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- Alexius, Susanna, 1976-, et al.
(författare)
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Market Means to Political Mission Ends : Scrutinizing the Social Meaning of Moneyin the Swedish Federation for Sexual Education (RFSU)
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In the nonprofit debate, there is an assumption that market means lead to market ends, oftentimes with grim consequences for nonprofit organizations. By drawing on a theoretical framework related to the social meaning of money in hybrid organizations, and by applying the framework to a longitudinal mixedmethod single case study ofmoneymanagement in the Swedish Federation for Sexual Education (RFSU), we argue in this paper instead that management of market means may also promote political mission ends. Empirical findings suggest that there are different social currencies at play that help explain why some money (income of a lower perceived social status) may be used by the organization simply as a means to get access to higher status money (and the legitimacy that comes with it). Hence, contrary to common assumptions of mission-drift as a consequence of market means, in this case study, business dividends and royalties commercially generated in fully owned subsidiaries have been informally and formally earmarked as lower status money and then used as means to secure higher status political mission ends.
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- Alexius, Susanna, et al.
(författare)
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Vad har ni för värden på kontot?
- 2017
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Ingår i: Kurage. - 2001-175X.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Kan en organisations olika intäkter användas till samma saker? Eller är det skillnad på en medlemsavgift och ett testamente? Eller ett offentligt bidrag? Ledare i organisationer verkar värdera olika intäkter på olika sätt och frågan är om en krona alltid är en krona. Forskarna Susanna Alexius och Ola Segnestam Larsson funderar på om pengar har olika värden.
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- de Jong, Jasper M. A., et al.
(författare)
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A stringent validation of mouse adipose tissue identity markers
- 2015
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Ingår i: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 308:12, s. E1085-E1105
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Tidskriftsartikel (refereegranskat)abstract
- The nature of brown adipose tissue in humans is presently debated: whether it is classical brown or of brite/beige nature. The dissimilar developmental origins and proposed distinct functions of the brown and brite/beige tissues make it essential to ascertain the identity of human depots with the perspective of recruiting and activating them for the treatment of obesity and type 2 diabetes. For identification of the tissues, a number of marker genes have been proposed, but the validity of the markers has not been well documented. We used established brown (interscapular), brite (inguinal), and white (epididymal) mouse adipose tissues and corresponding primary cell cultures as validators and examined the informative value of a series of suggested markers earlier used in the discussion considering the nature of human brown adipose tissue. Most of these markers unexpectedly turned out to be noninformative concerning tissue classification (Car4, Cited1, Ebf3, Eva1, Fbxo31, Fgf21, Lhx8, Hoxc8, and Hoxc9). Only Zic1 (brown), Cd137, Epsti1, Tbx1, Tmem26 (brite), and Tcf21 (white) proved to be informative in these three tissues. However, the expression of the brite markers was not maintained in cell culture. In a more extensive set of adipose depots, these validated markers provide new information about depot identity. Principal component analysis supported our single-gene conclusions. Furthermore, Zic1, Hoxc8, Hoxc9, and Tcf21 displayed anteroposterior expression patterns, indicating a relationship between anatomic localization and adipose tissue identity (and possibly function). Together, the observed expression patterns of these validated marker genes necessitates reconsideration of adipose depot identity in mice and humans.
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- Gunnarsdottir, Frida Björk, et al.
(författare)
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Serum immuno-oncology markers carry independent prognostic information in patients with newly diagnosed metastatic breast cancer, from a prospective observational study
- 2023
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Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 25
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Tidskriftsartikel (refereegranskat)abstract
- Background Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of survival.Patients and methods We investigated a broad panel of 92 immuno-oncology proteins in serum from 136 MBC patients included in a prospective observational study (NCT01322893) with long-term follow-up. Serum samples were collected before start of systemic therapy and analyzed using multiplex proximity extension assay (Olink Target 96 Immuno-Oncology panel). Multiple machine learning techniques were used to identify serum markers with highest importance for prediction of overall and progression-free survival (OS and PFS), and associations to survival were further evaluated using Cox regression analyses. False discovery rate was then used to adjust for multiple comparisons.Results Using random forest and random survival forest analyses, we identified the top nine and ten variables of highest predictive importance for OS and PFS, respectively. Cox regression analyses revealed significant associations (P < 0.005) of higher serum levels of IL-8, IL-10 and CAIX with worse OS in multivariable analyses, adjusted for established clinical prognostic factors including circulating tumor cells (CTCs). Similarly, high serum levels of IL-8, IL-10, ADA and CASP8 significantly associated with worse PFS. Interestingly, high serum levels of FasL significantly associated with improved OS and PFS. In addition, CSF-1, IL-6, MUC16, TFNSFR4 and CD244 showed suggestive evidence (P < 0.05) for an association to survival in multivariable analyses. After correction for multiple comparisons, IL-8 still showed strong evidence for correlation to survival.Conclusion To conclude, we found six serum immuno-oncology markers that were significantly associated with OS and/or PFS in MBC patients, independently of other established prognostic factors including CTCs. Furthermore, an additional five serum immuno-oncology markers provided suggestive evidence for an independent association to survival. These findings highlight the relevance of immuno-oncology serum markers in MBC patients and support their usefulness for improved prognostication.
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| 8. |
- Jutterström, Mats, et al.
(författare)
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Anställd i det svenska civilsamhället - engagemang, ansvar och delaktighet
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tack vare tidigare forskning vet vi förhållandevis mycket om hur det är att vara medlem eller frivillig i ideella organisationer i Sverige. Men hur är det att vara anställd i det svenska civilsamhället? Med denna studie vill vi bidra till kunskapen om anställdas arbetsvillkor och drivkrafter i ideella organisationer i Sverige. Områden av intresse inkluderar till exempel vad som kännetecknar organisationer med anställda i det svenska civilsamhället, vilka de anställda är och vad de har för befattningar och villkor samt hur de anställda ser på för- och nackdelar med att arbeta i ideell sektor i jämförelse med privat och offentlig sektor.
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- Karlsson, Patrik, 1977-, et al.
(författare)
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Enhetschefers syn på kunskapsformers och ramfaktorers betydelse för insatser inom socialtjänsten
- 2021
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Ingår i: Socialvetenskaplig tidskrift. - 1104-1420 .- 2003-5624. ; 28:2, s. 209-230
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Tidskriftsartikel (refereegranskat)abstract
- Det är väl belagt i internationell forskning att en pluralism av olika kunskapsformer och organisatoriska förhållanden påverkar val och utformning av insatser inom socialt arbete. I den svenska kontexten har det visat sig att dessa kunskapsformer och så kallade ramfaktorer kan framstå som svårförenliga eller till och med i konflikt med varandra. Samtidigt saknas det aktuella svenska studier som på en nationell nivå visar vilken utbredning och upplevd betydelse kunskapsformer och ramfaktorer har för kommunernas utbud och val av insatser. I artikeln presenterar vi en nationell studie av enhetschefers syn på olika kunskapsformers och ramfaktorers förekomst och betydelse för utbud och beslut om insatser inom socialtjänstens individ- och familjeomsorg. Artikeln bygger på data från en nationell enkät riktad till enhetschefer för ett urval av Sveriges kommuners barn- och familje- respektive missbruksverksamheter. Resultaten visar att samtliga undersökta kunskapsformer och ramfaktorer påverkar val och utformning av insats, men att vissa former mer framträdande än andra. Främst baseras val och utformning av insats på individuell erfarenhetsbaserad kunskap från yrkeserfarenhet och utbildning, snarare än kollektiv professionell kunskap. Vidare menar enhetscheferna att systematiska kunskapssammanställningar påverkar i högre utsträckning än enskilda kvalitativa och kvantitativa forskningsstudier inom vetenskaplig kunskap. När det gäller ramfaktorer visar studien att insatsens kostnad påverkar i mindre utsträckning än faktorer som tillgänglighet, ramavtal och lagstiftning.
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| 10. |
- Larsson, Aron, et al.
(författare)
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Implementing Second-Order Decision Analysis : Concepts, Algorithms, and Tool
- 2014
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Ingår i: Advances in Decision Sciences. - : Asia University. - 2090-3359 .- 2090-3367.
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Tidskriftsartikel (refereegranskat)abstract
- We present implemented concepts and algorithms for a simulation approach to decision evaluation with second-order belief distributions in a common framework for interval decision analysis. The rationale behind this work is that decision analysis with interval-valued probabilities and utilities may lead to overlapping expected utility intervals yielding difficulties in discriminating between alternatives. By allowing for second-order belief distributions over interval-valued utility and probability statements these difficulties may not only be remedied but will also allow for decision evaluation concepts and techniques providing additional insight into a decision problem. The approach is based upon sets of linear constraints together with generation of random probability distributions and utility values from implicitly stated uniform second-order belief distributions over the polytopes given from the constraints. The result is an interactive method for decision evaluation with second-order belief distributions, complementing earlier methods for decision evaluation with interval-valued probabilities and utilities. The method has been implemented for trial use in a user oriented decision analysis software.
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