| 1. |
- Nordanskog, Pia, et al.
(författare)
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Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression
- 2014
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Ingår i: Acta Psychiatrica Scandinavica. - United States : Wiley-Blackwell. - 0001-690X .- 1600-0447. ; 129:4, s. 303-311
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:In a previous magnetic resonance imaging (MRI) study, we found a significant increase in hippocampal volume immediately after electroconvulsive therapy (ECT) in patients with depression. The aim of this study was to evaluate hippocampal volume up to 1 year after ECT and investigate its possible relation to clinical and cognitive outcome.METHOD:Clinical and cognitive outcome in 12 in-patients with depression receiving antidepressive pharmacological treatment referred for ECT were investigated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a broad neuropsychological test battery within 1 week before and after ECT. The assessments were repeated 6 and 12 months after baseline in 10 and seven of these patients, respectively. Hippocampal volumes were measured on all four occasions with 3 Tesla MRI.RESULTS:Hippocampal volume returned to baseline during the follow-up period of 6 months. Neither the significant antidepressant effect nor the significant transient decrease in executive and verbal episodic memory tests after ECT could be related to changes in hippocampal volume. No persistent cognitive side effects were observed 1 year after ECT.CONCLUSION:The immediate increase in hippocampal volume after ECT is reversible and is not related to clinical or cognitive outcome.
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| 2. |
- Nordanskog, Pia, et al.
(författare)
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Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression : A Volumetric Magnetic Resonance Imaging Study
- 2010
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Ingår i: JOURNAL OF ECT. - 1095-0680 .- 1533-4112. ; 26:1, s. 62-67
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Tidskriftsartikel (refereegranskat)abstract
- Background: Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression.Methods: Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T magnetic resonance imaging within 1 week before and after the ECT series. Each hippocampus was manually outlined on coronal slices, and the volume was calculated.Results: The left as well as the right hippocampal volume increased significantly after ECT.Conclusions: The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression.
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| 3. |
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| 4. |
- Björkman, Anders, et al.
(författare)
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Cortical sensory and motor response in a patient whose hand has been replanted: One-year follow up with functional magnetic resonance imaging
- 2007
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Ingår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. - : Informa UK Limited. - 1651-2073 .- 0284-4311. ; 41:2, s. 70-76
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Tidskriftsartikel (refereegranskat)abstract
- Functional magnetic resonance imaging (fMRI) was used to study how a replanted hand regained its cortical territory parallel to recovery. The cortical response to sensory stimulation shifts from an ipsilateral to a bilateral pattern, and then to a predominantly contralateral activation. The cortical response to motor stimulation was normal from the first investigation.
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| 5. |
- Brockstedt, Sara, et al.
(författare)
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SchnelleMagnetresonanz-Bildgebung
- 2002
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Ingår i: Radiologie Up2Date. - : Georg Thieme Verlag KG. - 1616-0681 .- 1617-8300. ; :4, s. 413-438
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in German Die Verkürzung der Untersuchungszeiten bei der klinischen Magnetresonanztomographie (MRT) bietet für den Patienten den Vorteil einer angenehmeren und schnelleren Untersuchung und erhöht gleichzeitig den Patientendurchsatz. Dies erfordert schnelle und robuste Aufnahmetechniken, welche beispielsweise auch bei der Aufnahme bewegter Organe oder für atemangehaltene Messungen eingesetzt werden können. Durch die Entwicklung leistungsfähiger Gradientensysteme konnten in den letzten Jahren neue und schnelle Pulssequenzen entwickelt werden. Die rasante Entwicklung neuer Aufnahmemethoden und Rekonstruktionstechniken macht es für den Anwender immer wichtiger, die grundlegenden Prinzipien schneller Aufnahmetechniken zu verstehen. In diesem Übersichtsartikel wird versucht, die Grundlagen der schnellen Pulssequenzen und deren klinische Anwendungsbereiche darzustellen. Dies beinhaltet die schnelle Spin-Echo-Technik und deren Kombination mit selektiven Präparationstechniken, die schnelle und ultraschnelle Gradienten-Echo-Technik sowie die echoplanare Bildgebung. Abschließend werden kurz neueste Entwicklungen wie die parallele Bildgebung beschrieben.Zusammenfassung auf S. 434
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| 6. |
- Brockstedt, Sara, et al.
(författare)
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Vertical field MR imaging of upper thorax and spine in small children. Evaluation of a new surface coil
- 1993
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Ingår i: Acta Radiologica. - 1600-0455. ; 34:6, s. 549-553
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Tidskriftsartikel (refereegranskat)abstract
- To improve image quality in a vertical field MR imaging unit, operating at low field strength (0.3 T), we have designed a half-elliptical coil for use in the upper thoracic region of small children. Our intention was also to shorten the examination time, which until now has been long, because several scans with different coils have been necessary to cover the thoracic region. The experimental coil is designed so that a child's shoulders fit into the central region. The coil consists of 2 serially connected cable-loops, mounted on a foam rubber vest. The coil performance was tested in a phantom and improvements relative to standard coils were demonstrated in in vivo studies. The results indicate that by using the half-elliptical coil, the signal-to-noise (S/N) ratio can be improved by a factor of 2 to 3 in the thoracic region of a child.
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| 7. |
- Cronberg, Carin, et al.
(författare)
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Peripheral arterial disease.
- 2003
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Ingår i: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 44:1, s. 59-66
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Cronqvist, Mats, et al.
(författare)
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Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome.
- 2005
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Ingår i: Neuroradiology. - : Springer Science and Business Media LLC. - 1432-1920 .- 0028-3940. ; 47:11, s. 855-873
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Tidskriftsartikel (refereegranskat)abstract
- Our purpose was to evaluate treatment safety as well as complications frequency and management in endovascular coiling of intracerebral aneurysms using MR diffusion and perfusion imaging. In this prospective study, 77 MR examinations were performed in conjunction with 43 procedures in 40 patients, 14 patients presented with ruptured and 26 with unruptured aneurysms. Mean time interval between treatment and post-procedure MRI was 29 and 25 h for the ruptured and unruptured aneurysm group, respectively. Peri-procedural complications, including five major events and five minor transient events, occurred in 10/43 procedures (23%), necessitating thrombolytic therapy in two patients and angioplasty in one, all three within the unruptured aneurysm group. Fifty-one new lesions were found on post-treatment DWI and 47 of them were regarded as of ischemic origin. Most lesions were small (< 3 mm), ipsilateral to the treated aneurysm and asymptomatic (37/40 patients). Sixty-seven percent of the lesions were found in the ruptured and 33% in the unruptured aneurysm group. The ischemic lesions did occur more frequently in patients treated for aneurysm of large neck size and according to the remodelling technique. The overall morbidity and mortality rates were 14.6 and 7.3% whereas morbidity and mortality rates related to the technique were only 2.6 and 0%, respectively. Silent embolism seems to be more common than clinically evident and partially related to patient presentation, heparinazation and treatment strategy. The capability to depict early complications and analyse their potential causes by using MR with DWI has been of great importance in our modification and improvement of therapeutic protocols, evaluations and strategies.
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| 9. |
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| 10. |
- Elfgren, Christina, et al.
(författare)
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fMRI activity in the medial temporal lobe during famous face processing
- 2006
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Ingår i: NeuroImage. - : Elsevier BV. - 1095-9572 .- 1053-8119. ; 30:2, s. 609-616
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Tidskriftsartikel (refereegranskat)abstract
- The current event-related fMRI study examined the relative involvement of different parts of the medial temporal lobe (MTL), particularly the contribution of hippocampus and perirhinal cortex, in either intentional or incidental recognition of famous faces in contrast to unfamiliar faces. Our intention was to further explore the controversial contribution of MTL in the processing of semantic memory tasks. Subjects viewed a sequence of famous and unfamiliar faces. Two tasks were used encouraging attention to either fame or gender. In the fame task, the subjects were requested to identify the person when seeing his/her face and also to try to generate the name of this person. In the gender task, the subjects were asked to conduct a judgement of a person's gender when seeing his/her face. The visual processing was hence directed to gender and thereby expected to diminish attention to semantic information leading only to a “passive” registration of famous and non-familiar faces. Recognition of famous faces, in both contrasts, produced significant activations in the MTL. First, during the intentional recognition (the person identification task) increased activity was observed in the anterolateral part of left hippocampus, in proximity to amygdala. Second, during the incidental recognition of famous faces (the gender classification task), there was increased activity in the left posterior MTL with focus in the perirhinal cortex. Our results suggest that the hippocampus may be centrally involved in the intentional retrieval of semantic memories while the perirhinal cortex is associated with the incidental recognition of semantic information.
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