SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Larsson Helena) "

Sökning: WFRF:(Larsson Helena)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Delli, Ahmed, et al. (författare)
  • Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
  • 2012
  • Ingår i: Diabetes. - American Diabetes Association Inc.. - 1939-327X. ; 61:10, s. 2556-2564
  • Tidskriftsartikel (refereegranskat)abstract
    • We examined whether zinc transporter-8 autoantibodies (ZnT8A; arginine ZnT8-RA, tryptophan ZnT8-WA, and glutamine ZnT8-QA variants) differed between immigrant and Swedish patients due to different polymorphisms of SLC30A8, HLA-DQ, or both. Newly diagnosed autoimmune (≥1 islet autoantibody) T1D type 1 diabetic patients (n = 2,964, <18 years, 55% male) were ascertained in the Better Diabetes Diagnosis study. Two subgroups were identified: Swedes (n = 2,160, 73%) and immigrants (non-Swedes; n = 212, 7%). Non-Swedes had less frequent ZnT8-WA (38%) than Swedes (50%), consistent with a lower frequency in the non-Swedes (37%) of SLC30A8 CT+TT (RW+WW) genotypes than in the Swedes (54%). ZnT8-RA (57 and 58%, respectively) did not differ despite a higher frequency of CC (RR) genotypes in non-Swedes (63%) than Swedes (46%). We tested whether this inconsistency was due to HLA-DQ as 2/X (2/2; 2/y; y is anything but 2 or 8), which was a major genotype in non-Swedes (40%) compared with Swedes (14%). In the non-Swedes only, 2/X (2/2; 2/y) was negatively associated with ZnT8-WA and ZnT8-QA but not ZnT8-RA. Molecular simulation showed nonbinding of the relevant ZnT8-R peptide to DQ2, explaining in part a possible lack of tolerance to ZnT8-R. At diagnosis in non-Swedes, the presence of ZnT8-RA rather than ZnT8-WA was likely due to effects of HLA-DQ2 and the SLC30A8 CC(RR) genotypes.
3.
  • Jonsdottir, Berglind, et al. (författare)
  • Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis
  • 2017
  • Ingår i: The Journal of clinical endocrinology and metabolism. - Oxford University Press. - 1945-7197. ; 102:4, s. 1277-1285
  • Tidskriftsartikel (refereegranskat)abstract
    • CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up.SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register.RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription.CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age.
  •  
4.
  • Vaziri Sani, Fariba, et al. (författare)
  • A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.
  • 2011
  • Ingår i: Journal of Immunological Methods. - Elsevier. - 1872-7905. ; 371, s. 25-37
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA) for ZnT8A; 2) to identify the individual ZnT8-R,-W,-QA reactivity and 3) to validate the triple mix ZnT8A RBA in children with newly diagnosed T1D. METHODS: Serum samples were obtained from 2664 (56% males, n=1436) patients in the Swedish nationwide Better Diabetes Diagnosis (BDD) study representing patients with T1D (97%, n=2582), T2D (1.7%, n=46), MODY (1.0%, n=28) and secondary diabetes (0.3%, n=8). cDNA coding for the C-terminal end of each variant was prepared by site-directed mutagenesis and subcloned into a high efficiency in vitro transcription translation vector. The ZnT8 variants were labeled with 35S-methionine and used in a standard RBA separating free from autoantibody-bound autoantigen with Protein A-Sepharose. RESULTS: ZnT8-TripleA was detected in 1678 (65%) patients with T1D, 4 (9%) T2D, 3 (11%) MODY and in none (0%) of the patients with secondary diabetes. Among the T1D patients ZnT8-RA was detected in 1351 (52%) patients, ZnT8-WA in 1209 (47%) and ZnT8-QA in 790 (31%) demonstrating that 1661 (64%) had one or several ZnT8A. The ZnT8-TripleA assay showed a false positive rate of 1.9% (n=49). Only 1.2% (n=32) of the T1D patients were false negative for ZnT8-TripleA compared to 0/46 (0%) of the T2D patients. The precision (intra assay CV) and reproducibility (inter assay CV) of the ZnT8-TripleA assay did not differ from the RBA of the individual ZnT8 variants. CONCLUSION: We conclude that the ZnT8-TripleA assay had low false positive and false negative rates. The ZnT8-TripleA assay would therefore be highly suitable not only to analyze patient with newly diagnosed diabetes but also for screening the general population since this assay demonstrated high sensitivity and very high specificity.
  •  
5.
  • Larsson, Helena, et al. (författare)
  • Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up
  • 2011
  • Ingår i: Diabetes Care. - American Diabetes Association. - 1935-5548. ; 34:11, s. 2347-2352
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE-Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type I. diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries. RESEARCH DESIGN AND METHODS-Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register). RESULTS-A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register. CONCLUSIONS-Participation in the TEDDY study is associated with reduced risk of DMA at diagnosis of type 1 diabetes in young children.
  •  
6.
  • Ludvigsson, Johnny, et al. (författare)
  • GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
  • 2012
  • Ingår i: New England Journal of Medicine. - Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 366:5, s. 433-442
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong> The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.</p><p><strong>METHODS:</strong> We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.</p><p><strong>RESULTS:</strong> The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.</p><p><strong>CONCLUSIONS:</strong> Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period.</p>
  •  
7.
  •  
8.
  •  
9.
  • Andersson, Cecilia, et al. (författare)
  • Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study
  • 2013
  • Ingår i: Pediatric Diabetes. - 1399-543X .- 1399-5448. ; 14:5, s. 341-349
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>AIMS:</strong> Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children.</p><p><strong>METHODS:</strong> In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT.</p><p><strong>RESULTS:</strong> All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤ 30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤ 30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03).</p><p><strong>CONCLUSION:</strong> Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.</p>
  •  
10.
  • Andersson, Cecilia K, et al. (författare)
  • Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
  • 2013
  • Ingår i: Pediatric Diabetes. - Wiley-Blackwell. - 1399-543X. ; 14:5, s. 341-349
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS: In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT. RESULTS: All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03). CONCLUSION: Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (124)
Typ av publikation
tidskriftsartikel (336)
konferensbidrag (29)
annan publikation (23)
rapport (20)
bokkapitel (11)
doktorsavhandling (9)
visa fler...
samlingsverk (redaktörskap) (5)
forskningsöversikt (4)
bok (1)
patent (1)
licentiatavhandling (1)
recension (1)
visa färre...
Typ av innehåll
refereegranskat (352)
övrigt vetenskapligt (106)
populärvet., debatt m.m. (20)
Författare/redaktör
Larsson, Helena, (107)
Lernmark, Åke, (74)
Elding Larsson, Hele ... (49)
Carlsson, Annelie, (40)
Ludvigsson, Johnny, (29)
Ivarsson, Sten, (28)
visa fler...
Marcus, Claude (28)
Forsander, Gun, (25)
Larsson, Jenny Helen ... (25)
Larsson, Helena Eldi ... (23)
Samuelsson, Ulf, (21)
Törn, Carina, (20)
Larsson, Christer, (18)
Lernmark, Ake, (18)
Lundgren, Markus, (17)
LERNMARK, A (16)
Ramelius, Anita, (16)
Vaziri Sani, Fariba, (16)
Mathiassen, Svend Er ... (15)
Kockum, Ingrid, (15)
Akolkar, Beena, (15)
Hallman, David, 1979 ... (15)
Bjärntoft, Sofie, (15)
Jahncke, Helena, 198 ... (15)
Larsson, Karin, (14)
Jernberg-Wiklund, He ... (14)
Larsson, Johan, 1979 ... (14)
Lindblad, Bengt (13)
Kjellberg, Anders, (13)
Jonsdottir, Berglind ... (13)
She, Jin-Xiong (13)
Ziegler, Anette-G (13)
Zetterberg, Camilla, ... (13)
Edvinsson, Johanna, (13)
Cilio, Corrado, (12)
Ludvigsson, J (12)
Vehik, Kendra, (12)
Bergsten, Eva, 1969- ... (12)
Larsson, Anders, (11)
Lynch, Kristian, (11)
Marcus, C, (11)
Forsander, G (11)
Toppari, Jorma (11)
Hagopian, William A. ... (11)
Krischer, Jeffrey P. ... (11)
Tegern, Matthias (11)
Larsson, Elna-Marie, (10)
Ivarsson, Sten A (10)
Delli, Ahmed, (10)
Hansson, Gertie, (10)
visa färre...
Lärosäte
Lunds universitet (152)
Uppsala universitet (74)
Göteborgs universitet (50)
Stockholms universitet (40)
Linköpings universitet (30)
Karolinska Institutet (23)
visa fler...
Umeå universitet (18)
Högskolan i Gävle (18)
Kungliga Tekniska Högskolan (10)
Sveriges Lantbruksuniversitet (9)
Högskolan Kristianstad (8)
Örebro universitet (8)
Högskolan Dalarna (7)
Luleå tekniska universitet (6)
swepub_uni:mau_t (6)
Chalmers tekniska högskola (6)
RISE (4)
Naturvårdsverket (2)
Mittuniversitetet (2)
Karlstads universitet (2)
Högskolan Väst (1)
Högskolan i Jönköping (1)
Högskolan i Skövde (1)
Gymnastik- och idrottshögskolan (1)
Blekinge Tekniska Högskola (1)
VTI - Statens väg- och transportforskningsinstitut (1)
Sophiahemmet Högskola (1)
visa färre...
Språk
Engelska (361)
Svenska (52)
Danska (6)
Odefinierat språk (3)
Franska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (308)
Teknik (33)
Naturvetenskap (31)
Humaniora (30)
Samhällsvetenskap (26)
Lantbruksvetenskap (14)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy