist, et al. (författare)
  • Cities and Regions in the New Learning Economy
  • 2001
  • Bok (övrigt vetenskapligt)abstract
    • The process of transforming the industrial economy into a society largely based on the production and dissemination of information and knowledge has widespread implications for cities and regions as well as organisations and individuals. And while the economy is increasingly global, the differences in economic development between cities and regions will not necessarily disappear. Indeed, the diversity in knowledge-based economic development reflects the complex interaction between global and local contexts as well as policies for increased decentralisation.Do regions and cities play new roles in terms of governance and intervention in order to promote innovation productivity and economic performance at the local level? What is the relationship between learning and social cohesion? A new OECD publication, Cities and Regions in the New Learning Economy, examines such questions by analysing e.g. the correlation between primary, secondary and tertiary education levels and GDP per capita in 180 regions of the European Union. While tertiary education remains important, secondary education appears as the most important for regional economic performance. The former is clearly essential in terms of innovations, but the latter represents the intermediary skills, which are also crucial to industrial know-how and "learning-by-doing". Moreover, the fact that university students and labour are mobile blurs the correlation between higher education and regional economic development.Although the experiences presented provide valuable insights, it should be stressed that high levels of individual learning in itself does not contribute to economic growth before it has been applied to the production of goods and services. The extent to which individuals and organisations absorb and apply learning and innovations will determine their competitiveness in the learning economy.The final chapter presents ten policy principles for regional and urban policy makers for helping their region or city to improve its economic performance in the new learning economy through the development of innovation-intensive activities.
  • Dragoni, Nicola, 1978-, et al. (författare)
  • Microservices : How To Make Your Application Scale
  • 2018
  • Ingår i: Perspectives of System Informatics. - : Springer. - 9783319743127 - 9783319743134 ; , s. 95-104
  • Konferensbidrag (refereegranskat)abstract
    • The microservice architecture is a style inspired by service-oriented computing that has recently started gaining popularity and that promises to change the way in which software is perceived, conceived and designed. In this paper, we describe the main features of microservices and highlight how these features improve scalability.
  • Larsen, Stephan (författare)
  • 2 x Ngugi
  • 2013
  • Ingår i: Karavan. - 1404-3874. ; :1, s. 73-74
  • Recension (populärvet., debatt m.m.)
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